Article
Oncology
Madelon Dijkstra, Sanne Nieuwenhuizen, Robbert S. Puijk, Florentine E. F. Timmer, Bart Geboers, Evelien A. C. Schouten, Jip Opperman, Hester J. Scheffer, Jan J. J. de Vries, Rutger-Jan Swijnenburg, Kathelijn S. Versteeg, Birgit I. Lissenberg-Witte, M. Petrousjka van den Tol, Martijn R. Meijerink
Summary: The study compared the safety, efficacy, and survival outcomes of repeat thermal ablation versus repeat partial hepatectomy in patients with recurrent colorectal liver metastases. Results showed that there were no significant differences in terms of overall survival, recurrence rates, and complications between the two treatment modalities, but patients who underwent repeat thermal ablation had a shorter length of hospital stay.
Article
Oncology
Madelon Dijkstra, Sanne Nieuwenhuizen, Robbert S. Puijk, Florentine E. F. Timmer, Bart Geboers, Evelien A. C. Schouten, Jip Opperman, Hester J. Scheffer, Jan J. J. de Vries, Kathelijn S. Versteeg, Birgit Lissenberg-Witte, Martijn R. Meijerink, Monique Petrousjka van den Tol
Summary: This study found that adding neoadjuvant chemotherapy before repeat local treatment for colorectal liver metastases did not improve survival rates, recurrence rates, or impact complications and hospital stay duration. The results do not support routine use of neoadjuvant chemotherapy before repeat local treatment.
Article
Oncology
Madelon Dijkstra, Susan van der Lei, Robbert S. Puijk, Hannah H. Schulz, Danielle J. W. Vos, Florentine E. F. Timmer, Hester J. Scheffer, Tineke E. Buffart, M. Petrousjka van den Tol, Birgit I. Lissenberg-Witte, Rutger-Jan Swijnenburg, Kathelijn S. Versteeg, Martijn R. Meijerink
Summary: Thermal ablation is safe and effective for the treatment of small-size unresectable colorectal liver metastases (CRLM). This comparative study analyzed the outcomes of intermediate-size versus small-size CRLM and found no significant difference in overall survival between the two groups. However, the small-size group had better local control. The study also showed that thermal ablation improved the long-term local control of intermediate-size CRLM over time.
Article
Medicine, General & Internal
Noemi Reboux, Valerie Jooste, Juste Goungounga, Michel Robaszkiewicz, Jean-Baptiste Nousbaum, Anne-Marie Bouvier
Summary: This study analyzed the temporal patterns and outcomes of synchronous and metachronous liver metastases from colorectal cancer using a population-based cohort study in France. The incidence of synchronous liver metastases remained relatively stable over time, while the probability of developing metachronous liver metastases decreased. Survival rates were significantly higher for patients with metachronous liver metastases compared to synchronous metastases. The differences in the epidemiological features of synchronous and metachronous liver metastases may have implications for future clinical trials.
Article
Oncology
Sanne Nieuwenhuizen, Madelon Dijkstra, Robbert S. Puijk, Florentine E. F. Timmer, Irene M. Nota, Jip Opperman, Bente van den Bemd, Bart Geboers, Alette H. Ruarus, Evelien A. C. Schouten, Jan J. J. de Vries, Hester J. Scheffer, Anne M. van Geel, Jan Hein T. M. van Waesberghe, Rutger-Jan Swijnenburg, Kathelijn S. Versteeg, Birgit Lissenberg-Witte, M. Petrousjka van den Tol, Cornelis J. A. Haasbeek, Martijn R. Meijerink
Summary: Vaginal epithelial shedding is a common gynecological issue that may result from the loss of vaginal epithelial cells. Treatment can involve medication or surgery, depending on the severity of the condition.
Article
Medicine, General & Internal
Hou-Ying Cheng, Kai-Wen Huang, Jin-Tung Liang, Been-Ren Lin, John Huang, Ji-Shiang Hung, Chi-Ling Chen
Summary: Multi-RFA and hepatectomy provide similar survival benefits for resectable colorectal cancer liver metastases patients, while systemic treatment has inferior outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Mariana I. Chavez, Sepideh Gholami, Bradford J. Kim, Georgios A. Margonis, Cecilia G. Ethun, Susan Tsai, Kathleen K. Christians, Callisia Clarke, Harveshp Mogal, Shishir K. Maithel, Timothy M. Pawlik, Michael I. D'Angelica, Thomas A. Aloia, Daniel Eastwood, T. Clark Gamblin
Summary: This study is the largest TSH series in the US and demonstrates evidence of safety and feasibility in the management of bilateral CRLM. Outcomes are influenced by margin status and operative estimated blood loss (EBL).
