Article
Pharmacology & Pharmacy
Mohammad Foad Abazari, Sepehr Torabinejad, Shohreh Zare Karizi, Hadi Samadian, Sahar Jalili-ghelichi, Mehdi Norouzi, Hassan Askari, Vahdat Poortahmasebi, Seyedeh Elnaz Enderami, Fatemeh Soleimanifar
Summary: This study demonstrates the high osteo-supportive capacity of a modified nanofibrous scaffold using human placental extract. It provides a potential candidate for bone tissue engineering.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Zahra Moazzami Goudarzi, Tayebeh Behzad, Laleh Ghasemi-Mobarakeh, Mahshid Kharaziha
Summary: The study demonstrated that the addition of ACNF significantly improved the tensile strength of PCL/Gel scaffold, while reducing the degradation rate. Incorporation of ACNF showed no cytotoxic effects and promoted cell proliferation.
Article
Materials Science, Multidisciplinary
Yi-Hsun Yu, Chen-Hung Lee, Yung-Heng Hsu, Ying-Chao Chou, Ping-Chun Yu, Shih-Jung Liu
Summary: The study prepared an implantable material containing celecoxib, collagen, bupivacaine, and PLGA through electrospinning. The drug-eluting nanofibers showed smaller fiber diameters and higher hydrophilicity. In vitro and in vivo experiments demonstrated sustained release of celecoxib for at least 30 and 28 days, respectively. Repairing ruptured Achilles tendons using the CCBP combination nanofibers improved maximum load-to-failure and growth factor expression.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Silvia Pisani, Stefania Croce, Simone Mauramati, Marta Marmonti, Lorenzo Cobianchi, Irene Herman, Rossella Dorati, Maria Antonietta Avanzini, Ida Genta, Marco Benazzo, Bice Conti
Summary: The use of a polymeric full-thickness scaffold engineered with mesenchymal stem cells (MSCs) shows promise in promoting esophageal regeneration and avoiding the need for autologous conduits.
Article
Pharmacology & Pharmacy
Eleonora Bianchi, Angela Faccendini, Elena Del Favero, Caterina Ricci, Laura Caliogna, Barbara Vigani, Francesco Claudio Pavesi, Cesare Perotti, Rui M. A. Domingues, Manuela E. Gomes, Silvia Rossi, Giuseppina Sandri
Summary: This study develops a tubular scaffold based on pullulan and chitosan for enhancing enthesis repair. The scaffold has a gradient of nanofiber arrangement and hydroxyapatite nanoparticles, with one part resembling bone tissue and the other part having aligned fibers. Human adipose stem cells are able to grow and differentiate on the scaffold, expressing tendon-specific ECM production or bone tissue in different regions. Chondroitin sulfate promotes cell adhesion and proliferation on the scaffold surface.
Article
Biochemistry & Molecular Biology
Abolfazl Mozaffari, Mazeyar Parvinzadeh Gashti
Summary: In this study, tannic acid-crosslinked gelatin nanofibers were fabricated by electrospinning and treated with atmospheric air plasma to enhance their bio-functionality. The results showed that atmospheric air plasma treatment not only improved the hydrophilicity of the nanofibers but also enhanced their bio-functionality against human skin fibroblast cells. Therefore, atmospheric air plasma pre-treatment is recommended for the surface functionalization of gelatin nanofibers in skin tissue engineering applications.
Review
Materials Science, Multidisciplinary
Xiaoyun Xu, Yifan Si, Yi Zhao, Qinfei Ke, Jinlian Hu
Summary: The repair of tendon to bone junction (TBJ) is a major challenge in tissue engineering. This article reviews the fabrication methods, properties, and technologies of electrospun biomedical scaffolds used for TBJ repair. It also discusses how traditional textile technology can be utilized to improve the mechanical properties of electrospun scaffolds.
ADVANCED FIBER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chih-Hao Chen, Dai-Ling Li, Andy Deng-Chi Chuang, Banendu Sunder Dash, Jyh-Ping Chen
Summary: The study prepared core-sheath nanofibers with different structures for tendon tissue engineering, and demonstrated that the combined effects of aligned fibers and PRP could enhance cell proliferation rates and gene expression in tenocytes. Additionally, dynamic cell culture in a bioreactor with cyclic tension stimulation could accelerate tendon maturation in vitro, leading to improved cell proliferation rates and maintenance of tenogenic phenotype compared to static culture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Food Science & Technology
Mohammadreza Rostami, Hanieh Kolahi Azar, Mojdeh Salehi, Shabnam Abedin Dargoush, Hosein Rostamani, Gholamreza Jahed-Khaniki, Mahsa Alikord, Reza Aghabeigi, Azam Ahmadi, Nima Beheshtizadeh, Thomas J. Webster, Nima Rezaei
Summary: Encapsulating curcumin in various nanocarriers has shown potential for industrial and biomedical applications. Nanofibers containing curcumin offer advantages such as excellent surface-to-volume ratios, controlled release, and diverse properties for different applications. However, the effectiveness of electrospun fibers may be affected by machine- and material-dependent parameters. This review explores recent research on nanofibers containing curcumin and their applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Muheeb Rafiq, Sami-ullah Rather, Taha Umair Wani, Anjum Hamid Rather, Rumysa Saleem Khan, Anees Ellahi Khan, Ibtisam Hamid, Haseeb A. Khan, Abdullah S. Alhomida, Faheem A. Sheikh
Summary: After the discovery of MXene, a new class of 2D material, researchers have found a new scope for their research. MXenes have remarkable physical, chemical, and biological properties, making them useful in various research disciplines. They have been applied in biosensors, bioimaging, tissue engineering, drug delivery systems, and more. MXenes can be functionalized with different atoms/molecules, making them diverse materials. Their potential in nanofibers is even greater than expected.
