Article
Biochemistry & Molecular Biology
Yurong Fu, Yongcheng Jin, Yue Tian, Hao Yu, Ruqi Wang, Huiyu Qi, Bo Feng, Jing Zhang
Summary: The synergistic effect of ZEA and LPS aggravates cytotoxicity by increasing the accumulation of ROS and MDA, decreasing MMP and SOD levels, and reducing GSH levels. Additionally, ZEA and LPS promote cell apoptosis by activating ER stress and suppressing anti-apoptotic proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Jun Bai, Yusong Zhou, Xin Luo, Jia Hai, Xuemeng Si, Jun Li, Huiyang Fu, Zhaolai Dai, Ying Yang, Zhenlong Wu
Summary: This review summarizes the characteristics, metabolism, toxicity, and deleterious effects of Zearalenone (ZEA) exposure in various tissues of animals. The article highlights the involvement of stress response signaling in ZEA toxicity and discusses potential therapeutic options for reducing the harmful effects of ZEA in animals.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Agriculture, Dairy & Animal Science
Xiaoya Li, Huali Chen, Zelin Zhang, Jiaxin Duan, Rongmao Hua, Xiaodi Li, Li Yang, Jianyong Cheng, Qingwang Li
Summary: This study investigated the therapeutic effect of isorhamnetin on ZEA-induced damage in porcine ovarian granulosa cells and elucidated its molecular mechanism. The results showed that isorhamnetin protected ovarian granulosa cells from ZEA-induced damage, promoting proliferation and alleviating apoptosis, endoplasmic reticulum stress, oxidative stress, and steroidogenesis disorder.
Article
Environmental Sciences
Jicang Wang, Lulu Ding, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Hongwei Wang, Cai Zhang, Zijun Yang, Zongping Liu
Summary: This study aimed to determine the protective effect of quercetin (Que) on cadmium (Cd)-induced hepatotoxicity. Through in vivo and in vitro experiments using rat models, the researchers found that Cd caused liver injury and cell apoptosis, and activated endoplasmic reticulum stress (ERS) signaling pathways. However, Que was able to improve hepatocyte vitality, reduce liver damage and oxidative stress caused by Cd.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Agriculture, Dairy & Animal Science
Jun Bai, Jun Li, Ning Liu, Hai Jia, Xuemeng Si, Yusong Zhou, Zhian Zhai, Ying Yang, Fazheng Ren, Zhenlong Wu
Summary: This study investigated the toxicological effect and mechanism of Zearalenone (ZEA) exposure on reproduction in pigs during early stages of pregnancy. It was found that ZEA can cause cell cycle arrest, apoptosis, endoplasmic reticulum (ER) stress, and autophagy in trophoblast ectoderm cells. Furthermore, inhibiting ER stress can reduce cell death, suggesting a critical role of ER stress in the activation of autophagy.
Article
Agriculture, Dairy & Animal Science
Weihan Yang, Runfeng Liu, Qinqiang Sun, Xingchen Huang, Junjun Zhang, Liangfeng Huang, Pengfei Zhang, Ming Zhang, Qiang Fu
Summary: This study found that quercetin could attenuate the effects of endoplasmic reticulum stress on granulosa cells by the PERK/CHOP signaling pathway, providing a novel strategy for inhibiting the apoptosis of granulosa cells.
Review
Chemistry, Medicinal
Farhad Eisvand, Amir Tajbakhsh, Veronique Seidel, Mohammad Reza Zirak, Jamshid Tabeshpour, Abolfazl Shakeri
Summary: Endoplasmic reticulum (ER) stress is implicated in many diseases, making modulation of ER stress pathways an attractive therapeutic target. Quercetin, a plant-derived flavonoid, has various beneficial effects and can be utilized with nanotechnology to enhance its activity in combating ER stress-related diseases.
PHYTOTHERAPY RESEARCH
(2022)
Review
Medicine, Research & Experimental
Yuxin Du, Laurie J. Demillard, Jun Ren
Summary: Cerebrovascular diseases such as stroke can lead to cardiac complications through mechanisms such as catecholamine surges, which increase the risk of heart damage.
