Article
Neurosciences
Chen Liu, Fangzhen Shan, Feng Gao, Qingjie Ji, Yunfeng Chen, Changying Wang, Zihao Wang, Pengcheng Gao, Zhanyun Lv, Yuzhong Wang
Summary: The expression of DAP12 in Schwann cells and its roles in the peripheral nervous system (PNS) were investigated. DAP12-deficiency mice showed age-related motor deficits and thinner myelin, but faster clinical recovery after sciatic nerve crush injury. Proteomic analysis revealed differentially expressed proteins related to myelin loss and macrophage accumulation in DAP12 KO mice. DAP12 deletion promoted the phenotype conversion of macrophages from M1 to M2, suggesting dual roles of DAP12 in the PNS.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Chun Yao, Qihui Wang, Yaxian Wang, Jiancheng Wu, Xuemin Cao, Yan Lu, Yanping Chen, Wei Feng, Xiaosong Gu, Xin-Peng Dun, Bin Yu
Summary: Our study identified lncRNA loc680254 as a potential modulator for Schwann cell proliferation, which may act as a microRNA sponge to regulate the expression of mitosis-related genes and proteins. Experimental results showed that loc680254 could be targeted to develop novel therapeutic strategies for peripheral nerve repair.
Article
Cell & Tissue Engineering
Qunzhou Zhang, Justin C. Burrell, Jincheng Zeng, Faizan Motiwala, Shihong Shi, D. Kacy Cullen, Anh D. Le
Summary: This study generated gingiva-derived mesenchymal stem cell (GMSC)-repopulated nerve protectors and evaluated their therapeutic effects in a crush injury model. The results showed that the Schwann-like cells converted from GMSCs were able to promote functional recovery and axonal regeneration of injured sciatic nerves.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Neurosciences
Guoliang Wang, Zhihua Wang, Shuang Gao, Yang Wang, Qing Li
Summary: The study confirmed the reparative effect of curcumin on sciatic nerve injury, and discovered that its mechanism may be related to the regulation of Schwann cell proliferation and myelination by Runx2.
NEUROSCIENCE LETTERS
(2022)
Article
Chemistry, Medicinal
Haili Xiao, Chao Wei, Huiying Liu, Zhiqiang Li, Cihua Zheng, Jun Luo
Summary: The natural drug lentinan has been found to regulate autophagy, promoting the clearance of myelin debris and enhancing nerve regeneration. The study demonstrated that lentinan activates the AMPK/mTOR signaling pathway, accelerating autophagic flux and promoting the phagocytosis of myelin debris by Schwann cells. These findings suggest that lentinan may be a cost-effective and natural treatment for peripheral nerve injury.
PHYTOTHERAPY RESEARCH
(2023)
Article
Genetics & Heredity
Jinyuan Zhang, Zhi Mei, Wanxiang Yao, Chenyi Zhao, Shutong Wu, Jun Ouyang
Summary: Neuropathic pain is a severe condition caused by nerve damage, and its underlying mechanisms are not fully understood. This study identified a novel lncRNA HULC that plays a significant role in the progression of neuropathic pain. The results highlight the potential involvement of the SIX1/HULC axis in the development and progression of neuropathic pain.
Article
Cell Biology
Ruirui Zhang, Qi Chen, Li Huang, Yunsong Zhang, Xinghui Wang, Sheng Yi
Summary: The study analyzed single-cell transcriptional profiling of Schwann cells in neonatal rat sciatic nerves, revealing cellular heterogeneity and dynamic changes. It also identified differentiation trajectory from certain Schwann cell subtypes to others, with functional interpretation showing genetic signatures of DNA replication and acquisition of mesenchymal traits in subtype 3 Schwann cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biology
Sonia Taib, Noel Lamande, Sabrina Martin, Fanny Coulpier, Piotr Topilko, Isabelle Brunet
Summary: Peripheral nerves rely on blood vessel invasion to ensure their function, which occurs during both embryonic development and the post-natal period. Netrin-1 promotes nerve invasion by blood vessels via the endothelial receptor UNC5B during embryogenesis, while myelinated Schwann cells negatively regulate intra-nervous vascularization during the post-natal period.
