Article
Immunology
Ximo Xu, Chengsheng Ding, Hao Zhong, Wei Qin, Duohuo Shu, Mengqin Yu, Naijipu Abuduaini, Sen Zhang, Xiao Yang, Bo Feng
Summary: This study identified three distinct cuprotosis patterns in colorectal cancer patients, which are associated with the tumor microenvironment and immune regulation. Through single-cell transcriptome analysis, it was found that these patterns influence the prognosis of colorectal cancer patients. These findings provide guidance for the treatment of colorectal cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tiegang Li, Zheng Yan, Weiqi Wang, Rixin Zhang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Min Yang
Summary: The study revealed that high SEMA6B expression was associated with poor prognosis and the tumor immunosuppressive microenvironment in CRC patients, suggesting SEMA6B as a potential novel prognostic biomarker for CRC and providing insights for developing CRC-targeted immunotherapies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Multidisciplinary Sciences
Xueli Wang, Yu Zhang, Niping Song, Kaiqiang Li, Siyun Lei, Jianwei Wang, Zhen Wang, Wei Zhang
Summary: This study aimed to investigate the role of cartilage intermediate layer protein 2 (CILP2) in colorectal cancer (CRC) progression and immune response. The findings showed that elevated CILP2 expression was associated with adverse clinical features and immune cell infiltration, indicating it has potential as a detrimental biomarker for CRC survival.
Article
Oncology
Hanna Elomaa, Maarit Ahtiainen, Sara A. Vaeyrynen, Shuji Ogino, Jonathan A. Nowak, Mai Chan Lau, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppaelae, Jan Boehm, Jukka-Pekka Mecklin, Teijo Kuopio, Juha P. Vaeyrynen
Summary: The expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment are inadequately characterised. This study found that PD-L1(+) macrophages and PD-1(+) T cells were associated with better clinical outcomes in colorectal cancer patients. These findings enhance the understanding of immune checkpoints in the tumor microenvironment and could contribute to the development of improved immunotherapies.
BRITISH JOURNAL OF CANCER
(2023)
Article
Immunology
Jiahui Wang, Yixin Kang, Yuxuan Li, Liang Sun, Jun Zhang, Senmi Qian, Ke Luo, Yi Jiang, Lichao Sun, Fangying Xu
Summary: This study found that the subcellular localization of GSDMD is associated with colorectal cancer progression and immune reaction. High expression of cytoplasmic GSDMD is correlated with a better prognosis and improved efficacy of chemotherapy, while nuclear GSDMD expression may indicate deeper infiltration depth.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Lu Han, Shiyun Chen, Zhe Luan, Mengjiao Fan, Yanrong Wang, Gang Sun, Guanghai Dai
Summary: Colon cancer is a complex disease involving interactions between cancer cells and the immune microenvironment. Recent studies have shown that microRNAs (miRNAs) play a critical role in gene regulation in colon cancer, particularly in modulating the immune microenvironment. Identifying miRNAs associated with colon cancer and their regulation of immune function-related genes could provide insights into prognosis and guide personalized treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Wenlong Chen, Yiwen Wang, Haitao Gu, Yi Zhang, Cong Chen, Tingting Yu, Tao Chen
Summary: This study systematically evaluated the interaction between extracellular matrix (ECM) remodeling and prognosis and the immune microenvironment in colorectal cancer (CRC) patients. It developed a prognostic model based on two ECM remodeling-related genes (MEIS2, SLC2A3) and showed their reliable predictive ability. The study also found significant differences in the tumor microenvironment and immune function between high- and low-risk CRC patients. Overall, this study has important clinical implications for immunotherapy and individualized treatment in CRC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Chang Liu, Zhihua Lu, Jun Yan, Dong Xue, Xiaoyu He, Wenbo Huang, Qi Sun, Wei Zhao, Fanni Li
Summary: Through analysis of the TCGA and GEO databases, we identified 7 genes associated with colorectal cancer liver metastases and constructed a gene signature for predicting the prognosis of colorectal cancer patients. We also found that the HAMP gene plays a promoting role in colorectal cancer development and is associated with tumor mutation burden, DNA mismatch repair genes, and microsatellite instability. These findings have important implications for guiding immunotherapeutic strategies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Xianzhe Li, Minghao Xie, Shi Yin, Zhizhong Xiong, Chaobin Mao, Fengxiang Zhang, Huaxian Chen, Longyang Jin, Ping Lan, Lei Lian