Article
Food Science & Technology
Yurong Fu, Yongcheng Jin, Anshan Shan, Jing Zhang, Hongyu Tang, Jinglin Shen, Changhai Zhou, Hao Yu, Hengtong Fang, Yun Zhao, Junxiong Wang, Yue Tian
Summary: The study showed that PD can effectively alleviate ZEA-induced damage on bovine mammary epithelial cells by reducing oxidative damage and ER stress, thus reducing cell apoptosis.
Article
Marine & Freshwater Biology
Wei Hu, Qing-Ling Zhu, Jia-Lang Zheng, Zheng-Yong Wen
Summary: Exposure to cadmium led to growth inhibition, increased cadmium accumulation, oxidative stress, and other negative effects in fish. However, fish exhibited compensatory adaptive responses to resist cadmium toxicity. Genes involved in metabolic pathways were dysregulated by cadmium, potentially contributing to the toxicity.
AQUATIC TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanyan Yi, Shuangxiu Wan, Shaoyu Wang, Ajab Khan, Jianhua Guo, Xiaozhong Zheng, Hongquan Li, Na Sun
Summary: The study demonstrated that Scutellarin (Scu) could significantly alleviate Zearalenone (ZEA)-induced damage in ovarian granulosa cells (GCs) through multiple mechanisms, inhibiting apoptosis and potentially serving as a therapeutic drug to treat reproductive toxicity caused by ZEA exposure in animal feeds.
Article
Environmental Sciences
Qiaoni Hu, Jifang Zheng, Xiao Na Xu, Chaohao Gu, Wanting Li
Summary: Uranium contamination induces excessive intracellular reactive oxygen species (ROS) generation, which is considered as a possible mediator of kidney tubular cells injury and nephrotoxicity. This study found that U exposure triggers endoplasmic reticulum stress, apoptosis, and down-regulation of PI3K/AKT/mTOR signaling. Administration of antioxidant N-acetylcysteine (NAC) effectively blocks ROS generation, ER stress, and apoptosis, and reverses the down-regulation of phosphorylated PI3K induced by U exposure.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Engineering, Environmental
Huanliang Liu, Wenqing Lai, Xiaohua Liu, Honglian Yang, Yanjun Fang, Lei Tian, Kang Li, Huipeng Nie, Wei Zhang, Yue Shi, Liping Bian, Susu Ding, Jun Yan, Bencheng Lin, Zhuge Xi
Summary: The research investigated the mechanism of hepatotoxicity and apoptosis caused by Nano-CuO through oxidative stress and ER-stress. Both in vivo and in vitro experiments confirmed that Nano-CuO induced oxidative stress, leading to ER-stress pathway activation and subsequently cell death.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Wenrong Feng, Shengyan Su, Changyou Song, Fan Yu, Jun Zhou, Jianlin Li, Rui Jia, Pao Xu, Yongkai Tang
Summary: High concentrations of copper pose a threat to aquatic animals, but the response mechanisms of crustaceans to Cu2+ exposure are not well understood. This study investigated the physiological and molecular changes in Chinese mitten crabs after Cu2+ exposure. The results showed that Cu2+ exposure decreased antioxidative capacity and promoted lipid peroxidation in different tissues. It also induced apoptosis and autophagy, and triggered an immune response. The toxicity of Cu2+ may be associated with the activation of ERK, AMPK, and TLR2-MyD88-NF-kappa B pathways.
