Generation of Human Alloantigen-Specific Regulatory T Cells under Good Manufacturing Practice-Compliant Conditions for Cell Therapy

Novel GMP-Compatible Protocol Employing an Allogeneic B Cell Bank for Clonal Expansion of Allospecific Natural Regulatory T Cells

(2014) S. Landwehr-Kenzel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Novel Immunosuppression Compounds and Experimental Therapies for Chronic Graft-Versus-Host Disease

(2013) Maria Michael et al.   ACTA HAEMATOLOGICA

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human regulatory T cells against minor histocompatibility antigens: ex vivo expansion for prevention of graft-versus-host disease

(2013) A. Veerapathran et al.   BLOOD

Third-party umbilical cord blood–derived regulatory T cells prevent xenogenic graft-versus-host disease

(2013) Simrit Parmar et al.   CYTOTHERAPY

In vivo activation of transferred regulatory T cells specific for third-party exogenous antigen controls GVH disease in mice

(2013) Gaëlle H. Martin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Role of Regulatory T Cells in the Biology of Graft Versus Host Disease

(2013) Amy J. Beres et al.   Frontiers in Immunology

Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion

(2012) Y. C. Kim et al.   BLOOD

Depletion of T regulatory cells through selection of CD127-positive cells results in a population enriched in memory T cells: implications for anti-tumor cell therapy

(2012) S. Touil et al.   HAEMATOLOGICA

A Converse 4-1BB and CD40 Ligand Expression Pattern Delineates Activated Regulatory T Cells (Treg) and Conventional T Cells Enabling Direct Isolation of Alloantigen-Reactive Natural Foxp3+ Treg

(2012) A. Schoenbrunn et al.   JOURNAL OF IMMUNOLOGY

Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly

(2011) A. Veerapathran et al.   BLOOD

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Isolation strategies of regulatory T cells for clinical trials: Phenotype, function, stability, and expansion capacity

(2011) Sya N. Ukena et al.   EXPERIMENTAL HEMATOLOGY

Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets

(2011) Patrick J. Schuler et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A role for interleukin-2 trans-presentation in dendritic cell–mediated T cell activation in humans, as revealed by daclizumab therapy

(2011) Simone C Wuest et al.   NATURE MEDICINE

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

(2010) Derese Getnet et al.   MOLECULAR IMMUNOLOGY

CD4+CD25+ Regulatory T Cell Depletion Improves the Graft-Versus-Tumor Effect of Donor Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation

(2010) S. Maury et al.   Science Translational Medicine

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

(2009) D. Q. Tran et al.   BLOOD

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

(2009) G. Wieczorek et al.   CANCER RESEARCH

The Tregs' world according to GARP

(2009) Manuela Battaglia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

La voie IL-2/IL-2R chez la cellule dendritique module à la fois leur synthèse de cytokines et leur capacité à activer des lymphocytes T CD4+ allogéniques

(2009) K. Mnasria et al.   PATHOLOGIE BIOLOGIE

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Activated T cells complicate the identification of regulatory T cells in rheumatoid arthritis

(2008) Nicolaas E. Aerts et al.   CELLULAR IMMUNOLOGY

Regulatory T cells as therapeutic cells

(2008) Pervinder Sagoo et al.   Current Opinion in Organ Transplantation

Ex vivo expansion of CD4+CD25+T regulatory cells for immunosuppressive therapy

(2008) Piotr Trzonkowski et al.   CYTOMETRY PART A

Role of TGF-β in the Induction of Foxp3 Expression and T Regulatory Cell Function

(2008) Ethan M. Shevach et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Clinical-grade preparation of human natural regulatory T-cells encoding the thymidine kinase suicide gene as a safety gene

(2008) Maude Guillot-Delost et al.   JOURNAL OF GENE MEDICINE

The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells

(2008) Thomas Y. Wuest et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4posCD25high T Cells for Immunotherapy

(2008) Jorieke H. Peters et al.   PLoS One