Summary: This study developed and validated a novel immune prognostic signature based on six differentially expressed IRGs for predicting disease-free survival and immune status in patients with stage II CRC. The high-risk group exhibited a higher percentage of infiltrated immune cells. The accuracy of the signature was confirmed through experimental validation.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Xiaojun Zhang, Yilan Huang, Qian Li, Yiqing Zhong, Yuanzhou Zhang, Jingying Hu, Rui Liu, Xiaoying Luo
Summary: The developed Senescence Risk Score (SRRS) in this study provides a powerful prognostic tool for colorectal cancer (CRC) and paves the way for novel therapeutic strategies, underscoring its potential in transforming CRC patient management.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yihao Mao, Yuqiu Xu, Jiang Chang, Wenju Chang, Yang Lv, Peng Zheng, Zhiyuan Zhang, Zhiqiang Li, Qi Lin, Wentao Tang, Dexiang Zhu, Meiling Ji, Guodong He, Qingyang Feng, Jianmin Xu
Summary: This study explores the immune phenotypes and immune escape mechanisms of colorectal cancer (CRC) and provides inspiration for further research on CRC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yuanyuan Wang, Wei Li, Xiaojing Jin, Xia Jiang, Shang Guo, Fei Xu, Xingkai Su, Guiqi Wang, Zengren Zhao, Xiaosong Gu
Summary: In this study, a novel thirteen immune-related genes signature was established as a validated prognostic predictor for CRC patients, which may assist in individualized treatment decisions.
Article
Oncology
Jin-Sen Weng, Jie-Ping Huang, Wei Yu, Jun Xiao, Fang Lin, Kang-Ni Lin, Wei-Dong Zang, Yong Ye, Jing-Ping Lin
Summary: The study found that mitophagy is closely related to the survival, immune infiltration, and chemotherapy response of colorectal cancer patients. Clustering analysis was performed on CRC patients, and three different patient groups with distinct clinicopathological features and prognosis were identified. A risk model based on mitophagy-related genes was developed, and it was found that low-risk patients have better prognosis, higher enrichment of immune activating cells, and better response to chemotherapy.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Cell Biology
An Zhi Zhang, Xin Yuan, Wei Hua Liang, Hai Jun Zhang, Ya Li, Yu Fang Xie, Jiang Fen Li, Chen Hao Jiang, Fan Ping Li, Xi Hua Shen, Li Juan Pang, Hong Zou, Wen Hu Zhou, Feng Li, Jian Ming Hu
Summary: Immunotherapy has rapidly developed and become an important method for treating gastric cancer. The presence of tumor infiltrating immune cells and immune-related genes in the tumor microenvironment greatly influence tumor progression and prognosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Qianhui Xu, Shaohuai Chen, Yuanbo Hu, Wen Huang
Summary: This study comprehensively investigated the role of immune cell infiltration patterns in tumor progression and clinical outcomes in breast cancer. Different immune infiltration patterns were identified, with high ICI scores suggesting immune-exhausted phenotype and low ICI scores corresponding to immune-activated phenotype with potential immunotherapeutic advantage. The findings contribute to a better understanding of the complexity of the tumor immune microenvironment and could potentially optimize precision immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Environmental
Xiao Zhang, Baokang Xu, Xi Li, Xiulei Fan, Jiankun Zhang, Yang Yu, Yongjun Sun
Summary: In this study, a nanotubular carbon nitride photocatalyst was prepared and applied to degrade chloroquine phosphate in a peroxymonosulfate activation system. The unique structure and excellent photoelectrochemical properties of the photocatalyst optimized its active site exposure and charge transport performance, enabling efficient degradation of chloroquine phosphate. The anaerobic environment enhanced the degradation performance and prevented competitive adsorption and consumption of oxygen and peroxymonosulfate, maximizing the transfer of photogenerated charges for activation and degradation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Jing Sun, Yun Li, Haiou Song, Hongxiang Li, Qian Lai, Gusunkiz Egabaierdi, Qimeng Li, Shupeng Zhang, Huan He, Aimin Li
Summary: The shortage of freshwater supplies has hindered societal development. Capacitive deionization (CDI) is a promising solution for seawater and brackish water desalination, with electrode materials playing a crucial role in its performance. This study successfully synthesized a high-capacitance CNTs-b-MoS2 composite and combined it with activated carbon (AC) for CDI, demonstrating improved capacitance and desalination capacity. The CNTs-b-MoS2/AC composite shows potential as an advanced and cost-effective CDI electrode material.
