Review
Cell Biology
Yuxuan Zhong, Xiang Li, Fanglin Wang, Shoushuai Wang, Xiaohong Wang, Xiaohong Tian, Shuling Bai, Di Miao, Jun Fan
Summary: Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. Exosomes play an important role in promoting tissue regeneration and provide new ideas for adipose tissue engineering research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Marie-Laure Mollichella, Violaine Mechin, Dany Royer, Patrick Pageat, Pietro Asproni
Summary: This study successfully isolated olfactory ecto-mesenchymal stem cells from cat olfactory mucosa, demonstrating their stemness features and multilineage differentiation capabilities. These cells hold promising potential for application in feline regenerative medicine.
Review
Cell Biology
Yu Fang, Angelina Olegovna Zekiy, Farhoodeh Ghaedrahmati, Anton Timoshin, Maryam Farzaneh, Amir Anbiyaiee, Seyed Esmaeil Khoshnam
Summary: Trib2 is a pseudo serine/threonine kinase that plays important roles in regulating key signaling pathways and cell fate determination.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Summer A. Helmi, Leili Rohani, Ahmed R. Zaher, Youssry M. El Hawary, Derrick E. Rancourt
Summary: Bone healing is a well-organized process regulated by multiple factors. The Notch signaling pathway plays a significant role in controlling bone mesenchymal stem cell differentiation. Inhibiting the Notch pathway can greatly enhance the differentiation of both embryonic and induced pluripotent stem cells, potentially improving overall healing outcomes. Stem cell transplantations are prominent candidates for treating critical-sized bone defects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lixiang Sun, Xiaowei Zhang, Shuai Wu, Youxi Liu, Christian F. Guerrero-Juarez, Wenjie Liu, Jinwen Huang, Qian Yao, Meimei Yin, Jiacheng Li, Raul Ramos, Yanhang Liao, Rundong Wu, Tian Xia, Xinyuan Zhang, Yichun Yang, Fengwu Li, Shujun Heng, Wenlu Zhang, Minggang Yang, Chi-Meng Tzeng, Chao Ji, Maksim V. Plikus, Richard L. Gallo, Ling-juan Zhang
Summary: By conducting single-cell RNA sequencing on mouse skin, researchers have classified dermal fibroblasts into different non-adipogenic and adipogenic cell states. They have identified IL-1-NF-kB and WNT-b-catenin signaling pathways as regulators of adipogenesis. Neutrophils and WNT activation play roles in wound-induced adipogenesis and lipolysis, respectively, while sustaining WNT activation inhibits adipogenesis and contributes to myofibroblast formation.
Review
Biochemistry & Molecular Biology
Agnieszka Fus-Kujawa, Barbara Mendrek, Anna Trybus, Karolina Bajdak-Rusinek, Karolina L. Stepien, Aleksander L. Sieron
Summary: Induced pluripotent stem cells (iPSCs) show potential in gene therapy and disease modeling. To safely apply this technology in clinical settings, optimal reprogramming factors and vectors must be considered to reduce the risk of insertional tumorigenesis.
Review
Chemistry, Multidisciplinary
Fernando J. Aguilar-Ayala, Fernando J. Aguilar-Perez, Geovanny Nic-Can, Rafael Rojas-Herrera, Gabriela Chuc-Gamboa, David Aguilar-Perez, Beatriz A. Rodas-Junco
Summary: Biomaterials and stem cells are crucial in regenerative medicine, particularly in the development of autologous therapies. While progress has been made, challenges remain in understanding the characteristics of biomaterials and the molecular mechanisms regulating stem cell behavior.