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Iwan Paolucci, Yuan-Mao Lin, Yoshikuni Kawaguchi, Harufumi Maki, A. Kyle Jones, Marco Calandri, Scott Kopetz, Timothy E. Newhook, Kristy K. Brock, Jean-Nicolas Vauthey, Bruno C. Odisio
Summary: This study found that genomic alterations are associated with different progression patterns and the likelihood of receiving salvage LRT following percutaneous thermal ablation of CLM.
BRITISH JOURNAL OF CANCER
(2023)
Article
Surgery
Rodrigo Blanco Dumarco, Gilton Marques Fonseca, Fabricio Ferreira Coelho, Vagner Birk Jeismann, Fabio Ferrari Makdissi, Jaime Arthur Pirolla Kruger, Sergio Carlos Nahas, Paulo Herman
Summary: This study evaluated the outcomes and prognostic factors for patients with >= 4 colorectal liver metastases who underwent liver resection. The results showed that despite tumor recurrence, a significant number of patients experienced long-term survival, indicating the chronic nature of the disease.
Article
Oncology
Haozhe Huang, Dezhong Zheng, Hong Chen, Chao Chen, Ying Wang, Lichao Xu, Yaohui Wang, Xinhong He, Yuanyuan Yang, Wentao Li
Summary: In this study, a novel multimodal data fusion model based on radiomics features and clinical variables was developed to objectively and accurately assess the immediate efficacy of radiofrequency ablation (RFA) on colorectal cancer (CRC) lung metastases. The model was constructed using a random forest classifier and achieved high accuracy, AUC value, sensitivity, and specificity in predicting the immediate efficacy of RFA. The results demonstrated the efficiency of this multimodal data fusion model for evaluating the efficacy of RFA in CRC lung metastases.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martijn R. Meijerink, Alette H. Ruarus, Laurien G. P. H. Vroomen, Robbert S. Puijk, Bart Geboers, Sanne Nieuwenhuizen, Bente A. T. van den Bemd, Karin Nielsen, Jan J. J. de Vries, Krijn P. van Lienden, Birgit Lissenberg-Witte, M. Petrousjka van den Tol, Hester J. Scheffer
Summary: Irreversible electroporation is an effective and relatively safe treatment for colorectal liver metastases measuring 5.0 cm or smaller, especially when unsuitable for surgical resection or thermal ablation. The study showed a 1-year LTP-free survival rate of 68% post-IRE, with good local control and a median overall survival of 2.7 years.
Review
Oncology
Gabriel D. Ivey, Fabian M. Johnston, Nilofer S. Azad, Eric S. Christenson, Kelly J. Lafaro, Christopher R. Shubert
Summary: Colorectal cancer is one of the most common types of cancer, and at least half of patients diagnosed with it will develop metastatic liver disease. Surgical resection of colorectal liver metastases is considered potentially curative, but it is underutilized despite the availability of various operative strategies. Differing views on resectability may contribute to this underutilization.
Article
Oncology
Lariza Marie Canseco, Yueh-Wei Liu, Chien-Chang Lu, Ko-Chao Lee, Hong-Hwa Chen, Wan-Hsiang Hu, Kai-Lung Tsai, Yao-Hsu Yang, Chih-Chi Wang, Chao-Hung Hung
Summary: Aggressive local treatment (hepatectomy and/or radiofrequency ablation) provides survival advantages over systemic therapy alone among patients with colorectal cancer liver metastases.
