Article
Oncology
Xinxin Cheng, Jie Wang, Chunling Liu, Tianduo Jiang, Ningzhi Yang, Dan Liu, Huanhuan Zhao, Zhelong Xu
Summary: Zinc transporters have been found to be associated with the pathogenesis of various human diseases, including cancer. Among these, high expression of ZIP13 is an independent prognostic factor for poor survival in ovarian cancer patients. ZIP13 regulates intracellular zinc distribution, affecting gene expression related to extracellular matrix organization and cytokine-mediated signaling pathway, ultimately activating the Src/FAK pathway and promoting metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Food Science & Technology
Shuhua Yin, Maoping Duan, Bing Fang, Guanghua Zhao, Xiaojing Leng, Tuo Zhang
Summary: Zinc, as a significant micronutrient, plays essential roles in living organisms and is closely associated with disease occurrence. Zinc transporters are crucial in regulating zinc homeostasis, with their structures and dynamics providing insights into the mechanisms of zinc trafficking and regulation. This review elaborates on the structural basis of zinc transport through ZIP and ZnT, the molecular mechanisms of zinc binding and transport, the driving force for zinc transmembrane transport, and the general regulation models of zinc transporters.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Dominik Klaver, Hubert Gander, Gabriele Dobler, Andrea Rahm, Martin Thurnher
Summary: This study reveals how P2Y(11) utilizes IL-1R and canonical signaling pathways to promote the anti-inflammatory and pro-angiogenic properties of human M2 macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Asma Ahmed, Himanshu Tripathi, Krista E. van Meijgaarden, Nirutha Chetan Kumar, Vasista Adiga, Srabanti Rakshit, Chaitra Parthiban, J. Sharon D'Souza, George D'Souza, Mary Dias, Tom H. M. Ottenhoff, Mihai G. Netea, Simone A. Joosten, Annapurna Vyakarnam
Summary: This study characterized the mechanisms of BCG revaccination-induced trained immunity in India and found that revaccination can induce immune responses but does not enhance control of mycobacterial growth. After vaccination, enhanced immune responses to fungal, bacterial, and viral stimuli were observed.
Article
Oncology
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu
Summary: This study confirmed that cytoplasmic protein TRAF2 can be methylated by SMYD2 and contribute to the continuous activation of NF-kappa B signaling pathway. Knocking down SMYD2 showed varying degrees of mitigation in acute and chronic inflammation mouse models. Moreover, lysine-specific demethylase LSD1 was found to resist the methylation of TRAF2 induced by SMYD2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Stephen R. Hennigar, Cassandra Olson, Alyssa M. Kelley, James P. McClung
Summary: This study investigated the expression of zinc transporters in the small intestine of mice and found that Slc39a4 is positively associated with the appearance of Zn-67 in the liver and plasma. Most zinc transporters are expressed in the small intestine, but Slc39a4 predicts fractional zinc absorption and utilization in young mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Immunology
Wenji Zhang, Hui Lin, Mingmin Zou, Qinghua Yuan, Zhenrui Huang, Xiaoying Pan, Wenjuan Zhang
Summary: Nicotine, as an anti-inflammatory alkaloid, has dual roles in treating diseases. It predominantly exhibits anti-inflammatory effects, especially in ulcerative colitis, arthritis, sepsis, and endotoxemia, but may promote and aggravate certain diseases such as periodontitis and gingivitis in oral inflammation. The molecular mechanism of nicotine in these inflammatory diseases involves regulating immune cells, immune factors, and the vagus and acetylcholinergic anti-inflammatory pathways, offering potential value for remedying acute and chronic inflammation in humans.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
H. H. A. C. K. Jayawardhana, Hyo-Geun Lee, N. M. Liyanage, D. P. Nagahawatta, Bomi Ryu, You-Jin Jeon
Summary: The brown seaweed, Scytosiphon lomentaria, has anti-inflammatory properties and its extract SLCF5 can inhibit nitric oxide production in macrophages, showing potential for treating inflammatory disorders.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Agricultural Engineering
Nidal Jaradat, Mohammad Qneibi, Mohammed Hawash, Nawaf Al-Maharik, Mohammad Qadi, Murad N. Abualhasan, Ola Ayesh, Jamila Bsharat, Malak Khadir, Roaa Morshed, Saja Yaaqbeh, Shaima'a Marei, Shahed Hamayel, Ahmed Mousa, Maysa Daqqa, Sosana Bdir
Summary: Artemisia arborescens essential oil from Bethlehem and Jenin regions in Palestine exhibit antimicrobial and cytotoxic effects, different COX enzyme inhibitory activities, and significant influences on neuronal receptors. The essential oils may have therapeutic potential in preventing and treating pathogenic infections, cancers, inflammations, and neurodegenerative diseases.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Medicine, Research & Experimental
Hong-Beom Park, Bum-Chae Choi, Kwang-Hyun Baek
