Article
Immunology
Marta Sanz, Brendan T. Mann, Paul L. Ryan, Alberto Bosque, Daniel J. Pennington, Holger Hackstein, Natalia Soriano-Sarabia
Summary: Under non-pathological conditions, human ?d T cells represent a small fraction of CD3(+) T cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that recognize stress ligands or non-peptide antigens through MHC-independent presentation. Major human ?d T cell subsets, Vd1 and Vd2, expand in response to microbial infection or malignancy, but possess distinct tissue localization, antigen recognition, and effector responses. By comparing highly purified Vd1 and Vd2 cells, this study found distinct genetic and phenotypic signatures that define functional differences in ?d T cell populations, suggesting that Vd1 and Vd2 T cells are different lineages. These findings will facilitate further investigation into the ligand specificity and unique role of Vd1 and Vd2 cells in early immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Rui Dai, Xiaopei Huang, Yiping Yang
Summary: This study demonstrates the critical role of gamma delta T cells in promoting the CD8(+) T cell response to VV infection. Gamma delta T cells are able to present viral antigens and activate CD8(+) T cells, with MyD88 signaling playing a key role in this process. Understanding the regulation of adaptive T cell response by gamma delta T cells may provide insight for the development of more effective vaccine strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Marta Sanz, Brendan T. Mann, Alisha Chitrakar, Natalia Soriano-Sarabia
Summary: COVID-19 is a complex disease caused by SARS-CoV-2, and the immune response to the disease can vary. The role of gamma delta T cells in COVID-19 has not been extensively studied, but they may contribute to the control of infection in mild to moderate clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Seon-Hee Kim, Eunjung Cho, Yu Kim, Chungyong Han, Beom K. Choi, Byoung S. Kwon
Summary: The study demonstrates that post-conditioning treatment with anti-CD4 can enhance the anti-tumor efficacy of adoptive T cell therapy (ACT) by promoting the expansion of IL-18R alpha(hi) CD8(+) T cells. This combination treatment accelerates proliferation and differentiation of tumor-reactive CD8(+) T cells and improves tumor suppression and host survival. The enrichment of polyfunctional IL-18R alpha(hi) CD8(+) T cells plays a key role in the induced tumor suppression, mediated by IL-18 signaling and TCR-MHC I interaction.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Jonathan Caron, Laura Alice Ridgley, Mark Bodman-Smith
Summary: Emerging evidence suggests that gamma delta T cells play a crucial role in the immune response to viral infections by detecting viruses early and triggering antiviral functions. Activating the antiviral potential of gamma delta T cells could be harnessed to prevent or treat viral infections effectively.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Nathalie Guriec, Frederick Bussy, Christelle Gouin, Olivier Mathiaud, Matthieu Le Goff, Jacques Delarue, Pi Nyvall Collen
Summary: Chicken gamma delta T lymphocytes are activated in response to Salmonella immunization and Newcastle disease virus vaccination, indicating a protective immune response. A purified ulvan extract activates chicken immune cells through TLR2 and TLR4 receptors. In vivo administration of ulvan extract results in increased membrane expression of Major Histocompatibility Complex class 2 on day 2, suggesting activation or priming of gamma delta T lymphocytes.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Article
Immunology
Robert Hudecek, Barbora Kohlova, Ingrid Siskova, Martin Piskacek, Andrea Knight
Summary: The study found variable levels of Vδ1 and Vδ2 γ-δT cells in patients with endometriosis, which exhibit inherent cytotoxic reactivity against endometrial tumor cells. It was also discovered that blocking of EphA2 expression significantly inhibited the killing of endometrial tumors mediated by Vδ1 γ-δT cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhenhua Li, Quanli Yang, Xin Tang, Yiming Chen, Shanshan Wang, Xiaojie Qi, Yawen Zhang, Zonghua Liu, Jing Luo, Hui Liu, Yongbing Ba, Lianxia Guo, Baojian Wu, Fang Huang, Guangchao Cao, Zhinan Yin
Summary: This study explores the heterogeneity of gamma delta T cells in different tissues and uncovers potential regulatory mechanisms. It identifies a novel subset of immature gamma delta T cells localized to the thymus and validates the circadian transcription factor NR1D1 as a negative regulator of gamma delta T17 cell differentiation.