Article
Oncology
Hongjie Fan, Xiaoyan Wang, Jiali Qu, Wei Lu, Shufeng Xu, Xia Wu, Jingya Xia, Yanhua Zhang, Jihong Sun, Xiaoming Yang
Summary: The study demonstrates that percutaneous radiofrequency ablation is a safe and effective technique for the local tumor control of subcapsular colorectal cancer liver metastases. Factors such as minimal ablative margin, tumor size, and technical effectiveness were found to be predictors of local tumor progression.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Ziyi Yang, Xia Lyu, Huilin Yang, Bingbing Wang, Dan Xu, Lingyi Huo, Runzi Zhang, Yingjun Huang, Benshu Diao
Summary: The study showed that combining RFA with chemotherapy may offer better treatment outcomes for patients with lung cancer or pulmonary metastases compared to chemotherapy alone or RFA alone. Further investigation is needed to specifically compare the efficacy of RFA and/or chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Georgios Antonios Margonis, Alessandra Pulvirenti, Vicente Morales-Oyarvide, Stefan Buettner, Nikolaos Andreatos, Carsten Kamphues, Katharina Beyer, Jane Wang, Martin E. Kreis, John L. Cameron, Matthew J. Weiss, Kevin Soares, Carlos Fernandez-del Castillo, Peter J. Allen, Christopher L. Wolfgang
Summary: This study validated the applicability of the 7th and 8th editions of the AJCC staging system for IPMN-associated PDAC. The 8th edition introduced T1a sub-staging and a new distinction between N1 and N2, both of which showed mixed results. The findings support the use of the AJCC 8th edition in the IPMN-associated PDAC population, but suggest that certain cutoffs may need to be revisited.
Article
Surgery
Yutaka Endo, Laura Alaimo, Henrique Araujo Lima, Diamantis I. Tsilimigras, J. Madison Hyer, Alfredo Guglielmi, Andrea Ruzzenente, Sorin Alexandrescu, George Poultsides, Kazunari Sasaki, Federico Aucejo, Timothy M. Pawlik
Summary: In this study, we used the win ratio (WR) to compare the outcomes of simultaneous and staged surgical treatment for synchronous colorectal liver metastases (sCRLM). The results showed that staged resection had a higher WR than simultaneous resection, indicating its superiority for treating sCRLM.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Mariana Chavez-Villa, Luis I. Ruffolo, Bandar M. Al-Judaibi, Masato Fujiki, Koji Hashimoto, Jeffrey Kallas, Choon Hyuck David Kwon, Amit Nair, Mark S. Orloff, Karen Pineda-Solis, Roma Raj, Kazunari Sasaki, Koji Tomiyama, Federico Aucejo, Roberto Hernandez-Alejandro
Summary: This study aimed to describe the rate of occult carcinoma deposits in total hepatectomy specimens from patients treated with liver transplant for colorectal liver metastases. The results showed that a complete radiographic response does not reliably predict a complete pathologic response, and residual invasive cancer can be found in disappearing tumors after resection. Liver transplant is considered a promising treatment option for patients with unresectable colorectal liver metastases.
Article
Oncology
Ioannis Pozios, Nina A. Hering, Emily Guenzler, Marco Arndt, Sefer Elezkurtaj, Thomas Knosel, Christiane J. Bruns, Georgios A. Margonis, Katharina Beyer, Hendrik Seeliger
Summary: The study found that gp130 is expressed in the epithelium of most human PDAC, but is rarely expressed in the stroma. The small molecule gp130 inhibitor SC144 potently inhibits PDAC progression in vitro and may block IL-6 or OSM/gp130/STAT3 signaling. These results suggest gp130 as a potential new drug target for pancreatic cancer therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Immunology
Emily Reznicek, Kazunari Sasaki, Bryce Montane, Ariel Sims, Jonathan Beard, Maan Fares, Vikram Sharma, Jacek Cywinski, Christiano Quintini, Federico N. Aucejo, Bijan Eghtesad, Charles M. Miller, K. V. Narayanan Menon
Summary: Patients with preexisting coronary artery disease have a higher risk of death, specifically cardiovascular-related death, before liver transplantation. This risk is increased when nonalcoholic steatohepatitis and coronary artery disease coexist.