Summary: In this study, potential substrates of ITI-H4 were identified through immunoprecipitation and MALDI-TOF/MS analysis. Among them, PGK1 was found to be a binding protein of ITI-H4. PGK1 increases ITI-H4 expression and blocks its cleavage mediated by KLKB1. It also inhibits pro-inflammatory response by inhibiting the JAK2/STAT3 signaling pathway. Therefore, PGK1 is expected to have cellular functions in the pathogenesis of ITI-H4-related inflammatory diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sara Standoli, Cinzia Rapino, Camilla Di Meo, Agnes Rudowski, Nicole Kaempfer-Kolb, Luisa Michelle Volk, Dominique Thomas, Sandra Trautmann, Yannick Schreiber, Dagmar Meyer zu Heringdorf, Mauro Maccarrone
Summary: Microglia, the immune cells of the central nervous system, have important roles in brain homeostasis and various neurological diseases. This study investigates the interaction between the endocannabinoid system and the sphingosine kinase/sphingosine-1-phosphate system in microglia. The results reveal that inhibiting the fatty acid amide hydrolase enzyme and activating the cannabinoid 2 receptor have anti-inflammatory effects and prevent the transcription of pro-inflammatory SphK1 and SphK2 in microglia cells challenged with lipopolysaccharide. The findings suggest the development of inhibitors for these enzymes as potential treatments for neuroinflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Kelsie J. Anson, Giulia A. Corbet, Amy E. Palmer
Summary: In this study, the researchers investigated how changes in intracellular zinc ion levels affect kinase signaling pathways using fluorescent biosensors and cell perturbations. The results showed that zinc ion fluctuations are not toxic and do not activate stress-dependent kinase signaling. Additionally, the study demonstrated that while zinc ions can inhibit phosphatases, ERK and Akt are primarily activated through upstream signaling pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Microbiology
Pengfei Zhai, Yanfei Chai, Ling Lu
Summary: This paper summarized potential zinc homeostasis regulators in A. fumigatus and classified them according to localization and function. It also discussed the future prospects of using these regulators as potential antifungal targets for treating invasive aspergillosis.
Article
Pharmacology & Pharmacy
Omer Bahceli, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Mehmet Furkan Horat, Seyhan Sahan-Firat, Bahar Tunctan
Summary: The study demonstrates that bexarotene can alleviate LPS-induced inflammatory hyperalgesia by reducing pro-inflammatory signaling pathways and enhancing anti-apoptotic signaling pathways in the central nervous system of mice.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shunfeng Liu, Nan Wang, Yaqian Long, Zhuan Wu, Shouhong Zhou
Summary: Zinc is essential for normal growth and development in the human body. The homeostasis of zinc in the central nervous system is closely linked to the development of neuroinflammation. Disturbances in synaptic zinc homeostasis can lead to neuroinflammation and neurodegenerative diseases. Maintaining proper zinc levels through supplementation can improve immunity and prevent neuroinflammation. This article highlights the importance of maintaining synaptic zinc homeostasis in preventing neuroinflammation.
Article
Food Science & Technology
Marijke van der Laan, Anna Buttgenbach, Jana Wolf, Lothar Rink, Inga Wessels
Summary: This study demonstrates the opposing effects of zinc on GM-CSFR surface expression in monocytes and PMN. Zinc and GM-CSF, when used in optimized concentrations, can enhance MAPK signaling and increase the expression of Mcl-1 in PMN. The study provides a basis for further in vivo studies on the therapeutic value of zinc in patients with disrupted GM-CSF signaling.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Multidisciplinary Sciences
Kristian Kniha, Lothar Rink, Jana Wolf, Stephan Christian Moehlhenrich, Florian Peters, Marius Heitzer, Frank Hoelzle, Ali Modabber
Summary: In this study, implant outcomes in rats were compared between systemic alendronate and zoledronate acid drug administrations, showing significant effects of zoledronic acid on IL-6 release around titanium implants and alendronic acid on IL-6 release around natural teeth. Material incompatibilities and in vitro stimulation of rat spleen cells with titanium and zirconia nanoparticles were also evaluated.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Christina Schier, Jana Foerster (nee Reiter), Monika Heupel, Philipp Doerner, Michael Klaas, Wolfgang Schroeder, Lothar Rink, Alan J. Slusarenko, Martin C. H. Gruhlke
Summary: Allicin, a volatile substance produced by injured garlic plants, shows broad antimicrobial activity against selected fungi. It has comparable efficacy to the commonly used antifungal drug amphotericin B. Our study suggests that allicin may be a potential candidate for antifungal therapy in lung and upper respiratory tract infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Theresa Scheurer, Jan Steffens, Agnieszka Markert, Miriam Du Marchie Sarvaas, Christoph Roderburg, Lothar Rink, Frank Tacke, Tom Luedde, Thomas Kraus, Ralf Baumann
Summary: This study investigates the impact of occupationally relevant ultrafine zinc/copper (Zn/Cu) welding fumes on noncoding RNAs (lncRNAs). The results show that, except for CoroMarker, the regulation patterns of the tested lncRNAs in both in vitro and in vivo experiments are consistent and in line with their known functions. Notably, the upregulation of CDR1as, a potential risk marker for cardiovascular diseases, contributes to understanding the underlying mechanisms of subclinical inflammation induced by Zn/Cu exposure in metal workers.