APPLIED SCIENCES-BASEL
(2022)
Review
Endocrinology & Metabolism
Alberto Posabella, Andrea B. Alber, Hendrik J. Undeutsch, Raoul A. Droeser, Anthony N. Hollenberg, Laertis Ikonomou, Darrell N. Kotton
Summary: Stem cell-based therapies hold potential for reconstituting organ function, particularly in addressing hypothyroidism. Research has shown promise in engineering thyroid follicular epithelial cells to potentially cure the disease, but technical and biological challenges need to be overcome to achieve long-term cure through cell- and/or gene-based therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Naruphong Phunikom, Nittaya Boonmuen, Pakpoom Kheolamai, Kanoknetr Suksen, Sirikul Manochantr, Chairat Tantrawatpan, Duangrat Tantikanlayaporn
Summary: Andrographolide (AP) has been shown to promote proliferation, osteogenic differentiation, and bone formation of placenta-derived mesenchymal stem cells. It may be an effective novel agent for improving placenta-derived MSCs and stem cell-based therapy for bone regeneration. The compound enhances Wnt/beta-catenin signaling and osteoblast-specific gene expressions, promoting bone formation and increasing osteocalcin levels.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Veterinary Sciences
Emma Heyman, Marguerite Meeremans, Bert Devriendt, Maria Olenic, Koen Chiers, Catharina De Schauwer
Summary: This study presents a method to quantify the tri-lineage differentiation potential of mesenchymal stem cells (MSCs) using digital image analysis. By staining and calculating the area percentages, the differentiation potential of MSCs from different donors can be accurately evaluated. This straightforward method can be used for further optimization of regenerative medicine therapies.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Arsinoe C. Thomaidou, Maria Goulielmaki, Antonis Tsintarakis, Panagiotis Zoumpourlis, Marialena Toya, Ioannis Christodoulou, Vassilis Zoumpourlis
Summary: The human body contains multipotent cells known as mesenchymal stem cells (MSCs) that have the potential to self-renew and differentiate into various cell types. MSCs are attractive candidates for therapeutic applications due to their ability to migrate to inflammation sites and their secretion of factors involved in tissue regeneration and immune regulation. MSCs derived from fetal, perinatal, or neonatal tissues possess additional advantages, such as increased proliferation potential, responsiveness to environmental cues, and low immunogenicity. MicroRNAs (miRNAs) play a crucial role in regulating MSC differentiation, and the identification of relevant miRNAs and miRNA signatures can enhance the understanding of MSC biology and aid in the development of regenerative and therapeutic protocols. This review focuses on umbilical cord-derived MSCs (UCMSCs) and discusses their miRNA-guided differentiation and regulatory mechanisms, highlighting their potential applications in treating various diseases and injuries while minimizing adverse events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell & Tissue Engineering
Pedram Iranmanesh, Amirhossein Vedaei, Sadra Salehi-Mazandarani, Parvaneh Nikpour, Saber Khazaei, Abbasali Khademi, Kerstin M. M. Galler, Mohammad-Hossein Nekoofar, Paul M. H. Dummer
Summary: This systematic review investigated the mechanisms regulating the differentiation of hDP-MSCs and identified several miRNAs involved in this process. Bioinformatic analysis revealed target genes, signaling pathways, and gene ontologies associated with these miRNAs. The findings support the potential application of these specific miRNAs in regulating the directed differentiation of hDP-MSCs in regenerative therapies.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Bingren Tian, Jiayue Liu, Songlin Guo, Aiqin Li, Jian-Bo Wan
Summary: The role of regenerative medicine in clinical therapies is increasingly important. Mesenchymal stem cells (MSCs) have the ability to differentiate into various cells and have attracted great interest among researchers. Materials science provides natural extracellular matrices for MSCs and helps understand their differentiation mechanisms, maximizing the potential applications of MSCs. Pharmaceutical fields contribute to biomaterial research by developing macromolecule-based hydrogel nanoarchitectonics. Various biomaterials are used to prepare hydrogels with unique properties, providing a controlled microenvironment for MSC culture, laying the foundation for future regenerative medicine applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Kasra Moeinabadi-Bidgoli, Amirhesam Babajani, Ghasem Yazdanpanah, Behrouz Farhadihosseinabadi, Elham Jamshidi, Soheyl Bahrami, Hassan Niknejad
Summary: Cell-based therapy and stem cell-based regenerative medicine are new approaches for treating degenerative diseases, but face challenges in clinical practice. Preconditioning methods could improve the outcomes of stem cell therapy by enhancing cell resistance against the host environment and improving various biological aspects of cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell & Tissue Engineering
Junichi Matsuo, Naing Naing Mon, Daisuke Douchi, Akihiro Yamamura, Madhura Kulkarni, Dede Liana Heng, Sabirah Chen, Napat Nuttonmanit, Ying Li, Henry Yang, May Yin Lee, Wai Leong Tam, Motomi Osato, Linda Shyue Huey Chuang, Yoshiaki Ito
Summary: Researchers have identified an active element called eR1 that can mark mammary stem cells and found its activity in a small population of luminal epithelial cells in the mammary glands. They demonstrated that eR1+ luminal cells can generate the entire luminal lineage and milk-secreting alveoli, indicating that eR1 specifically marks lineage-restricted luminal stem cells.