Article
Pathology
Xiaohang Yang, Jingjing Yin, Yu Fu, Yuanming Shen, Chuyao Zhang, Shuzhong Yao, Congjian Xu, Min Xia, Ge Lou, Jihong Liu, Bei Lin, Jianliu Wang, Weidong Zhao, Jieqing Zhang, Wenjun Cheng, Hongyan Guo, Ruixia Guo, Fengxia Xue, Xipeng Wang, Lili Han, Xiaomao Li, Ping Zhang, Jianguo Zhao, Wenting Li, Yingyu Dou, Zizhuo Wang, Jingbo Liu, Kezhen Li, Gang Chen, Chaoyang Sun, Pengming Sun, Weiguo Lu, Qin Yao
Summary: In this study, the mode of myometrial invasion diagnosis in FIGO stage I non-endometrioid carcinoma was explored and the differences in diagnostic efficiency among intraoperative frozen section (IFS), intraoperative gross examination (IGE), magnetic resonance imaging (MRI), and computed tomography (CT) were evaluated. It was found that IFS is a reliable method that should be routinely performed in clinical practice for accurately assessing myometrial invasion in non-endometrioid endometrial carcinoma patients.
DIAGNOSTIC PATHOLOGY
(2023)
Article
Optics
Yulong Cui, Xin Tian, Binyu Rao, Wei Huang, Hao LI, Wenxi Pei, Meng Wang, Zilun Chen, Zefeng Wang
Summary: The stimulated Raman scattering (SRS) process in gas-filled hollow-core fiber is mainly used for wavelength conversion, with the potential to produce narrow-linewidth and high-power fiber laser output. However, the current research is limited to a few watts power level due to coupling technology constraints. By fusion splicing between the end-cap and the hollow-core photonics crystal fiber, several hundred watts pump power can be coupled into the hollow core.
Article
Plant Sciences
Xiaochen Jia, Hongyan Zhang, Hongqiang Qin, Kuikui Li, Xiaoyan Liu, Wenxia Wang, Mingliang Ye, Heng Yin
Summary: In this study, a functional plant AGM (AtAGM) was identified from Arabidopsis thaliana, with a significant role in UDP-GlcNAc biosynthesis pathway. AtAGM catalyzes the isomerization of GlcNAc-1-P and GlcNAc-6-P, and has broad catalytic activity on different phosphohexoses. The decrease in UDP-GlcNAc content in AtAGM mutants resulted in impaired protein O-GlcNAcylation and temperature-dependent growth defects in seedlings.
