Review
Pharmacology & Pharmacy
Lan Lu, Mingxing Li, Guojuan Yi, Li Liao, Qiang Cheng, Jie Zhu, Bin Zhang, Yingying Wang, Yong Chen, Ming Zeng
Summary: Interference with quorum sensing is an important strategy for the treatment of bacterial infections and restoring antibiotic tolerance. The discovery of quorum sensing inhibitors has a significant impact on the development of anti-infective drugs. Various approaches exist for the discovery of quorum sensing inhibitors.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Review
Pharmacology & Pharmacy
Eve W. L. Chow, Li Mei Pang, Yue Wang
Summary: Many human fungal pathogens are opportunistic, becoming infectious when the host's immunity and microbiome are compromised. Bacteria in the human microbiome play a crucial role in keeping fungi harmless and defending against fungal infection. The Human Microbiome Project has significantly advanced our understanding of the interaction between bacteria and fungi, providing insights for developing antifungal strategies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Gastroenterology & Hepatology
Ying Su, Tao Ding
Summary: Bacteria use a mechanism called quorum sensing (QS) to synchronize social behaviors through cell-cell communication and interaction. Although the role of QS in pathogens during laboratory engineered infections has been proven, the potential functions of QS related to pathogenesis in microbial consortia are still poorly understood. This review summarizes the basic molecular mechanisms of QS, specifically focusing on pathogenic microbes driving gastrointestinal (GI) infections. It discusses how GI pathogens disturb the homeostasis of the indigenous microbial consortia, dominate the realm, and interact with the host under worsening infectious conditions through pathogen-biased QS signaling. Additionally, it presents recent applications and main challenges of manipulating the QS network in microbial consortia for a better understanding of GI bacterial sociality and the development of novel therapies targeting bacterial infections.
Review
Pharmacology & Pharmacy
Emilli Karine Marcomini, Melyssa Negri
Summary: New strategies to control fungal biofilms, especially through interfering in quorum sensing, are crucial. However, little is known about the effect of antiseptics and quorum-sensing molecules (QSMs) due to limited studies on specific fungal genera. In this review, we analyze 13 fungal QSMs in silico and highlight 4-hydroxyphenylacetic acid and tryptophol as promising antifungal agents. We also recommend further in vitro studies on the association of QSMs with commonly used antiseptics as potential antibiofilm agents.
DRUG DISCOVERY TODAY
(2023)
Article
Microbiology
Zhengyuan Zhou, Ruiwen Hu, Yanmei Ni, Wei Zhuang, Zhiwen Luo, Weiming Huang, Qingyun Yan, Zhili He, Qiuping Zhong, Cheng Wang
Summary: The study revealed that the endosphere of mangrove roots is a distinctive compartment with denser co-occurrences in the bacterial-fungal network compared to peripheral compartments. Additionally, specific key bacterial taxa in the endosphere were found to intensify inter-domain associations with fungi and stimulate biofilm formation. Genetic evidence supports the critical role of the soil-root interface in structuring the microbial inter-domain associations.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Wouter A. G. Beenker, Jelmer Hoeksma, Jeroen den Hertog
Summary: Quorum sensing is an important bacterial regulatory mechanism, and inhibiting quorum sensing is a promising strategy against bacterial infections. This study discovered various fungal-produced quorum sensing inhibitors and identified gregatins as a family of compounds with quorum sensing inhibitor activity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Ecology
Adela M. Lujan, Steve Paterson, Elze Hesse, Lea M. Sommer, Rasmus L. Marvig, M. D. Sharma, Ellinor O. Alseth, Oana Ciofu, Andrea M. Smania, Soren Molin, Helle Krogh Johansen, Angus Buckling
Summary: Co-infecting pathogens can influence the selection of Pseudomonas aeruginosa mutators, limiting their fixation. This study is important for understanding bacterial evolution in chronic infections.
NATURE ECOLOGY & EVOLUTION
(2022)
Review
Microbiology
Linbo Li, Yuru Pan, Shishuang Zhang, Tianyou Yang, Zhigang Li, Baoshi Wang, Haiyan Sun, Mingxia Zhang, Xu Li
Summary: This review summarizes the research history and hotspots of quorum sensing (QS) in Saccharomyces cerevisiae, focusing on the regulatory mechanism of quorum sensing molecule (QSM) synthesis, factors influencing QSM production, and the response mechanism of QSMs. The review also highlights the applications of QS in stress adaptation, increasing fermentation products, and food preservation in S. cerevisiae.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Microbiology
Kayla A. Simanek, Jon E. Paczkowski
Summary: Bacteria use a process called quorum sensing to coordinate collective behaviors. This process relies on the detection of extracellular signal molecules known as autoinducers. In the human pathogen Pseudomonas aeruginosa, quorum sensing is important for virulence and biofilm formation. However, the signaling hierarchy and regulatory mechanisms of the receptors involved in this process are still not well understood, leading to chronic infection.
Review
Polymer Science
Moupriya Nag, Dibyajit Lahiri, Dipro Mukherjee, Ritwik Banerjee, Sayantani Garai, Tanmay Sarkar, Sujay Ghosh, Ankita Dey, Sougata Ghosh, Smaranika Pattnaik, Hisham Atan Edinur, Zulhisyam Abdul Kari, Siddhartha Pati, Rina Rani Ray
Summary: Chitosan and its nano materials show potential in combating drug resistance by disrupting quorum sensing in microbial biofilms, offering a solution for treating chronic infections and preparing medical devices. Through interaction with amino groups on microorganisms, they disrupt membrane permeability and induce cell death.