Article
Chemistry, Medicinal
Nuzhat Parveen, Yan-Liang Lin, Md Imran Khan, Ruey-Hwang Chou, Chung-Ming Sun, Chin Yu
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Medicine, General & Internal
Kuang-Hsi Chang, Yi-Chao Hsu, Ing-Ming Chiu, Lih-Chyang Chen, Chih-Chao Hsu, Chang-Yin Lee, Hueng-Chuen Fan, Hsuan-Ju Chen, Ruey-Hwang Chou
Article
Multidisciplinary Sciences
Deepu Dowarha, Ruey-Hwang Chou, Chin Yu
Article
Oncology
Yi-Chung Chien, Jia-Ni Chen, Ya-Huey Chen, Ruey-Hwang Chou, Han-Chung Lee, Yung-Luen Yu
Article
Biochemistry & Molecular Biology
Revansiddha H. Katte, Ruey-Hwang Chou, Chin Yu
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Audiology & Speech-Language Pathology
Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin, Kuang-Hsi Chang, Min-Chih Li, Ruey-Hwang Chou, Mei-Yue Huang, Yen-Chung Chen, Chien-Yu Kao, Ching-Chang Cheng, Hung-Ching Lin, Yi-Chao Hsu
Summary: MSCs can be isolated from different tissue origins and have the potential to ameliorate ototoxicity-induced hearing loss. In this study, skin-derived MSCs were found to significantly reduce the hearing threshold of mice with cisplatin-induced hearing loss. Neuropathological gene analyses revealed the mechanisms through which SMSCs could alleviate cochlear damage and hearing loss induced by cisplatin.
Article
Biochemistry & Molecular Biology
Revansiddha H. Katte, Deepu Dowarha, Ruey-Hwang Chou, Chin Yu
Summary: Pentamidine disrupts the S100P-53 complex formation by targeting the shared binding site of S100P and p53, leading to re-activation of the p53-21 pathway and inhibition of cancer cell proliferation. This suggests a potential new avenue for cancer therapy targeting the S100P-p53 interaction.
Article
Biochemistry & Molecular Biology
Stella Chin-Shaw Tsai, Kuender D. Yang, Kuang-Hsi Chang, Frank Cheau-Feng Lin, Ruey-Hwang Chou, Min-Chih Li, Ching-Chang Cheng, Chien-Yu Kao, Chie-Pein Chen, Hung-Ching Lin, Yi-Chao Hsu
Summary: The study demonstrated that UCMSC exosomes have protective effects in treating ototoxicity-induced hearing loss by promoting tissue remodeling and repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chia-Hung Chen, Bo-Wei Wang, Yu-Chun Hsiao, Chun-Yi Wu, Fang-Ju Cheng, Te-Chun Hsia, Chih-Yi Chen, Yihua Wang, Zhang Weihua, Ruey-Hwang Chou, Chih-Hsin Tang, Yun-Ju Chen, Ya-Ling Wei, Jennifer L. Hsu, Chih-Yen Tu, Mien-Chie Hung, Wei-Chien Huang
Summary: Upregulation of active sodium/glucose co-transporter 1 (SGLT1) was found to confer the development of acquired EGFR TKI resistance and was correlated with poorer clinical outcomes in NSCLC patients. Blockade of SGLT1 overcame this resistance by reducing glucose uptake in NSCLC cells, suggesting a potential strategy to improve the therapeutic efficacy of EGFR TKIs in NSCLC patients.
