期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 72, 期 12, 页码 2261-2287出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-015-1860-z
关键词
Opportunistic; Fungi; Yeast; Pathogen; Candida; Cryptococcus; Histoplasma; Pneumocystis
资金
- Canadian Institutes of Health Research (CIHR)
- University of Toronto
- Wellcome Trust [096072]
- Ministry of Research and Innovation
- Canada Research Chair in Microbial Genomics and Infectious Disease
- Natural Sciences and Engineering Research Council [355965]
- Canadian Institutes of Health Research [MOP-86452, MOP-119520]
Life-threatening invasive fungal infections are becoming increasingly common, at least in part due to the prevalence of medical interventions resulting in immunosuppression. Opportunistic fungal pathogens of humans exploit hosts that are immunocompromised, whether by immunosuppression or genetic predisposition, with infections originating from either commensal or environmental sources. Fungal pathogens are armed with an arsenal of traits that promote pathogenesis, including the ability to survive host physiological conditions and to switch between different morphological states. Despite the profound impact of fungal pathogens on human health worldwide, diagnostic strategies remain crude and treatment options are limited, with resistance to antifungal drugs on the rise. This review will focus on the global burden of fungal infections, the reservoirs of these pathogens, the traits of opportunistic yeast that lead to pathogenesis, host genetic susceptibilities, and the challenges that must be overcome to combat antifungal drug resistance and improve clinical outcome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据