Review
Pharmacology & Pharmacy
Alessandro Polizzi, Martina Donzella, Giada Nicolosi, Simona Santonocito, Paolo Pesce, Gaetano Isola
Summary: Chemical molecules are used by microorganisms for communication through quorum sensing. Inhibiting quorum sensing can disrupt oral biofilm formation and reduce the impact of periodontitis. The use of antibiotics and antiseptics carries risks, while quorum sensing inhibitors have potential as a solution for treating periodontitis.
Review
Microbiology
Xiaojie Zhang, Baobao Liu, Xueyan Ding, Peng Bin, Yang Yang, Guoqiang Zhu
Summary: The QS system plays a central role in the regulation of virulence in Salmonella, and blocking this system may be a new strategy for treating Salmonella infection. Studying the application of QQ technology in Salmonella infection can provide insight into the regulation mechanism of bacterial virulence.
Review
Biochemistry & Molecular Biology
Giovanna Batoni, Giuseppantonio Maisetta, Semih Esin
Summary: Many chronic infections have a polymicrobial etiology, posing challenges in treatment. Microbial communities form biofilms that are resistant to therapy, while interactions affect pathogen susceptibility. AMPs show therapeutic potential in mixed infections but may have limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Phillipp Hartmann, Bernd Schnabl
Summary: Liver and biliary diseases have a significant impact on global health, with the intestinal bacterial microbiome playing a well-established role. However, the role of the fungal microbiome, or mycobiome, has been overlooked for a long time. Recent studies have highlighted the importance of the mycobiome in hepatobiliary diseases, particularly the involvement of the Candida genus. This article compares colonization and infection, describes mycobiome findings in healthy and diseased states, and discusses the potential for modulating the gut mycobiome to improve hepatobiliary conditions.
JOURNAL OF HEPATOLOGY
(2023)
Review
Microbiology
Evgeniya V. Prazdnova, Andrey V. Gorovtsov, Nikita G. Vasilchenko, Maxim P. Kulikov, Varvara N. Statsenko, Anna A. Bogdanova, Alexandr G. Refeld, Yaroslav A. Brislavskiy, Vladimir A. Chistyakov, Michael L. Chikindas
Summary: This review focuses on the mechanisms of quorum-sensing suppression by Gram-positive microorganisms and its practical applications in food fermentation, probiotics, and biotechnology. It also discusses the possible evolutionary role of quorum-quenching mechanisms during the development of interspecies interactions of bacteria.
Article
Cell Biology
Leanne M. Smith, Emily F. Dixon, Robin C. May
CELLULAR MICROBIOLOGY
(2015)
Article
Obstetrics & Gynecology
Victoria Hodgetts-Morton, Catherine A. Hewitt, Arnie Wilson, Nicola Farmer, Annalise Weckesser, Emily Dixon, Peter Brocklehurst, Pollyanna Hardy, Rachel K. Morris
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2020)
Article
Medicine, General & Internal
Jane P. Daniels, Emily Dixon, Alicia Gill, Jon Bishop, Mark Wilks, Michael Millar, Jim Gray, Tracy E. Roberts, Jane Plumb, Jonathan J. Deeks, Karla Hemming, Khalid S. Khan, Shakila Thangaratinam
Summary: This study evaluated the use of intrapartum rapid test to detect maternal GBS colonization in women with clinical risk factors for early neonatal infection. The results showed that the use of rapid test did not reduce the rates of antibiotics administered to prevent neonatal early-onset GBS infection compared to usual care. The accuracy of the rapid test is within acceptable limits.
Article
Health Care Sciences & Services
Jane Daniels, Emily F. Dixon, Alicia Gill, Jon Bishop, Maria D'Amico, Khaled Ahmed, Julie Dodds, Kostas Tryposkiadis, Mark Wilks, Michael Millar, Shahid Husain, Jim Gray, Angela Whiley, Patrick Moore, Ruvimbo L. Munetsi, Karla Hemming, Tracy Roberts, Jane Plumb, Jonathan Deeks, Khalid S. Khan, Shakila Thangaratinam
Summary: This study investigated whether intrapartum antibiotic prophylaxis guided by a rapid test reduces antibiotic use in mothers and neonates. The results showed that this strategy did not reduce the rates of antibiotic prophylaxis for preventing early-onset group B Streptococcus infection, but did reduce neonatal antibiotic exposure.
HEALTH TECHNOLOGY ASSESSMENT
(2022)
Article
Medicine, Research & Experimental
Vibhu Paudyal, Richard Lowrie, Frances S. S. Mair, Lee Middleton, Versha Cheed, Jennifer Hislop, Andrea Williamson, Nigel Barnes, Catherine Jolly, Karen Saunders, Natalie Allen, Parbir Jagpal, George Provan, Steven Ross, Carole Hunter, Sarah Tearne, Andrew McPherson, Helena Heath, Cian Lombard, Adnan Araf, Emily Dixon, Amy Hatch, Jane Moir, Shabana Akhtar
Summary: This study aims to test the feasibility and effectiveness of a pharmacy-based intervention called PHOENIx for people experiencing homelessness. If the pilot study shows positive results, PHOENIx may be implemented as a publicly funded free-to-access service in community pharmacies.
PILOT AND FEASIBILITY STUDIES
(2023)
Meeting Abstract
Obstetrics & Gynecology
V. H. Morton, C. A. Hewitt, E. Dixon, A. Wilson, N. Farmer, P. Hardy, K. Morris
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Hodgetts Morton, C. Hewitt, A. Wilson, E. Dixon, N. Farmer, P. Hardy, K. Morris
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2019)