Tolerization against atherosclerosis using heat shock protein 60

Mycobacterial heat shock protein 65 (mbHSP65)-induced atherosclerosis: Preventive oral tolerization and definition of atheroprotective and atherogenic mbHSP65 peptides

(2015) Cecilia Grundtman et al.   ATHEROSCLEROSIS

The role of heat shock proteins in atherosclerosis

(2014) Georg Wick et al.   Nature Reviews Cardiology

Activation of inflammatory cells and cytokines by peptide epitopes in vitro: a simple in-vitro screening assay for prioritizing them for in-vivo studies

(2013) Lakshmi A. Mundkur et al.   INFLAMMATION RESEARCH

Mucosal Tolerance to a Combination of ApoB and HSP60 Peptides Controls Plaque Progression and Stabilizes Vulnerable Plaque in Apobtm2SgyLdlrtm1Her/J Mice

(2013) Lakshmi Mundkur et al.   PLoS One

Impact of multiple antigenic epitopes from ApoB100, hHSP60 and Chlamydophila pneumoniae on atherosclerotic lesion development in Apobtm2SgyLdlrtm1Her J mice

(2012) Xinjie Lu et al.   ATHEROSCLEROSIS

Epitope-specific immune tolerization ameliorates experimental autoimmune encephalomyelitis

(2012) Rosario Billetta et al.   CLINICAL IMMUNOLOGY

Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity

(2012) Yasuaki Tamura et al.   Immunotherapy

Autoreactive HSP60 epitope-specific T-cells in early human atherosclerotic lesions

(2012) Giovanni Almanzar et al.   JOURNAL OF AUTOIMMUNITY

Establishment of nasal tolerance to heat shock protein-60 alleviates atherosclerosis by inducing TGF-β-dependent regulatory T cells

(2012) Haiyu Li et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Toll-like receptor blocker slows beta cell death in type 1 diabetes

(2012) Susan Aldridge   NATURE BIOTECHNOLOGY

Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis

(2012) M. J. C. van Herwijnen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Heat Shock Proteins in Antigen Cross Presentation

(2012) Ayesha Murshid et al.   Frontiers in Immunology

Heat Shock Protein 60 and Immune Inflammatory Responses in Atherosclerosis

(2011) Cecilia Grundtman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The autoimmune concept of atherosclerosis

(2011) Cecilia Grundtman et al.   CURRENT OPINION IN LIPIDOLOGY

A novel atherogenic epitope from Mycobacterium tuberculosis heat shock protein 65 enhances atherosclerosis in rabbit and LDL receptor-deficient mice

(2011) Yu Zhang et al.   HEART AND VESSELS

Subcutaneous immunization with heat shock protein-65 reduces atherosclerosis in Apoe−/− mice

(2011) Roland Klingenberg et al.   IMMUNOBIOLOGY

Bacterial Heat Shock Protein 60, GroEL, Can Induce the Conversion of Naïve T Cells into a CD4+ CD25+ Foxp3-Expressing Phenotype

(2011) Ryuji Ohue et al.   Journal of Innate Immunity

Oral administration of Lactococcus lactis delivered heat shock protein 65 attenuates atherosclerosis in low-density lipoprotein receptor-deficient mice

(2011) Hou Jing et al.   VACCINE

Immunization with a combination of ApoB and HSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice

(2010) Xinjie Lu et al.   ATHEROSCLEROSIS

Deficiency of Antigen-Presenting Cell Invariant Chain Reduces Atherosclerosis in Mice

(2010) Jiusong Sun et al.   CIRCULATION

Immunological efficacy of heat shock protein 60 peptide DiaPep277TM therapy in clinical type I diabetes

(2010) V. A. L. Huurman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Resident intimal dendritic cells and the initiation of atherosclerosis

(2010) Myron I Cybulsky et al.   CURRENT OPINION IN LIPIDOLOGY

Dendritic cells and their role in atherogenesis

(2010) Yuri V Bobryshev   LABORATORY INVESTIGATION

Prolonged Survival of Allografts Induced by Mycobacterial Hsp70 Is Dependent on CD4+CD25+ Regulatory T Cells

(2010) Thiago J. Borges et al.   PLoS One

Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial

(2009) Eva C. Koffeman et al.   ARTHRITIS AND RHEUMATISM

Atheroprotective Effects of Alum Are Associated With Capture of Oxidized LDL Antigens and Activation of Regulatory T Cells

(2009) Maria Wigren et al.   CIRCULATION RESEARCH

Nasal immunization with heat shock protein 65 attenuates atherosclerosis and reduces serum lipids in cholesterol-fed wild-type rabbits probably through different mechanisms

(2009) Qiyan Xiong et al.   IMMUNOLOGY LETTERS

IL-10 Is Critically Involved in Mycobacterial HSP70 Induced Suppression of Proteoglycan-Induced Arthritis

(2009) Lotte Wieten et al.   PLoS One

Cardiovascular Risk Factors and Atherosclerosis in Young Women

(2009) Michael Knoflach et al.   STROKE

Elevated Heat Shock Protein 60 Levels Are Associated With Higher Risk of Coronary Heart Disease in Chinese

(2008) Xiaomin Zhang et al.   CIRCULATION

CX 3 CR1 Deficiency Impairs Dendritic Cell Accumulation in Arterial Intima and Reduces Atherosclerotic Burden

(2007) Peng Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

T-cells from advanced atherosclerotic lesions recognize hHSP60 and have a restricted T-cell receptor repertoire

(2007) Andrea Rossmann et al.   EXPERIMENTAL GERONTOLOGY