Article
Gastroenterology & Hepatology
Chase J. Wehrle, Roma Raj, Nihal Aykun, Danny Orabi, Bassam Estfan, Suneel Kamath, Smitha Krishnamurthi, Masato Fujiki, Koji Hashimoto, Cristiano Quintini, David Choon Hyuck Kwon, Teresa Diago-Uso, Kazunari Sasaki, Federico N. Aucejo
Summary: Colorectal cancer is a leading cause of cancer-related death worldwide. Liver transplantation is emerging as a valid surgical option for selected patients with unresectable colorectal cancer liver metastases (CRLM). However, the utility and significance of liquid biopsy ctDNA in evaluating residual disease in these patients remains unclear. This study aimed to evaluate the peri-operative assessment of ctDNA in patients undergoing liver transplantation for CRLM.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Yutaka Endo, Belisario Ortiz Rueda, Selamawit Woldesenbet, Muhammad Musaab Munir, Henrique A. Lima, Erryk S. Katayama, Chanza F. Shaikh, Alfredo Guglielmi, Andrea Ruzzenente, Luca Aldrighetti, Sorin Alexandrescu, Minoru Kitago, George Poultsides, Kazunari Sasaki, Federico Aucejo, Timothy M. Pawlik
Summary: The timing of recurrence and tumor burden score at the time of recurrence have an impact on overall survival among patients undergoing repeat hepatectomy for colorectal liver metastases.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sheraz Yaqub, Georgios Antonios Margonis, Kjetil Soreide
Summary: For patients with primary colon or rectal cancer and synchronous liver metastases, there are various treatment strategies to consider. The decision regarding surgery depends on several factors. Designing a trial to investigate the optimal approach for simultaneous resection of colon or rectal cancer with liver metastases is challenging due to the complexity of the procedures and the need for a reasonable endpoint.
Meeting Abstract
Immunology
Yuki Imaoka, Miho Akabane, Masahiro Ohira, Hideki Ohdan, Kazunari Sasaki
Meeting Abstract
Immunology
Yuki Imaoka, Miho Akabane, Masahiro Ohira, Hideki Ohdan, Kazunari Sasaki
Article
Gastroenterology & Hepatology
Alessandro Paro, J. Madison Hyer, Brandon S. Avery, Diamantis I. Tsilimigras, Fabio Bagante, Alfredo Guglielmi, Andrea Ruzzenente, Sorin Alexandrescu, George Poultsides, Kazunari Sasaki, Federico Aucejo, Timothy M. Pawlik
Summary: By comparing CRLM patients, it is found that patients undergoing laparoscopic hepatectomy have a higher win ratio, with significant advantages in terms of tumor burden and short-term outcomes. Therefore, laparoscopic liver resection should be strongly considered as a preferred approach in CRLM patients.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Meeting Abstract
Pediatrics
Tetsuya Tajima, Daniel Bernstein, Scott D. Boyd, Dita Gratzinger, Grant Lum, Kazunari Sasaki, Brent Tan, Clare J. Twist, Kenneth Weinberg, Mark A. Robien, Merideth Brown, Brian Armstrong, Dev Desai, George Mazariegos, Clifford Chin, Thomas M. Fishbein, Akin Tekin, Robert S. Venick, Olivia M. Martinez, Sheri M. Krams, Carlos O. Esquivel
PEDIATRIC TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
Ahmed Nassar, Marty Sellers, Humberto Bohorquez, Mark Hobeika, David Lee, Farjad Siddiqui, Musab Alebrahim, Robert Cannon, Nikole Neidlinger, Gennaro Selvaggi, Peter Abt, Kazunari Sasaki, Martin Montenovo
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
Suk Hong, Joshua Badshah, Ahmed Aliwaisi, Kazunari Sasaki, Timothy Pruett, Marc Melcher, Clark Bonham, Amy Gallo, Olivia Martinez, Sheri Krams, K. Thomas Pham, Stephan Busque, Andrea Reitsma, Carlos Esquivel, Varvara Kirchner
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Jason Yang, Yutaka Endo, Zorays Moazzam, Henrique A. Lima, Selamawit Woldesenbet, Laura Alaimo, Lovette Azap, Chanza F. Shaikh, Muhammad Musaab Munir, Erryk Katayama, Kazunari Sasaki, Timothy M. Pawlik
Summary: The reasons for geographic disparities in liver-related mortality across the US are explored in this study. It is found that travel distance to liver transplantation programs and social vulnerability have an impact on county differences in liver-related mortality. Counties with higher social vulnerability are associated with higher liver-related mortality, while longer travel distances to transplant centers are associated with higher mortality.
CLINICAL TRANSPLANTATION
(2023)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)