Review
Cell Biology
Lin Lin, Mu-Xin Zhang, Lei Zhang, Dan Zhang, Chao Li, Yun-lun Li
Summary: Atherosclerosis is a chronic inflammatory disorder characterized by plaque buildup in arteries, with vascular cell injury playing a key role. Dysregulation of autophagy, pyroptosis, and ferroptosis are closely related to atherosclerosis development and plaque stability, highlighting potential pharmacological strategies for addressing atherogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qi Wang, Jingyi Sun, Tian Chen, Siyu Song, Yajun Hou, Lina Feng, Cundong Fan, Mingquan Li
Summary: Alzheimers disease is a neurodegenerative disorder with a rapidly increasing mortality rate. Regulation of cell death plays a crucial role in maintaining homeostasis, and studies have found that ferroptosis, pyroptosis, and cuproptosis are closely related to the development of Alzheimers disease.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Qi Wang, Jingyi Sun, Tian Chen, Siyu Song, Yajun Hou, Lina Feng, Cundong Fan, Mingquan Li
Summary: Alzheimer's disease, the most common form of dementia, is characterized by progressive cognitive dysfunction in elderly individuals. Regulatory cell death, including ferroptosis, pyroptosis, and cuproptosis, has been found to be closely related to the occurrence and development of AD. Understanding the molecular mechanisms of these processes may lead to potential therapeutic targets for AD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Sebastiaan Moonen, Marta J. Koper, Evelien Van Schoor, Jolien M. Schaeverbeke, Rik Vandenberghe, Christine A. F. von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Thal
Summary: The study investigated the contribution of pyroptosis, a pro-inflammatory mechanism of cell death downstream of the inflammasome, to neurodegeneration in Alzheimer's disease (AD). The findings suggest the activation of pyroptosis in specific cell types and its potential link to neuron death in AD.
ACTA NEUROPATHOLOGICA
(2023)
Review
Cell Biology
Xin Chen, Jingbo Li, Rui Kang, Daniel J. Klionsky, Daolin Tang
Summary: Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation. Lipoxygenase is the main promoter of ferroptosis, while GPX4 is the central repressor of this process.
Review
Cell Biology
Sheng Gao, Yun Zhang, Meixia Zhang
Summary: This article summarizes the mechanisms of three types of regulated cell death (RCD) in diabetic retinopathy (DR) and analyzes the recent advances in the association between novel RCD forms and DR. These findings provide new insights into the underlying pathogenic mechanisms of DR and propose potential therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Jikai Xu, Jingyu Liu, Qing Li, Guoxun Li, Guijie Zhang, Yan Mi, Ting Zhao, Danyang Mu, Dequan Wang, Kewu Zeng, Yue Hou
Summary: This study found that pterostilbene, a compound isolated from Chinese dragon's blood, can reduce inflammation in Alzheimer's disease (AD). The study demonstrated that pterostilbene can improve learning and memory abilities in AD transgenic mice and reduce microglial activation and A beta aggregation in their hippocampus. This is achieved by blocking the interaction of TLR4 and MD2 to suppress TLR4-mediated inflammation.
Article
Multidisciplinary Sciences
Yin Xu, Nicholas E. Propson, Shuqi Du, Wen Xiong, Hui Zheng
Summary: Studies indicate that microglial-specific autophagy, represented by Atg7, plays a crucial role in regulating lipid metabolism and neuroinflammation. Deletion of Atg7 in microglia leads to a proinflammatory status and exacerbates intraneuronal tau pathology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Geriatrics & Gerontology
Pei Ou-Yang, Zhi-Yu Cai, Zhong-Hao Zhang
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by protein aggregates, neuronal loss, synaptic dysfunction, and neuroinflammation. Impaired microglial autophagy has been shown to contribute to AD pathology by affecting inflammatory response, defective clearance, propagation of A beta and Tau, and synaptic dysfunction. Microglial receptors play a key role in regulating autophagy during AD. Inducing microglial autophagy shows potential as a strategy for AD drug development, based on accumulating evidence.
Article
Dermatology
Li-Ying Huang, Shao-Ting Li, Shiang-Chi Lin, Cheng-Heng Kao, Chien-Hui Hong, Chih-Hung Lee, Liang-Tung Yang
Summary: Atopic dermatitis is characterized by impaired skin barrier. Gsdma1/a3 deficiency leads to defective tight junction formation and stratum corneum maturation, which may be involved in the pathogenesis of atopic dermatitis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jun Huang, Zaoshang Chang, Quzhe Lu, Xuedong Chen, Masoud Najafi
Summary: Cancer resistance to therapy is a significant challenge in cancer treatment, involving reduced induction of cell death and decreased response to anti-tumor immunity. Nobiletin can induce endogenous ROS generation, leading to damage to critical macromolecules and ultimately cell death. Additionally, NOB can induce cancer cell killing by modulating multiple mechanisms of cell death.
Review
Cell Biology
Juntao Cui, Suhan Zhao, Yinghui Li, Danyang Zhang, Bingjing Wang, Junxia Xie, Jun Wang
Summary: Regulated cell death (RCD) is a crucial process in maintaining tissue homeostasis and restoring biological balance, involving various forms of cell death with complex interactions. Understanding of the role of RCD in evolution, development, physiology, and disease is improving, with a focus on key mechanisms of RCD and its critical role in neurodegenerative diseases.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Oncology
Yifan Cheng, Misha Mao, Yong Lu
Summary: YAP plays a critical role in regulating tumor progression and is closely related to programmed cell death (PCD). YAP activity can be regulated by kinase cascade pathways and other proteins. It has been found that YAP can affect multiple forms of PCD and act as a bridge between different forms of PCD in tumor development.
BIOMARKER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Miaomiao Wang, Gan Tang, Congfa Zhou, Hongmin Guo, Zihui Hu, Qixing Hu, Guilin Li
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by chronic neuroinflammation, amyloid beta-protein deposition, and hyperphosphorylated tau protein. Neuroinflammation and microglial activation play significant roles in AD, contributing to neuronal dysfunction and disease progression. Ferroptosis, an iron-dependent form of cell death, accelerates AD by promoting abnormal microglial activation and neuronal dysfunction. Iron dysregulation and neuronal ferroptosis aggravate neuroinflammation and abnormal microglial activation, creating a vicious cycle. This review explores the relationship between ferroptosis, microglia, and AD, emphasizing the role of ferroptosis in chronic neuroinflammation and providing new insights for potential therapeutic targets.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Neurosciences
Qianke Tao, Xiancheng Qiu, Chaojie Li, Jian Zhou, Long Gu, Lihan Zhang, Jinwei Pang, Lifang Zhang, Shigang Yin, Yong Jiang, Jianhua Peng
Summary: This study found that the expression of S100A8 was significantly increased after subarachnoid hemorrhage (SAH). Inhibiting S100A8 in microglial cells improved neural function and reduced neuronal apoptosis in SAH. Furthermore, the depletion of S100A8 inhibited microglial autophagy-dependent ferroptosis, suggesting its potential role as a therapeutic target for SAH-induced early brain injury (EBI).
EXPERIMENTAL NEUROLOGY
(2022)