Article
Environmental Sciences
Fu Cheng Yao, Yue Gu, Tian Jiang, Peng Fei Wang, Fei Biao Song, Zhi Zhou, Jun Long Sun, Jian Luo
Summary: Microplastics pollution is prevalent in coastal areas, posing a potential threat to marine organisms. In this study, the impact of polystyrene microplastics (PS-MPs) on Golden Pompano was investigated. The results showed that exposure to high concentrations of PS-MPs led to impaired growth, histopathological changes in the liver, oxidative stress, endoplasmic reticulum stress (ERS), apoptosis, metabolic alterations, and immune disturbance in the fish. These findings highlight the role of ERS in microplastics toxicology and reveal the adverse effects of microplastics on Golden Pompano.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandre Prola, Zuzana Nichtova, Julie Pires Da Silva, Jerome Piquereau, Kevin Monceaux, Arnaud Guilbert, Melanie Gressette, Renee Ventura-Clapier, Anne Garnier, Ivan Zahradnik, Marta Novotova, Christophe Lemaire
CARDIOVASCULAR RESEARCH
(2019)
Article
Endocrinology & Metabolism
Marko Ljubkovic, Melanie Gressette, Cristijan Bulat, Marija Cavar, Darija Bakovic, Damir Fabijanic, Ivica Grkovic, Christophe Lemaire, Jasna Marinovic
Article
Cell Biology
Julie Pires Da Silva, Kevin Monceaux, Arnaud Guilbert, Melanie Gressette, Jerome Piquereau, Marta Novotova, Renee Ventura-Clapier, Anne Garnier, Christophe Lemaire
Article
Endocrinology & Metabolism
Laure Delavallee, Navrita Mathiah, Lauriane Cabon, Aurelien Mazeraud, Marie-Noelle Brunelle-Navas, Leticia K. Lerner, Mariana Tannoury, Alexandre Prola, Raquel Moreno-Loshuertos, Mathieu Baritaud, Laura Vela, Kevin Garbin, Delphine Garnier, Christophe Lemaire, Francina Langa-Vives, Martine Cohen-Salmon, Patricio Fernandez-Silva, Fabrice Chretien, Isabelle Migeotte, Santos A. Susin
MOLECULAR METABOLISM
(2020)
Article
Cell Biology
Jennyfer Levoux, Alexandre Prola, Peggy Lafuste, Marianne Gervais, Nathalie Chevallier, Zeynab Koumaiha, Kaouthar Kefi, Laura Braud, Alain Schmitt, Azzedine Yacia, Aurelie Schirmann, Barbara Hersant, Mounia Sid-Ahmed, Sabrina Ben Larbi, Katerina Komrskova, Jakub Rohlena, Frederic Relaix, Jiri Neuzil, Anne-Marie Rodriguez
Summary: Platelets enhance the therapeutic potential of MSCs by transferring mitochondria and promoting pro-angiogenic activity. Activation of the de novo fatty acid synthesis pathway is required for increased secretion of pro-angiogenic factors by platelet-preconditioned MSCs. Testing platelet mitochondria quality before clinical use is crucial for optimizing their effects.
Article
Multidisciplinary Sciences
Alexandre Prola, Jordan Blondelle, Aymeline Vandestienne, Jerome Piquereau, Raphael G. P. Denis, Stephane Guyot, Hadrien Chauvin, Arnaud Mourier, Marie Maurer, Celine Henry, Nahed Khadhraoui, Cindy Gallerne, Thibaut Molinie, Guillaume Courtin, Laurent Guillaud, Melanie Gressette, Audrey Solgadi, Florent Dumont, Julien Castel, Julien Ternacle, Jean Demarquoy, Alexandra Malgoyre, Nathalie Koulmann, Genevieve Derumeaux, Marie-France Giraud, Frederic Joubert, Vladimir Veksler, Serge Luquet, Frederic Relaix, Laurent Tiret, Fanny Pilot-Storck
Summary: Mice deficient for a muscle-specific enzyme of very-long-chain fatty acid synthesis displayed increased basal energy expenditure and protection against high-fat diet-induced obesity. Muscle-specific modulation of the very-long-chain fatty acid pathway was associated with a reduced content of inner mitochondrial membrane phospholipid cardiolipin and a blunted coupling efficiency between the respiratory chain and ATP synthase, which was restored by cardiolipin enrichment. Selective increase of lipid oxidative capacities in skeletal muscle, through the cardiolipin-dependent lowering of mitochondrial ATP production, provides an effective option against obesity at the whole-body level.
