Article
Cell Biology
Kia Wee Tan, Viola Nahse, Coen Campsteijn, Andreas Brech, Kay Oliver Schink, Harald Stenmark
Summary: The study identifies JIP4 and Phafin2 as crucial components in the recycling pathway from macropinosomes, with their interaction and impact on PtdIns3P affecting the retention and processing of internalized cargoes in cells.
JOURNAL OF CELL SCIENCE
(2021)
Article
Microbiology
Wei Pan, Nie Hui, Hongmei Wang, Hongbin He
Summary: Bovine parainfluenza virus 3 enters MDBK cells via macropinocytosis and clathrin-mediated endocytosis, requiring acid-dependent entry and cathepsin L. Additionally, macropinocytosis is dependent on actin dynamics during BPIV3 infection.
VETERINARY MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hui Tu, Zhimeng Wang, Ye Yuan, Xilin Miao, Dong Li, Hu Guo, Yihong Yang, Huaqing Cai
Summary: The study identifies a complex composed of two proteins, PripA and TbcrA, that plays a central role in the conversion of Rab5 to Rab7 during macropinosome maturation, facilitating efficient cargo trafficking.
NATURE COMMUNICATIONS
(2022)
Article
Agriculture, Dairy & Animal Science
Tamas Mato, Andras Medveczki, Istvan Kiss
Summary: This article reports on the molecular typing of IBDVs in Central Europe in recent years, revealing the diversity of IBDV in the region and emphasizing the importance of regular monitoring of flocks and adjusting control measures accordingly.
Article
Microbiology
Qiuxia Wang, Fuming Chu, Xin Zhang, Huilong Hu, Lang Lu, Fang Wang, Yan Yu, Yanhong Zhang, Jinyou Ma, Zhiyong Xu, Fatma Eldemery, Changbo Ou, Xingyou Liu
Summary: This study investigated the impact of CCL19 on IBDV replication. The results showed that CCL19 could decrease the gene and protein levels of IBDV, and overexpression of CCL19 led to a significant reduction in IBDV content. This suggests that CCL19 may play a crucial role in the pathogenesis of IBDV.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Maria Cecilia Gimenez, Mariam Issa, Javal Sheth, Maria Isabel Colombo, Mauricio R. Terebiznik, Laura R. Delgui
Summary: This study reveals that Infectious bursal disease virus (IBDV) utilizes endosomal membranes for replication, with the association depending on the viral protein VP3 and host cell phosphatidylinositide lipids [PtdIns(3)P]. The role of PtdIns(3)P in IBDV replication is crucial, indicating a novel mechanism in the replication of a dsRNA virus.
JOURNAL OF VIROLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Deping Han, Yurong Tai, Guoying Hua, Xue Yang, Jianfei Chen, Junying Li, Xuemei Deng
Summary: Melanocytes in black-boned chickens are widely distributed in their inner organs and play important innate immune roles during virus infection. Genes related to the TLR signaling pathway were highly detected during infectious bursal disease virus infection, indicating the involvement of melanocytes in the immune response against the virus.
Article
Cell Biology
Hugo Moreiras, Liliana Bento-Lopes, Matilde V. Neto, Cristina Escrevente, Luis C. Cabaco, Michael J. Hall, Jose S. Ramalho, Miguel C. Seabra, Duarte C. Barral
Summary: Different internalization pathways are followed by keratinocytes for the uptake of melanocores and melanosomes. Melanocores are internalized via phagocytosis, while melanosomes are internalized via macropinocytosis. Furthermore, the uptake of melanocores induces a higher level of protease-activated receptor-2 (PAR-2) internalization by keratinocytes compared to melanosomes, supporting the melanocore-based mechanism of melanin transfer.
Review
Virology
Wenying Zhang, Xiaomei Wang, Yulong Gao, Xiaole Qi
Summary: This report briefly discusses and summarizes the epidemic history of infectious bursal disease virus (IBDV) in China, which is of great significance for scientific cognition and the comprehensive prevention and control of the disease.
