Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19

A Multicenter Phase 2 Randomized Controlled Study on the Efficacy and Safety of Reparixin in the Treatment of Hospitalized Patients with COVID-19 Pneumonia

(2022) Giovanni Landoni et al.   Infectious Diseases and Therapy

High generation of reactive oxygen species from neutrophils in patients with severe COVID-19

(2022) Tonny Veenith et al.   Scientific Reports

Dysregulated Neutrophil Phenotype and Function in Hospitalised Non-ICU COVID-19 Pneumonia

(2022) Kylie B. R. Belchamber et al.   Cells

Elastase and Exacerbation of Neutrophil Innate Immunity are Involved in Multi‐Visceral Manifestations of COVID‐19

(2021) Jean‐Louis Guéant et al.   ALLERGY

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

(2021) Anna C. Aschenbrenner et al.   Genome Medicine

Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients

(2021) Lili Li et al.   Frontiers in Immunology

Impact of SARS-CoV-2 infection on the recovery of peripheral blood mononuclear cells by density gradient

(2021) Maria D. I. Manunta et al.   Scientific Reports

Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution

(2021) Eugenia Z Ong et al.   EBioMedicine

A neutrophil activation signature predicts critical illness and mortality in COVID-19

(2021) Matthew L. Meizlish et al.   Blood Advances

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

(2021) Bruce A. Rosa et al.   Communications Biology

Neutrophils in respiratory viral infections

(2021) Cecilia Johansson et al.   Mucosal Immunology

Prevalence and outcomes of co-infection and superinfection with SARS-CoV-2 and other pathogens: A systematic review and meta-analysis

(2021) Jackson S. Musuuza et al.   PLoS One

Cell-type-specific immune dysregulation in severely ill COVID-19 patients

(2021) Changfu Yao et al.   Cell Reports

A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients

(2021) Samantha M. Morrissey et al.   JCI Insight

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19

(2021) Magda Lourda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets

(2021) Jon Hazeldine et al.   Frontiers in Immunology

Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19

(2021) Rainer Kaiser et al.   JCI Insight

CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death

(2021) Yves Lévy et al.   iScience

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

(2021) Xianwen Ren et al.   CELL

Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19

(2021) Sarthak Sinha et al.   NATURE MEDICINE

Circulating neutrophil subsets in advanced lung cancer patients exhibit unique immune signature and relate to prognosis

(2020) Merav E. Shaul et al.   FASEB JOURNAL

Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer

(2020) Sufang Tian et al.   Journal of Thoracic Oncology

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

COVID-19 and the cardiovascular system

(2020) Ying-Ying Zheng et al.   Nature Reviews Cardiology

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kidney disease is associated with in-hospital death of patients with COVID-19

(2020) Yichun Cheng et al.   KIDNEY INTERNATIONAL

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

(2020) Aymeric Silvin et al.   CELL

Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy

(2020) Leo Nicolai et al.   CIRCULATION

Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19

(2020) Lars M. Koenig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19

(2020) Coraline Radermecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

(2020) Guillaume Carissimo et al.   Nature Communications

Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19

(2020) Jang Hyun Park et al.   Frontiers in Immunology

Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19

(2020) Jun Wang et al.   Frontiers in Immunology

CyTOF mass cytometry reveals phenotypically distinct human blood neutrophil populations differentially correlated with melanoma stage

(2020) Yanfang Peipei Zhu et al.   Journal for ImmunoTherapy of Cancer

ROS-producing immature neutrophils in giant cell arteritis are linked to vascular pathologies

(2020) Lihui Wang et al.   JCI Insight

Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage

(2020) Yan‐Mei Chen et al.   EMBO JOURNAL

Neutrophils mediate Th17 promotion in COVID‐19 patients

(2020) Zuzana Parackova et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort

(2020) David T Arnold et al.   THORAX

Broncho-alveolar inflammation in COVID-19 patients: a correlation with clinical outcome

(2020) Laura Pandolfi et al.   BMC Pulmonary Medicine

Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets

(2020) Krishna Sriram et al.   PHYSIOLOGICAL REVIEWS

Therapeutically Attenuating Neutrophil Recruitment with a CXCR2 Antagonist in Combination with Oseltamivir Ameliorates Influenza Induced Lung Injury and Disease

(2019) Michael L Washburn et al.   Open Forum Infectious Diseases

Chasing the ‘Holy Grail’ – Modulating Neutrophils in Inflammatory Lung Disease

(2019) Charlotte Summers   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutrophil Diversity in Health and Disease

(2019) Carlos Silvestre-Roig et al.   TRENDS IN IMMUNOLOGY

Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

(2019) Pragnesh Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

(2018) Christopher M. Rice et al.   Nature Communications

Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets

(2017) Claudia Eulenberg-Gustavus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Automated mapping of phenotype space with single-cell data

(2016) Nikolay Samusik et al.   NATURE METHODS

Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

(2015) Catherine W. M. Ong et al.   PLoS Pathogens

Identification of an ADAM17 Cleavage Region in Human CD16 (FcγRIII) and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells

(2015) Yawu Jing et al.   PLoS One

Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

(2013) Sara Rørvig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

CXCR2: From Bench to Bedside

(2012) Anika Stadtmann et al.   Frontiers in Immunology

The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature

(2008) Fernanda M. Coelho et al.   ARTHRITIS AND RHEUMATISM