Correction
Cell Biology
Jennyfer Levoux, Alexandre Prola, Peggy Lafuste, Marianne Gervais, Nathalie Chevallier, Zeynab Koumaiha, Kaouthar Kefi, Laura Braud, Alain Schmitt, Azzedine Yacia, Barbara Hersant, Mounia Sid-Ahmed, Sabrina Ben Larbi, Katerina Komrskova, Jakub Rohlena, Frederic Relaix, Jiri Neuzil, Anne-Marie Rodriguez
Review
Multidisciplinary Sciences
F. Relaix, M. Bencze, M. J. Borok, A. Der Vartanian, F. Gattazzo, D. Mademtzoglou, S. Perez-Diaz, A. Prola, P. C. Reyes-Fernandez, A. Rotini, V Taglietti
Summary: Skeletal muscle possesses remarkable regenerative capabilities, mainly attributed to its resident muscle stem cells. Recent technological advancements have provided mechanistic insights into MuSC biology, emphasizing their role in regeneration, muscle disorders, and aging. The complex regulation of MuSCs by their niche and the understanding of their metabolic role impact the broader understanding of stem cells and their therapeutic applications in regenerative medicine.
NATURE COMMUNICATIONS
(2021)
Review
Biology
Alexandre Prola, Fanny Pilot-Storck
Summary: Understanding the impact of obesity on cardiolipin, a specific phospholipid in mitochondria, can provide insights into the mechanisms of obesity and potentially offer strategies for managing it. This review gathers evidence showing the alterations of cardiolipin in obesity and its association with mitochondrial dysfunction. Different approaches to correct these alterations can improve cellular metabolism and mitigate the consequences of obesity. Modulation of cardiolipin may serve as a lever to increase mitochondrial energy expenditure and induce weight loss. Cardiolipin may prove to be a possible weapon in the fight against obesity.
Article
Biochemistry & Molecular Biology
Etimad Huwait, Nouf Al-Gharawi, Maryam A. Al-Ghamdi, Mamdooh Gari, Alexandre Prola, Peter Natesan Pushparaj, Gauthaman Kalamegam
Summary: This study evaluated the effects of Thymoquinone (TQ) on key pathogenic stages of atherosclerosis and identified potential molecular targets and signaling mechanisms using in-vitro experiments and in-silico analysis. The results suggest that TQ has anti-inflammatory effects and may be a potential nutraceutical candidate for the prevention and treatment of atherosclerosis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biology
Alexandre Prola, Aymeline Vandestienne, Nabil Baroudi, Frederic Joubert, Laurent Tiret, Fanny Pilot-Storck
Summary: Efficient ATP production in mitochondria relies on the specific phospholipid composition of the inner mitochondrial membrane. Studying the contribution of specific phospholipids to mitochondrial functions is often hindered by the interconnection of phospholipid synthesis pathways, but a protocol for enriching mitochondrial membranes with specific phospholipids and quantifying the enrichment through a fluorescence-based method can help overcome this obstacle.
Article
Sport Sciences
Alexandra Malgoyre, Alexandre Prola, Adelie Meunier, Rachel Chapot, Bernard Serrurier, Nathalie Koulmann, Xavier Bigard, Herve Sanchez
Summary: The study shows that training in high-altitude environments can enhance maximal aerobic velocity in endurance athletes, and living and training in hypoxic conditions can increase endurance time. However, this combination also decreases mitochondrial mass and oxidative capacity.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2021)
Article
Chemistry, Medicinal
Sanaa Almowallad, Etimad Huwait, Rehab Al-Massabi, Salma Saddeek, Kalamegam Gauthaman, Alexandre Prola
Article
Environmental Sciences
Yosra Ben Othmene, Kevin Monceaux, Ahmed Karoui, Intidhar Ben Salem, Anissa Belhadef, Salwa Abid-Essefi, Christophe Lemaire
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)