Article
Immunology
Shi-Peng Li, Jin-Ming Zhang, Xiao-Jie Chen, Guang-Peng Zhou, Jie Sun, Bin Cui, Liu-Xin Zhou, Hai-Ming Zhang, Wei-Tao Que, Li-Ying Sun, Zhi-Jun Zhu
Summary: DPT cells are increased in liver transplant patients, especially in rejection cases. These cells show contiguity with Treg cells and their exhaustion is enhanced by increased PD-1 expression. These findings suggest that DPT cells may play a role in immune tolerance and could be targeted for preventing liver transplant rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Virology
Huiyuan Zhang, Yazhen Wang, Ying Ma, Kang Tang, Chunmei Zhang, Meng Wang, Xiyue Zhang, Manling Xue, Xiaozhou Jia, Haifeng Hu, Na Li, Ran Zhuang, Boquan Jin, Lihua Chen, Yun Zhang, Yusi Zhang
Summary: This study characterized double positive T (DP T) cells in HFRS patients using flow cytometry data combined with scRNA-seq data. Results showed an upregulation of DP T cells in the peripheral blood during HTNV infection, which was correlated with disease stage. The scRNA-seq data clustered and unraveled the gene expression profile of DP T cells.
Review
Biotechnology & Applied Microbiology
Marlene Pluess, Silvia Piantoni, Bjoern Tampe, Alfred H. J. Kim, Peter Korsten
Summary: Advances in the treatment and management of systemic lupus erythematosus have improved patient outcomes, but lupus nephritis remains a major complication. Belimumab has been shown to be superior as an add-on therapy for lupus nephritis, and personalized treatment options are expected with the development of new therapeutic agents.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai
Summary: This study investigated the alteration of oxylipins in the serum of systemic lupus erythematosus (SLE) patients and identified potential biomarkers for SLE classification. The results showed that certain oxylipins were correlated with lupus nephritis (LN) and SLE disease activity. Additionally, a combination of 5 oxylipins was found to have high accuracy in classifying SLE patients. The findings provide insights into the characteristics of SLE and the development of new tools for classification.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Masahiro Nakano, Yukiko Iwasaki, Keishi Fujio
Summary: Studies on SLE have identified several disease-relevant signatures, including the IFN signature, myeloid lineage/neutrophil and plasma cell signatures, and the exhaustion signature in CD8(+) T cells, which are correlated with disease activity, nephritis, and complications of pregnancy. Further research is needed to identify treatment targets and patient stratification in SLE, as well as to understand the molecular heterogeneity and distinct subpopulations involved in the pathogenesis of SLE.
INFLAMMATION AND REGENERATION
(2021)
Article
Urology & Nephrology
Dimas Abdirama, Sebastian Tesch, Anna-Sophie Griessbach, Caroline von Spee-Mayer, Jens Y. Humrich, Ulrik Stervbo, Nina Babel, Christian Meisel, Tobias Alexander, Robert Biesen, Petra Bacher, Alexander Scheffold, Kai-Uwe Eckardt, Falk Hiepe, Andreas Radbruch, Gerd-Rudiger Burmester, Gabriela Riemekasten, Philipp Enghard
Summary: Systemic lupus erythematosus is characterized by loss of tolerance towards nuclear antigens with autoreactive CD4(+) T cells implicated in disease pathogenesis. The frequencies of nuclear antigen specific CD4(+) T cells correlate with disease severity, and these cells produce multiple effector cytokines. These previously unrecognized characteristics support a role for nuclear antigen-specific CD4(+) T cells in systemic lupus erythematosus.
KIDNEY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Magdalena Hagen, Luca Pangrazzi, Lourdes Rocamora-Reverte, Birgit Weinberger
Summary: The expression of CD4 and CD8 co-receptors defines two distinct T cell populations with specialized functions. However, a paradoxical population of CD4(+)CD8(+) double-positive (DP) T cells challenging this paradigm has been found in the peripheral blood. This subset has unique functions and exhibits memory-like features. Strategies to better characterize the role of this minor T cell subset in regulating immune responses are necessary.