Article
Multidisciplinary Sciences
Mikhael D. Manurung, Sanne E. de Jong, Yvonne Kruize, Yoanne D. Mouwenda, Madeleine Eunice Betouke Ongwe, Yabo Josiane Honkpehedji, Jeannot Frezus Zinsou, Jean Claude Dejon-Agobe, Stephen L. Hoffman, Peter G. Kremsner, Ayola Akim Adegnika, Rolf Fendel, Benjamin Mordmuller, Meta Roestenberg, Bertrand Lell, Maria Yazdanbakhsh
Summary: Controlled human malaria infection using cryopreserved non-attenuated Plasmodium falciparum sporozoites provides insights into naturally acquired immunity. The study found that some African individuals have the ability to control parasitemia, which may be associated with the activity of specific types of T cells.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Eliza Mari Kwesi-Maliepaard, Heinz Jacobs, Fred van Leeuwen
Summary: T-AIM cells are a subset of memory T cells that develop memory features independently of antigen exposure. They exhibit characteristics similar to conventional memory cells, including antigen-specific responses and responsiveness to innate stimuli. T-AIM cells are suggested to provide additional levels of protection against infections and cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Immunology
Guo-Qing Li, Jiliang Xia, Weihong Zeng, Weijia Luo, Logen Liu, Xi Zeng, Deliang Cao
Summary: The intestinal mucosa of mammals, as an effective immune system, contains rare γδT cells that can rapidly produce cytokines and growth factors. These cells play key roles in maintaining epithelial homeostasis, immune surveillance, and even recovery from diseases like ischemic stroke.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Fisheries
Miaomiao Wu, Qianling Jiang, Ali Nazmi, Jie Yin, Guan Yang
Summary: Pigs are important domestic livestock and studying their immune system is crucial for improving swine vaccine efficacy. Pig models are excellent for immunological studies due to their similarities to humans. Unconventional T cells are a critical component of the porcine immune system and show distinct characteristics compared to conventional T cells.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Immunology
Alexandra L. Morrison, Sally Sharpe, Andrew D. White, Mark Bodman-Smith
Summary: Research suggests that the BCG vaccine could be a valuable tool in combating new SARS-CoV-2 variants by providing broad protection, including against respiratory viruses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Anne B. C. Cherry, Nicholas A. Gherardin, Hafiz I. Sikder
Summary: This minireview explores the biology of gamma delta T cells, including their unique ability to recognize intracellular disturbances and non-peptide-based antigens, and proposes a framework for understanding gamma delta T cell-inspired therapeutic strategies in cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Guoxing Tang, Min Huang, Ying Luo, Wei Liu, Qun Lin, Liyan Mao, Shiji Wu, Zhigang Xiong, Hongyan Hou, Ziyong Sun, Feng Wang
Summary: This study reveals that COVID-19 deceased patients exhibit immune dysregulation, including increased neutrophils and IL-6, sustained low levels of CD8(+) T cells, NK cells, and dendritic cells. Among the immunological parameters, M-MDSCs show the best performance in predicting COVID-19 mortality.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Loic Raffray, Ross J. Burton, Sarah E. Baker, Matt P. Morgan, Matthias Eberl
Article
Urology & Nephrology
Catriona Goodlad, Sophiamma George, Shella Sandoval, Stephen Mepham, Gita Parekh, Matthias Eberl, Nicholas Topley, Andrew Davenport
KIDNEY INTERNATIONAL
(2020)
Article
Immunology
John Davis Coakley, Eamon P. Breen, Ana Moreno-Olivera, Alhanouf I. Al-Harbi, Ashanty M. Melo, Brian O'Connell, Ross McManus, Derek G. Doherty, Thomas Ryan
Article
Immunology
Ariadni Kouzeli, Paul J. Collins, Mieke Metzemaekers, Max Meyrath, Martyna Szpakowska, Marc Artinger, Sofie Struyf, Paul Proost, Andy Chevigne, Daniel F. Legler, Matthias Eberl, Bernhard Moser
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Pathology
Mark J. Ponsford, Ross J. Burton, Leitchan Smith, Palwasha Y. Khan, Robert Andrews, Simone Cuff, Laura Tan, Matthias Eberl, Ian R. Humphreys, Farbod Babolhavaeji, Andreas Artemiou, Manish Pandey, Stephen R. A. Jolles, Jonathan Underwood
Summary: The study found that the extended laboratory testing panel did not provide significant additional prognostic value for COVID-19 positive patients, suggesting that laboratory testing should be targeted to patients with specific clinical indications.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Urology & Nephrology
Hannah Kaminski, Lionel Couzi, Matthias Eberl
Summary: Unconventional T cells, including MAIT cells, NKT cells, gamma delta T cells, play important roles in kidney inflammatory and autoimmune responses. They have potential clinical applications as therapeutic targets and diagnostic biomarkers in kidney diseases. Their responsiveness to microbial pathogens and contribution to viral clearance suggest their utility in immune monitoring and adoptive immunotherapy.