Article
Multidisciplinary Sciences
Xiang Zhao, Su Guo
Summary: Asymmetric cell division is fundamental for generating cellular diversity. Using zebrafish embryos, the dynamic endocytosis of Notch ligand DeltaD has been shown to play a crucial role in cell fate determination during asymmetric cell division.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Immunology
Yossi Wein, Virginie Loeb, Aderajew Asmare, Saar Tal, Avner Finger, Aharon Friedman
Summary: MB-1 is a attenuated infectious bursal disease virus vaccine. It was observed that the vaccine virus replicated with a temporal delay due to maternally derived antibodies (MDAs). The mechanism of its survival despite MDA neutralization remained unclear. After vaccination at 1 day of age, MB-1 virus penetrates and resides in local macrophages, which are then distributed to lymphoid organs. The ability of MB-1 to survive within macrophages ensures its survival during effective MDA protection.
Article
Virology
Anna Pikula, Anna Lisowska, Katarzyna Domanska-Blicharz
Summary: Infectious bursal disease virus (IBDV) is a widespread immunosuppressive pathogen that causes significant losses in poultry production. It undergoes genetic changes through mutations and reassortment, leading to the emergence of new variants and changing the epidemiological situation. A recent study in northwestern Europe reported a large wave of IBDV A3B1 reassortant infections. In Poland, the largest producer of chicken meat in the EU, IBDV genotypes A3B2 and A3B4 were circulating before the emergence of A3B1 reassortants.
Article
Veterinary Sciences
Towseef Akram, Irfan Gul, Mahrukh Parveez Zia, Amreena Hassan, Amina Khatun, Riaz Ahmad Shah, Syed Mudasir Ahmad, Nazir Ahmad Ganai, Naveed Anjum Chikan, Won-Il Kim, Nadeem Shabir
Summary: This study explores the effect of different antivirals on the replication of a specific virus and investigates the mechanisms behind the most effective anti-viral drug. The results show that ribavirin has the least cytotoxicity and significantly inhibits the replication of the virus. Ribavirin primarily inhibits the virus through IMPDH-mediated depletion of the Guanosine Triphosphate pool of cells, rather than through mutagenesis.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Immunology
Yulong Wang, Nan Jiang, Linjin Fan, Li Gao, Kai Li, Yulong Gao, Xinxin Niu, Wenying Zhang, Hongyu Cui, Aijing Liu, Qing Pan, Changjun Liu, Yanping Zhang, Xiaomei Wang, Xiaole Qi
Summary: The study successfully expressed the VP2 protein of nVarIBDV strain SHG19 and developed a VLP vaccine based on this protein, which provided 100% protection against nVarIBDV and good protection against vvIBDV. This research has significant implications for the comprehensive prevention and control of the recent atypical IBD epidemic.
Article
Multidisciplinary Sciences
Lucia Maria Ghietto, Pedro Ignacio Gil, Paloma Olmos Quinteros, Emiliano Gomez, Franco Martin Piris, Patricia Kunda, Marta Contigiani, Maria Gabriela Paglini
Summary: This study investigates the early events of the replication cycle of Pixuna virus and Rio Negro virus, two mosquito-borne alphaviruses. The findings show that these viruses are primarily internalized through clathrin-mediated endocytosis and the low pH in endosomes is crucial for viral replication. Understanding the entry route of these viruses is important for understanding their pathogenesis and developing new antiviral strategies.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Laura R. Delgui, Maria I. Colombo
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Virology
Liliana L. Cubas-Gaona, Elisabet Diaz-Beneitez, Marina Ciscar, Jose F. Rodriguez, Dolores Rodriguez
JOURNAL OF VIROLOGY
(2018)
Article
Virology
Maria Cecilia Gimenez, Flavia Adriana Zanetti, Mauricio R. Terebiznik, Maria Isabel Colombo, Laura Ruth Delgui
JOURNAL OF VIROLOGY
(2018)
Review
Cell Biology
Milton O. Aguilera, Laura R. Delgui, Patricia S. Romano, Maria I. Colombo
Article
Virology
Julieta S. Roldan, Wilda A. Candurra, Marla Colombo, Laura R. Delgui
JOURNAL OF VIROLOGY
(2019)
Article
Infectious Diseases
M. J. Tohme, M. C. Gimenez, A. Peralta, M. I. Colombo, L. R. Delgui
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2019)
Article
Multidisciplinary Sciences