CHINESE CHEMICAL LETTERS
(2023)
Review
Instruments & Instrumentation
Divya Pamu, Vyshnavi Tallapaneni, Veera Venkata Satyanarayana Reddy Karri, Sachin Kumar Singh
Summary: Diabetes mellitus is a complex disease affecting millions worldwide, with diabetic wound being a common complication. Early detection, debridement, offloading, and infection control are crucial for diabetic wound treatment. Nanofiber dressings are considered a promising innovative approach, offering high moisture absorption, oxygen exchange rate, and antibacterial properties.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Mafalda S. Santos, Marta S. Carvalho, Joao C. Silva
Summary: Periodontitis is an inflammatory infection caused by bacterial plaque accumulation. Current treatments lack bioactive signals for tissue repair and regeneration. Electrospun nanofibers have shown promising results for periodontal regeneration due to their ability to mimic the natural extracellular matrix. This review provides an overview of the current state of electrospun nanofibrous scaffolds in periodontal regeneration strategies.
Review
Biotechnology & Applied Microbiology
James A. Smith, Elisa Mele
Summary: Electrospinning technology produces fibers at micro- to nanometer scale, while AM technology offers geometrical freedom to build complex components quickly. Combining these two technologies can result in scaffolds that better match the natural architecture of human tissues.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Polymer Science
Norul Ashikin Norzain, Zhi-Wei Yu, Wei-Chih Lin, Hsing-Hao Su
Summary: This study describes the fabrication of a structural scaffold with a combination of randomly oriented nanofibers and triangular prism patterns, showing improved fibroblast cell proliferation and orientation compared to flat random nanofibers. The scaffold accelerated wound closure in vivo and exhibited advanced healing properties.
Review
Chemistry, Multidisciplinary
Quynh N. Nguyen, Chenxiao Wang, Yuxin Shang, Annemieke Janssen, Younan Xia
Summary: Nanocrystals offer a unique platform for enhancing the performance of solid materials in various applications. Asymmetrical growth and symmetry breaking provide a powerful approach to enrich metal nanocrystals with new shapes, complex morphologies, and unprecedented properties. This Review summarizes recent progress in understanding and controlling asymmetrical growth and symmetry breaking in the colloidal synthesis of noble-metal nanocrystals. It discusses methods for generating seeds with diverse symmetry and achieving asymmetrical growth, showcases symmetry-broken nanocrystals, and highlights their growth mechanisms, properties, and applications. Future directions in developing this class of nanomaterials are also discussed.
Review
Chemistry, Multidisciplinary
Haoyan Cheng, Chenxiao Wang, Dong Qin, Younan Xia
Summary: Galvanic replacement synthesis involves the oxidation and dissolution of atoms from a substrate while reducing and depositing a salt precursor with a higher reduction potential on the substrate. Micro/nanostructured materials can be mixed with the salt precursor in a solution phase, increasing the surface area and allowing for controlled growth patterns of the deposited material. This synthesis method has been successfully applied to various substrates, resulting in diverse nanomaterials with controllable compositions and morphologies.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Kei Kwan Li, Chia-Ying Wu, Tung-Han Yang, Dong Qin, Younan Xia
Summary: Surface ligands are crucial for the synthesis of noble-metal nanocrystals with precise sizes and shapes. They play a dual role of determining nanocrystals' shapes and stabilizing them against aggregation. Different ligands can be used to control the growth of nanocrystals and create complex structures. Surface ligands also enable various applications in sensing, imaging, nanomedicine, and self-assembly. However, quantitatively determining the coverage density of ligand molecules and replacing or removing them without compromising the nanocrystals' structure remain challenging.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Editorial Material
Chemistry, Multidisciplinary
Younan Xia, Qian Chen, Uri Banin
Article
Chemistry, Physical
Veronica Pawlik, Shan Zhou, Siyu Zhou, Dong Qin, Younan Xia
Summary: Silver has been used throughout human history for various purposes and has recently gained significance in nanomaterial development. This article provides a historical account of the colloidal synthesis of silver nanocubes and explores their major applications. The accidental synthesis of silver nanocubes initiated investigations into the individual components of the protocol, leading to a better understanding of the mechanistic puzzle. The article also discusses the obstacles faced in the original method and the development of applications based on the properties of silver nanocubes.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Jacob Jeskey, Yidan Chen, Sujin Kim, Younan Xia