NATURE REVIEWS NEPHROLOGY
(2021)
Article
Biochemical Research Methods
Ross J. Burton, Raya Ahmed, Simone M. Cuff, Sarah Baker, Andreas Artemiou, Matthias Eberl
Summary: Cytometry analysis has advanced in acquiring a larger number of parameters in single experiments, leading to the development of new computational methodologies. CytoPy is a Python framework for automated cytometry data analysis, demonstrating its ability to phenotype T cell subsets and analyze local inflammatory infiltrates. Despite the success of algorithms and tools in cytometry bioinformatics, CytoPy aims to promote widespread adoption in the scientific community by providing an open-source platform.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Review
Oncology
Bernhard Moser
Summary: Antibodies targeting immune checkpoint molecules have improved cancer therapy. CCR8, a chemokine receptor highly expressed on suppressive immune cells, is a potential target in cancer therapy.
Article
Biology
Ceri Alan Fielding, Pragati Sabberwal, James C. Williamson, Edward J. D. Greenwood, Thomas W. M. Crozier, Wioleta Zelek, Jeffrey Seow, Carl Graham, Isabella Huettner, Jonathan D. Edgeworth, David A. Price, Paul B. Morgan, Kristin Ladell, Matthias Eberl, Ian R. Humphreys, Blair Merrick, Katie Doores, Sam J. Wilson, Paul J. Lehner, Eddie C. Y. Wang, Richard J. Stanton
Summary: The outcome of infection depends on the ability of viruses to manipulate the infected cells and the immune response. Understanding this process is crucial for understanding disease progression and immunity. SARS-CoV-2 can antagonize innate immunity and decrease NK cell activation through modulation of protein synthesis. Antibody-dependent NK cell activation plays a significant role in disease, and vaccine-induced ADNKA is different from natural infection-induced ADNKA.
Editorial Material
Oncology
Bernhard Moser
Article
Cell Biology
Matthias Eberl, Natalie Joseph-Williams, Claire Nollett, Jim Fitzgibbon, Sarah Hatch
Summary: In biomedical research, public engagement and public involvement are crucial for researchers to demonstrate the value of science to society and improve the research process. This article outlines the benefits of public engagement and involvement for researchers, the public, and society as a whole. It provides solutions for overcoming challenges and encourages a cultural shift towards embedding public engagement and involvement in the academic environment.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Editorial Material
Immunology
Bruno Silva-Santos, Julie C. Ribot, Erin J. Adams, Benjamin E. Willcox, Matthias Eberl
Summary: This article introduces the 10th International gamma delta T cell conference held in Lisbon, Portugal in June 2023, which brought together researchers from various fields studying the role of gamma delta T cells in health and disease.
Article
Gastroenterology & Hepatology
S. M. Cuff, N. Reeves, E. Lewis, E. Jones, S. Baker, A. Karategos, R. Morris, J. Torkington, M. Eberl
Summary: This pilot study demonstrates that a simple immune signature in surgical drain fluid could accurately diagnose an anastomotic leak at 48 h postoperatively using instrumentation that is already widely available in hospital clinical laboratories.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Biochemical Research Methods
Ross J. Burton, Simone M. Cuff, Matt P. Morgan, Andreas Artemiou, Matthias Eberl
Summary: We present a novel ensemble clustering methodology based on geometric median clustering with weighted voting (GeoWaVe). Compared to graph ensemble clustering methods that have gained popularity in single-cell RNA sequencing analysis, GeoWaVe performed favourably on different sets of high-dimensional mass and flow cytometry data. Our findings provide proof of concept for the power of consensus methods to make the analysis, visualization and interpretation of cytometry data more robust and reproducible.
Article
Clinical Neurology
Simone M. Cuff, Joseph P. Merola, Jason P. Twohig, Matthias Eberl, William P. Gray
BRAIN COMMUNICATIONS
(2020)
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)