Article
Orthopedics
Chen Yu, Xiaoxu Wang, Jian Qin
Summary: Necrostatin-1 (Nec-1) can reduce peripheral nerve lesions and protect Schwann cells and axons by inhibiting necroptosis. It also reduces inflammation and oxidative stress by inhibiting RIP1.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Svetlana Demyanenko, Maria A. Pitinova, Yulia N. Kalyuzhnaya, Andrey M. Khaitin, Svetlana A. Batalshchikova, Natalya M. Dobaeva, Yulia A. Shevtsova, Kirill Goryunov, Egor Y. Plotnikov, Svetlana G. Pashkevich, Gennady T. Sukhikh, Denis N. Silachev
Summary: Peripheral nerve injury is a significant medical problem without effective treatment currently. However, the use of multipotent mesenchymal cells (MSCs)-derived extracellular vesicles (EVs) shows promise in promoting the regeneration of peripheral nerves after injury. In a rat model of sciatic nerve injury, the application of MSCs-EVs gel significantly reduced muscle atrophy and improved functional recovery. The results suggest that this therapeutic approach may be efficient for the treatment of acute peripheral nervous system injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Waleed M. Renno, Mohammad Afzal, Bincy Paul, Divya Nair, Jijin Kumar, Jassim M. Al-Hassan
Summary: Preparations from the epidermal gel secretion of Arabian Gulf catfish showed potent anti-inflammatory and healing properties in clinical trials for diabetic foot ulcers and other disorders. A unique protein and lipid preparation from the catfish secretion accelerated the healing of nerve injuries in rats, enhancing neurobehavioral performance and histomorphological regeneration. SPF-FB treatment decreased neurobehavioral deficits, promoted axonal regeneration, and protected spinal neurons by modulating astrocytic activity and GAP-43 expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sailing Chen, Qianqian Chen, Xiaojiao Zhang, Yinying Shen, Xinyu Shi, Xiu Dai, Sheng Yi
Summary: Peripheral nerves have limited ability to regenerate after injury. The growth factor amphiregulin (AREG) is upregulated in Schwann cells of injured sciatic nerves and stimulates their proliferation and migration. Schwann cell-secreted AREG promotes neurite outgrowth and axon elongation. Administering AREG to injured nerves facilitates Schwann cell proliferation, cord formation, and axon regrowth. Overall, our study identifies AREG as an important neurotrophic factor and offers a promising therapeutic approach for peripheral nerve injuries.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Na Zhang, Junquan Lin, Jiah Shin Chin, Christian Wiraja, Chenjie Xu, Duncan Angus McGrouther, Sing Yian Chew
Summary: This study investigated the potential of pathway inhibition in promoting peripheral nervous system regeneration and discovered the therapeutic window for using pathway inhibitors. By delivering Wnt inhibitors, WIFI was found to promote sciatic nerve regeneration. Furthermore, the optimal timing for treating with Wnt inhibitors was revealed.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Neurosciences
Xiangling Li, Tieyuan Zhang, Chaochao Li, Wenjing Xu, Yanjun Guan, Xiaoya Li, Haofeng Cheng, Shengfeng Chen, Boyao Yang, Yuli Liu, Zhiqi Ren, Xiangyu Song, Zhibo Jia, Yu Wang, Jinshu Tang
Summary: Low-frequency electrical stimulation (ES) promotes nerve regeneration by accelerating Wallerian degeneration (WD) and upregulating the expression of neurotrophic factors, leading to accelerated early axonal and vascular regeneration while delaying muscle atrophy.
Article
Biochemistry & Molecular Biology
Fernando Gisbert Roca, Luis Gil Santos, Manuel Mata Roig, Lara Milian Medina, Cristina Martinez-Ramos, Manuel Monleon Pradas
Summary: This study presents a novel multimodular nerve guidance conduit for the treatment of large nerve damages. The conduit consists of aligned PLA microfibers and HA conduits that retain pre-seeded auxiliary cells. The results demonstrate that this multimodular approach is effective for promoting nerve regeneration and provides new surgical solutions in this field.