Summary: We developed a simple method for synthesizing N-doped carbon nanospheres with uniform and tunable sizes. The synthesis involves the incorporation of EDTA into the emulsion droplets of phenolic resin oligomers, providing surface charges to prevent the coalescing of the droplets. The resulting N-doped carbon nanospheres have highly uniform sizes and shapes, and can be crystallized into opaline structures for fabricating opaline lattices with brilliant colors. The EDTA also promotes the formation of graphitic-N, making the nanospheres highly active electrocatalysts.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tian Lv, Maochang Liu, Siyu Zhou, Younan Xia
Summary: This article presents a systematic study on the oxidative etching and regrowth behaviors of Pd nanocrystals of different shapes and twin structures. The etching process removes Pd atoms preferentially from the corners, while the regrowth process deposits newly formed Pd atoms on the {100} facets and twin boundaries. The shape and size of the nanocrystals can be controlled by adjusting the concentration of HCl in the reaction solution.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Hansong Yu, Yong Ding, Peng Wang, Quynh Nguyen, Younan Xia, Dong Qin
Summary: Noble-metal nanoboxes, such as Ag-Ru core-shell nanocubes and Ru nanoboxes, were synthesized and evaluated for their catalytic activity. The nanoboxes exhibited excellent performance in a model hydrogenation reaction.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyu Qiu, Veronica Pawlik, Shan Zhou, Jing Tao, Younan Xia
Summary: Two growth patterns of Au atoms on penta-twinned Pd decahedra were reported, resulting in asymmetric Pd-Au Janus icosahedra and anisotropic Pd@Au core-shell starfishes, respectively. The injection rate of Au(III) ions determined the growth pattern, with slow injection leading to asymmetric growth and fast injection resulting in symmetric growth. Mechanistic analysis revealed the formation process of the two heterostructures.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Veronica Pawlik, Shan Zhou, Dong Qin, Younan Xia
Summary: This article summarizes the significant progress made in the synthesis, structure-property relationship, and application of plasmonic nanomaterials. It provides specific examples of demonstrations and developments, and discusses the challenges and opportunities in pushing plasmonic nanomaterials to the next level of success.
Article
Chemistry, Physical
Chenxiao Wang, Ying Lyu, Younan Xia
Summary: We report a simple method to synthesize Pd@Rh core-shell nanocubes with ultrathin Rh shell and well-defined {100} facets for the production of Rh cubic nanocages. The growth of Rh overlayers on Pd cubic seeds can be controlled by adjusting the deposition and diffusion rates of Rh adatoms. The resulting Rh nanocages exhibit enhanced shape stability and ultrathin walls with preserved {100} facets, which has not been reported previously.
Article
Cell & Tissue Engineering
Elda A. Trevino, Jimmy Shah, Joseph J. Pearson, Manu O. Platt, Younan Xia, Johnna S. Temenoff
Summary: This study successfully developed a novel microfluidic device to fabricate uniform, hydrolytically degradable microparticles loaded with the cathepsin inhibitor E-64. Commercially available fluorogenic assays were validated to quantify the release and bioactivity of the inhibitor from the biomaterial carriers. These technologies make significant contributions towards local delivery of cathepsin inhibitors.
TISSUE ENGINEERING PART C-METHODS
(2023)
Article
Chemistry, Multidisciplinary
Jacob Jeskey, Yong Ding, Yidan Chen, Zachary D. Hood, George E. Sterbinsky, Mietek Jaroniec, Younan Xia
Summary: This study presents a facile method to produce atomically isolated metal atoms with high loadings in uniform carbon nanospheres. The catalytic activity and selectivity of the obtained single-atom catalysts (SACs) can be controlled by changing the transition metal used.
Review
Chemistry, Physical
Chenxiao Wang, Yifeng Shi, Dong Qin, Younan Xia
Summary: With the mastery over colloidal synthesis of monometallic nanocrystals, the combination of two different metals with intricate architectures has emerged as a new direction of innovation. The core-shell structure has attracted significant scientific interest due to its high controllability and variability. However, the addition of a shell composed of a different metal brings unexpected complications for surface composition, hindering both structural understanding and application performance. This article provides an overview of the opportunities and technical challenges associated with bimetallic core-shell nanocrystals and highlights promising solutions for future research advances.
NANOSCALE HORIZONS
(2023)
Review
Chemistry, Multidisciplinary
Haoyan Cheng, Chenxiao Wang, Dong Qin, Younan Xia
Summary: Galvanic replacement synthesis is a method involving oxidation and dissolution of atoms from a substrate while reducing and depositing a salt precursor on the substrate. It offers advantages over conventional electrosynthesis due to the use of micro/nanostructured materials, which increase surface area and enable intimate mixing with the precursor. The synthesis enables control over the growth pattern of deposited atoms on the substrate, leading to diverse nanomaterials with controllable compositions and shapes.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