Article
Immunology
Ram P. Singh, Bevra H. Hahn, David S. Bischoff
Summary: The study demonstrated the immune modulatory role of pCons peptide in inducing CD8(+) regulatory T cells and characterized their cell surface molecules, gene expression, and protein levels. These findings highlight the potential therapeutic significance of pCons in protecting against systemic lupus erythematosus autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Antonis Fanouriakis, Myrto Kostopoulou, Jeanette Andersen, Martin Aringer, Laurent Arnaud, Sang-Cheol Bae, John Boletis, Ian N. Bruce, Ricard Cervera, Andrea Doria, Thomas Doerner, Richard A. Furie, Dafna D. Gladman, Frederic A. Houssiau, Luis Sousa Ines, David Jayne, Marios Kouloumas, Laszlo Kovacs, Chi Chiu Mok, Eric F. Morand, Gabriella Moroni, Marta Mosca, Johanna Mucke, Chetan B. Mukhtyar, Gyoergy Nagy, Sandra Navarra, Ioannis Parodis, Jose M. Pego-Reigosa, Michelle Petri, Bernardo A. Pons-Estel, Matthias Schneider, Josef S. Smolen, Elisabet Svenungsson, Yoshiya Tanaka, Maria G. Tektonidou, Y. K. Onno Teng, Angela Tincani, Edward M. Vital, Ronald F. van Vollenhoven, Chris Wincup, George Bertsias, Dimitrios T. Boumpas
Summary: The EULAR recommendations for the management of systemic lupus erythematosus (SLE) have been updated based on emerging new evidence. The updated recommendations provide consensus guidance on the use of various medications and treatment strategies to control the disease, as well as recommendations for assessing treatment response and tapering therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Tomohiro Koga, Kunihiro Ichinose, Atsushi Kawakami, George C. Tsokos
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease with IL-17-producing cells playing a key role in its pathogenesis, making them a therapeutic target. Targeting IL-17 for treatment shows promising potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Ping Yang, Rui Xu, Fei Chen, Shanshan Chen, Adeel Khan, Liang Li, Xiaoshan Zhang, Yanbo Wang, Zhipeng Xu, Han Shen
Summary: This study investigates the gut fungal dysbiosis and ecology in patients with SLE and demonstrates the applicability of fungal species as diagnostic tools for SLE. It suggests that the interaction between the gut fungal mycobiome and the host may contribute to the pathogenesis of the disease.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yi-Giien Tsai, Pei-Fen Liao, Kai-Hung Hsiao, Hung-Ming Wu, Ching-Yuang Lin, Kuender D. Yang
Summary: Systemic lupus erythematosus (SLE) is a heterogeneous multisystem inflammatory disease. Immune regulatory cells, particularly Treg subsets, and low-dose IL-2 therapy play important roles in the pathogenesis and treatment of SLE.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Robert Silver, Sabrina Craigo, Flint Porter, Sarah S. Osmundson, Jeffrey A. Kuller, Mary E. Norton
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by relapses and remission. It can affect various organs, with the kidneys, joints, and skin being commonly affected. Immunologic abnormalities, such as the production of antinuclear antibodies, are also characteristic of the disease. This document provides recommendations for the treatment and management of SLE during pregnancy, including the use of medications and the prevention of complications.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Urology & Nephrology
Momin H. Alkhatib, Sam Kant, Steven Menez, Laila Lakhani, Christopher John Sperati, Derek M. Fine, Lois J. Arend, Mohamed G. Atta
Summary: This study compared the clinical and prognostic characteristics of thrombotic microangiopathy (TMA) with class IV lupus nephritis in SLE patients. TMA patients showed significant abnormalities in certain laboratory markers and had a worse prognosis.
JOURNAL OF NEPHROLOGY
(2021)