期刊
JOURNAL OF SEPARATION SCIENCE
卷 39, 期 23, 页码 4544-4548出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201600810
关键词
Chiral stationary phases; Enantioselectivity; Nano-liquid chromatography; Metal-organic frameworks; Polymer monoliths
资金
- National Natural Science Foundation of China [2152780016, 21175008]
- Office of Science, Office of Basic Energy Sciences, Scientific User Facilities Division of the U.S. Department of Energy [DE-AC02-05CH11231]
A new approach to the preparation of enantioselective porous polymer monolithic columns with incorporated chiral metal-organic framework for nano-liquid chromatography has been developed. While no enantioseparation was achieved with monolithic poly(4-vinylpyridine-co-ethylene dimethacrylate) column, excellent separations of both enantiomers of (+/-)methyl phenyl sulfoxide were achieved with its counterpart prepared after admixing metalorganic framework [Zn-2(benzene dicarboxylate)(l-lactic acid)(dmf)], which is synthesized from zinc nitrate, L-lactic acid, and benzene dicarboxylic acid in the polymerization mixture. These novel monolithic columns combined selectivity of the chiral framework with the excellent hydrodynamic properties of polymer monoliths, may provide a great impact on future studies in the field of chiral analysis by liquid chromatography.
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