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Chiara A. De Benedictis, Sarah Trame, Lothar Rink, Andreas M. Grabrucker
Summary: This study investigated the zinc intake and bioavailability of over 250 women (both pregnant and non-pregnant) in Ireland and found that 58% of participants were at risk of inadequate zinc intake, with 29% potentially being zinc deficient. The low zinc intake was primarily a result of insufficient consumption of zinc-rich foods and relatively higher intake of foods rich in phytate, a major inhibitor of zinc uptake.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Geriatrics & Gerontology
Bastian Robinson Baarz, Thea Laurentius, Jana Wolf, Inga Wessels, Leo Cornelius Bollheimer, Lothar Rink
Summary: The deficiency of zinc can lead to overexpression of CREM alpha, resulting in impaired IL-2 production in the elderly. However, short-term zinc supplementation can effectively reverse this process and improve immune function.
Article
Biochemistry & Molecular Biology
Wenlei Liu, Jana Jakobs, Lothar Rink
Summary: Pantoprazole treatment reduces the production and secretion of IFN-gamma and IL-2 in T cells by regulating the expression of Zip8 and pCREB or CREM alpha, respectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Sarah Trame, Andreas Brueggemann, Lothar Rink
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Food Science & Technology
Stefanie Ramona Weisenfeld, Jana Jakobs, Lothar Rink
Summary: ScopeZinc is essential for immune system balance, but the exact mechanisms are still unclear. This study explores the interaction between zinc and the tricarboxylic acid cycle (TCA) and their impact on immune modulation. The results show that zinc and citrate can reduce interferon-gamma (IFN gamma) expression and pro-inflammatory T helper cells (Th1 and Th17), while zinc increases regulatory T cells and citrate decreases them. These findings have implications for understanding the immunosuppressive effects of blood products and the potential risks of high citrate consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biology
Kanokwan Sansuwan, Orapint Jintasataporn, Lothar Rink, Supawit Triwutanon, Inga Wessels
Summary: This article investigates the effects of zinc deficiency and zinc supplementation on Asian sea bass aquacultures. The study finds that altering extracellular zinc conditions significantly affects gene expression and cellular zinc levels in Asian sea bass cells. Zinc deficiency induces a stress response in these cells, which can be prevented with sufficient zinc supplementation. Therefore, zinc supplementation may be recommended to optimize aquacultures of Asian sea bass.
Article
Biochemistry & Molecular Biology
Mary-Ann Puppa, Jana Jakobs, Lothar Rink
Summary: This study investigated the effect of tert-butyl-hydrochinone (tBHQ) stimulation on human PBMC under normal and zinc-depleted conditions. The results showed that zinc influenced the mRNA and protein expression of Nrf2, NQO1, and HO-1, and zinc supplementation inhibited HDAC3 activity, stabilizing Nrf2. Therefore, zinc supplementation has beneficial effects on the redox balance in human cells.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Asad Shahzad, Lothar Rink, Inga Wessels
Summary: This study aims to investigate the correlation between zinc deficiency and MMP-9 transcriptional regulation, focusing on epigenetics as the possible mechanism behind zinc deficiency-induced changes. The effect of differentiation and zinc deficiency on MMP-9 expression and MMP9 promoter accessibility was investigated using the acute promyelocytic cell line NB4. The results showed that zinc deficiency led to upregulated MMP-9 gene expression and increased accessibility of the MMP-9 promoter, while zinc resupplementation reversed these effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yifan Peng-Winkler, Anna Buttgenbach, Lothar Rink, Inga Wessels
Summary: Zinc supplementation prior to heat shock increases the expression of HSP70 in the human immune system, providing cytoprotective effects in tissue cells during inflammation. The effect of alterations in the cellular zinc status on HSP70 expression and cell survival in human monocytes and lymphocytes was investigated. It was found that zinc deficiency and supplementation enhanced heat shock-induced HSP70 expression, and zinc deficiency further increased cell death induced by heat shock. This study highlights the importance of an optimal cellular zinc status and provides insight into the mechanism behind zinc's influence on HSP70 expression in human leukocytes.