Ginesa Avila-Perez, Elisabet Diaz-Beneitez, Liliana L. Cubas-Gaona, Gliselle Nieves-Molina, Juan Ramon Rodriguez, Jose F. Rodriguez, Dolores Rodriguez
Article
Immunology
Ana C. Lopez Giuliani, Eva Hernandez, Maria J. Tohme, Clemence Taisne, Julieta S. Roldan, Clara Garcia Samartino, Marion Lussignol, Patrice Codogno, Maria I. Colombo, Audrey Esclatine, Laura R. Delgui
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Virology
Maria Cecilia Gimenez, Mariam Issa, Javal Sheth, Maria Isabel Colombo, Mauricio R. Terebiznik, Laura R. Delgui
Summary: This study reveals that Infectious bursal disease virus (IBDV) utilizes endosomal membranes for replication, with the association depending on the viral protein VP3 and host cell phosphatidylinositide lipids [PtdIns(3)P]. The role of PtdIns(3)P in IBDV replication is crucial, indicating a novel mechanism in the replication of a dsRNA virus.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Diego S. Ferrero, Idoia Busnadiego, Damia Garriga, Pablo Guerra, Maria Teresa Martin, Leonor Kremer, Isabel Uson, Jose Francisco Rodriguez, Nuria Verdaguer
Summary: VP3 is a multifunctional protein in birnaviruses, essential for coordinating the virus life cycle and interacting with various viral components. The N-terminal domain of VP3 in drosophila X virus is responsible for binding to dsRNA and suppressing host gene silencing responses. This study provides structural and functional insights into the crucial roles of VP3 in birnaviruses.
JOURNAL OF VIROLOGY
(2021)
Review
Microbiology
Maria Julieta Tohme, Laura Ruth Delgui
Summary: Group A rotaviruses are the main cause of severe acute gastroenteritis in children under 5 years of age, leading to nearly 130,000 deaths worldwide each year. Social conditions in developing countries contribute to decreased oral rehydration and vaccine efficacy, along with the lack of approved antiviral drugs, making RVA a global health concern. Research focuses on viral virion structure and replication cycle, aiming to explore potential treatments for RVA-associated AGE, particularly novel broad-spectrum therapeutic options.
Review
Cell Biology
Claudio M. Fader Kaiser, Patricia S. Romano, M. Cristina Vanrell, Cristian A. Pocognoni, Julieta Jacob, Benjamin Caruso, Laura R. Delgui
Summary: Lipid droplets (LD) are not just fat drops, but they are ubiquitous in diverse organelles and have various functions. LD biogenesis starts in the endoplasmic reticulum, and their main function is to buffer energy and participate in lipid metabolism, protein homeostasis, stress protection, tumor proliferation, pathogen replication, and defense. LD play a crucial role in many diseases caused by intracellular pathogens and cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Virology
Yesica R. Frontini-Lopez, Lautaro Rivera, Cristian A. Pocognoni, Julieta S. Roldan, Maria I. Colombo, Marina Uhart, Laura R. Delgui
Summary: Gumboro illness is caused by the highly contagious immunosuppressive infectious bursal disease virus (IBDV), which affects the poultry industry globally. Previous research has shown that IBDV utilizes the endocytic pathway and crucial proteins involved in the secretory pathway for viral replication. This study further elucidates the assembly sites of IBDV and demonstrates the impact of IBDV infection on the stress response of the endoplasmic reticulum.
Article
Virology
Maria C. Gimenez, Yesica R. Frontini-Lopez, Cristian A. Pocognoni, Julieta S. Roldan, Clara Garcia Samartino, Marina Uhart, Maria Colombo, Mauricio R. Terebiznik, Laura R. Delgui
Summary: This article investigates the replication mechanism of infectious bursal disease virus (IBDV) in host cells. The study found that IBDV establishes replication complexes on endosomes associated with the Golgi complex by hijacking the endocytic pathway. Additionally, the study discovered that the Rab1b-GBF1-ARF1 axis plays a crucial role in IBDV replication. These findings contribute significantly to the understanding of birnavirus-host cell interactions and the proposed evolutionary connection role of birnaviruses.
JOURNAL OF VIROLOGY
(2022)
Article
Cell Biology
Aldana D. Gojanovich, Maria C. Gimenez, Diego Masone, Tania M. Rodriguez, Ricardo A. Dewey, Laura R. Delgui, Diego M. Bustos, Marina Uhart
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2018)