Article
Biochemistry & Molecular Biology
Yonghua Liu, Weijie Wu, Huiguang Yang, Zhengming Zhou, Xiaojian Zhu, Chi Sun, Yuxi Liu, Zhaohui Yu, Yuyan Chen, Youhua Wang
NEUROCHEMICAL RESEARCH
(2017)
Article
Cell Biology
Weiwei Sun, Rongqin Qin, Rui Wang, Dazhi Ding, Zhaohui Yu, Yuxi Liu, Ruilong Hong, Zhen Cheng, Youhua Wang
Article
Biochemistry & Molecular Biology
Yuxi Liu, Shuyao Wang, Dazhi Ding, Zhaohui Yu, Weiwei Sun, Youhua Wang
NEUROCHEMICAL RESEARCH
(2018)
Article
Anatomy & Morphology
Zhaohui Yu, Hua Xu, Hailin Wang, Youhua Wang
Correction
Cell Biology
Weiwei Sun, Rongqing Qin, Rui Wang, Dazhi Ding, Zhaohui Yu, Yuxi Liu, Ruilong Hong, Zhen Cheng, Youhua Wang
Article
Biochemistry & Molecular Biology
Dazhi Ding, Peipei Zhang, Yuxi Liu, Yi Wang, Weiwei Sun, Zhaohui Yu, Zhen Cheng, Youhua Wang
NEUROCHEMICAL RESEARCH
(2018)
Article
Cell Biology
Minhao Chen, Yingjuan Li, Longfei Xiao, Guangchun Dai, Panpan Lu, Youhua Wang, Yunfeng Rui
CELL DEATH & DISEASE
(2020)
Article
Orthopedics
Haidong Cui, Kai Chen, Shujun Lv, Chaoqun Yuan, Youhua Wang
Summary: Factors affecting perioperative hidden blood loss in intertrochanteric fractures include internal fixation, age, fracture type, anesthesia method, anticoagulant use, and bone density. Patients at risk for hidden blood loss should be intervened early to prevent complications.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Oncology
Yi Wang, Na Li, Di Tian, Chang-Wu Zhou, You-Hua Wang, Chun Yang, Meng-Su Zeng
Summary: Our study demonstrated that the 9 m6A-related lncRNA signature may serve as a novel predictor in the prognosis of HCC and optimize (ICIs) therapy. SNHG4 plays an oncogenic role in HCC.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Anatomy & Morphology
Xiao Zhang, Weiwei Sun, Weijie Wu, Minhao Chen, Tianyi Ji, Hua Xu, Youhua Wang
Summary: This study investigated the role of Pin1 in the aging of rat knee joint CSPCs. The results showed that Pin1 protein levels were reduced, and senescence-related markers were elevated in long-term in vitro culture. Over-expression of Pin1 reversed cellular senescence, while Pin1 siRNA incorporation promoted senescence. Pin1 deficiency resulted in cell cycle arrest in the G1 phase, indicating lack of proliferation ability, a sign of cellular senescence.
Article
Cell Biology
Tianyi Ji, Minhao Chen, Weiwei Sun, Xiao Zhang, Hao Cai, Youhua Wang, Hua Xu
Summary: This study revealed the crucial role of the JAK-STAT signaling pathway in the senescence of cartilage-derived stem/progenitor cells (CSPCs), suggesting that CSPCs senescence may be an important factor in promoting the development of osteoarthritis.
JOURNAL OF MOLECULAR HISTOLOGY
(2022)
Article
Immunology
Weiwei Sun, Jinquan Ma, Minhao Chen, Weidong Zhang, Chunxiang Xu, Yunyi Nan, Weijie Wu, Xingxing Mao, Xi Cheng, Hao Cai, Jianhua Zhang, Hua Xu, Youhua Wang
Summary: Rheumatoid arthritis is a systemic immune-mediated inflammatory disease that severely affects patients' quality of life. 4-Iodo-6-phenylpyrimidine (4-IPP) has been shown to inhibit inflammation and the proliferative, migratory, and invasive abilities of synovial cells in rheumatoid arthritis. The development of 4-IPP nanospheres allows for targeted delivery and sustained release of 4-IPP, demonstrating potent anti-inflammatory effects and providing a promising therapeutic strategy for rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Weiwei Sun, Xingxing Mao, Weijie Wu, Yunyi Nan, Chunxiang Xu, Youhua Wang, Hua Xu
Summary: In this study, it was found that Cdc37 was upregulated in rheumatoid synovia and promoted the proliferation and migration of RA-FLS through activation of the ERK signaling pathway. In vivo experiments demonstrated that silencing of Cdc37 alleviated RA symptoms and cartilage destruction, suggesting that Cdc37 may serve as a novel target for RA treatment.
Article
Materials Science, Multidisciplinary
Weidong Zhang, Huan Wang, Genglei Chu, Li Yu, Feng Han, Qifan Yu, Youhua Wang, Bin Li
Summary: In this study, micropatterned collagen scaffolds were fabricated to mimic the microstructural features of annulus fibrosus (AF) and mechanically stimulate bone marrow mesenchymal stromal cells (BMSCs). The aligned cells showed enhanced expression of matrix anabolism-related genes and proteins under mechanical loading. Furthermore, Caveolin-1 (CAV1) was found to mediate the nuclear translocation of Yes-associated protein (YAP) in response to external mechanical cues. The biomimetic collagen membranes formed angle-ply and multilayered tissues that showed improved restoration of the disc in a rat model.
APPLIED MATERIALS TODAY
(2023)
Article
Cell Biology
Chi Sun, Yu Sun, Dingjun Jiang, Guofeng Bao, Xinhui Zhu, Dawei Xu, Youhua Wang, Zhiming Cui
CELLULAR IMMUNOLOGY
(2017)