Article
Environmental Sciences
Hung-Lin Chen, Ruihong Zhang, Stella Chin-Shaw Tsai, Ruey-Hwang Chou, Yi-Chao Hsu, Hueng-Chuen Fan, Chih-Hsin Muo, Chung Y. Hsu, Kuang-Hsi Chang
Summary: The study found that children and teenagers in Taiwan exposed to SO2, CO, and NO2 have an increased risk of developmental delay. The adjusted odds ratios for developmental delay in comparison among the tertiles with respect to SO2, CO, and NO2 exposures were 1.12, 1.21, and 1.40, respectively.
Article
Medicine, General & Internal
Ruey-Hwang Chou, Meng-Yin Yang, Yi-Ping Yang, Chun-An Yeh, Wei-Yi Lai, Tzu-Wei Lin, Yuan-Chi Teng, Shu-Chen Hsieh, Mei-Lang Kung, Hsien-Hsu Hsieh, Huey-Shan Hung
Summary: The development of dual functional nanomaterials, such as N-Epo-FePt nanoparticles, offers increased versatility for biological applications. These nanoparticles demonstrate enhanced biocompatibility and multiple fluorescent properties in mesenchymal stem cells, showing potential for diverse imaging and tracking applications.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Stella Chin-Shaw Tsai, Yi-Chao Hsu, Jung-Nien Lai, Ruey-Hwang Chou, Hueng-Chuen Fan, Frank Cheau-Feng Lin, Ruihong Zhang, Cheng-Li Lin, Kuang-Hsi Chang
Summary: This study revealed an increased risk of SSNHL in residents with long-term exposure to air pollution, especially in those exposed to higher concentrations of CO, NO, and NO2. Additionally, patients exposed to moderate and high levels of PM2.5 also showed a significant higher risk of developing SSNHL. Further experimental and clinical studies are needed to verify these findings.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Han-Jie Lin, Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin, Yi-Chao Hsu, Shih-Wei Chen, Ruey-Hwang Chou, Cheng-Li Lin, Chung Y. Hsu, Kuang-Hsi Chang
Summary: Residents in Taiwan with long-term exposure to higher levels of air pollutants had a greater risk of periodontitis, with various air pollutants being associated with the risk of periodontitis.
Article
Chemistry, Multidisciplinary
Nuzhat Parveen, Yan-Liang Lin, Ruey-Hwang Chou, Chung-Ming Sun, Chin Yu
Summary: The study focuses on the synthesis and applications of suramin derivatives, which show potential as novel therapeutic agents for their anti-proliferative activity via the inhibition of protein-protein interactions.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Nuzhat Parveen, Wei-Jung Chiu, Li-Ching Shen, Ruey-Hwang Chou, Chung-Ming Sun, Chin Yu
Summary: The S100A1 protein undergoes conformational changes upon binding to calcium ions, which allows it to interact with target proteins. The extracellular domain of the RAGE receptor consists of C1, C2, and V domains, with the V domain being the primary receptor for S100 proteins. The interaction between S100A1 and RAGE V domains leads to RAGE dimerization and initiates a signaling cascade that regulates cell proliferation, growth, and tumor formation. In this study, pentamidine analogs were used to inhibit the interaction between S100A1 and RAGE V domains.