Article
Agronomy
Kefeng Cao, Shiyun Zhang, Yi Chen, Jianfen Ye, Yingying Wei, Shu Jiang, Xingfeng Shao
Summary: In this study, we found that the ethylene-responsive transcription factor PpRAP2.12 directly binds to the PpVIN2 promoter and enhances its activity, leading to increased invertase activity and decreased sucrose levels in peach fruit. Overexpression of PpRAP2.12 in tobacco reduces cold tolerance and increases VIN expression and activity, as well as reactive oxygen species production. Therefore, PpRAP2.12 acts as a negative regulator of cold resistance in plants and could be a potential target for mitigating chilling injury in peach fruit.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Psychiatry
Xue Li, Qing Liu, Zhaonian Chen, Yalin Li, Ying Yang, Xiujuan Wang, Xiaoge Guo, Binbin Luo, Yan Zhang, Han Shi, Luwen Zhang, Xi Su, Minglong Shao, Meng Song, Suqin Guo, Lingzhong Fan, Weihua Yue, Wenqiang Li, Luxian Lv, Yongfeng Yang
Summary: This study found that abnormal brain activity is associated with schizophrenia, and treatment can lead to changes in brain activity. Specifically, abnormal activity in the right medial region of the superior frontal gyrus can serve as a biomarker for treatment response in schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Chemistry, Analytical
Chang Liu, Zihao Deng, Yanan Deng, Kaijing Yuan, Miao Hu, Lili Yuan, Jianmei Zou, Jinfang Nie, Yun Zhang
Summary: This work presents a new class of universal nanoprobe-free colorimetric assay for amplified detection of nanomolar heavy metal ions based on analyte-triggered multi-component complexation. The method utilizes Tyndall effect signaling and demonstrated the ability to detect Cu2+ in a linear range of 156 nM-120 mu M with a LOD of -38 nM. It also showed selective detection of Cd2+ with a LOD down to -1.27 nM and satisfactory recovery results in real water samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Minggang Xie, Chunguang Li, Siqi Zhang, Zhe Zhang, Yuxin Li, Xiao-Bo Chen, Zhan Shi, Shouhua Feng
Summary: The development of fast charging materials is crucial for large-scale and sustainable energy storage. This study presents a novel Bi2Se3-ZnSe heterostructure as an excellent fast charging material for Na+ storage. The introduction of ultrathin Bi2Se3 nanoplates with topological insulator metallic surfaces greatly reduces charge transfer resistance and improves overall electrical conductivity. The composite exhibits excellent high-rate performance and electrochemical stability, making it a promising alternative for further exploration of topological insulators and advanced heterostructures.
Article
Neurosciences
Zhi Chai, Teng Ma, Yunhong Li, Qiuyuan Chen, Yali Kang, Jinping Sun, Tao Peng, Nina Wang, Chengjun Yu, Lijuan Wang, Xiaolin Hou, Wei Wang, Yin Wang
Summary: This study investigated the potential of Fer-1 in inhibiting inflammation and treating myelin-related diseases by inhibiting microglia ferroptosis and decreasing the release of TNF-α, which can alleviate oligodendrocyte precursor cell (OPC) necroptosis.
Review
Pathology
Fan Yu, Haihong He, Yiwen Zhou
Summary: A comprehensive approach is required in the fight against cancer, with molecular strategies playing a critical role. Long non-coding RNAs (lncRNAs), which are longer than 200 nucleotides, have been found to regulate gene expression, protein localization, and chromatin remodeling, and influence cancer development. Specifically, the lncRNA RHPN1-AS1 has been shown to be significantly upregulated and exert oncogenic functions in various cancer cell lines. This review provides an overview of the roles played by RHPN1-AS1 in the emergence of different types of cancer, focusing on its biological and clinical functions.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Polymer Science
Shengda Wang, Shenghui Lou, Penghui Fan, Li Ma, Jie Liu, Tao Tang
Summary: In order to enhance the flame-retardant performance of epoxy thermosets while maintaining other properties, a new aromatic imine-containing DOPO-based bisphenol, DOPO-AI, was synthesized. When the mass of DOPO-AI was 25% of DGEBA, the resulting epoxy thermoset EP/20DOPO-AI exhibited excellent flame-retardant properties, showing V-0 rating with a limiting oxygen index of 35.4%. In addition, EP/20DOPO-AI also showed a reduction in heat release and an increase in char-forming ability.
POLYMER DEGRADATION AND STABILITY
(2023)
Article
Environmental Sciences
Liguo Cao, Zhengchao Zhou, Kexin Zhang, Ning Wang, Zhangwen Liu
Summary: Cryoconite, dark sediments on the surface of glaciers, has exceptional capacity to accumulate plutonium isotopes, which are derived from global fallout and Chinese nuclear test sites. These findings are important for understanding the fate of plutonium isotopes in the cryosphere and for future radioactivity evaluation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Chemical
Xindan Fan, Qintie Lin, Kehuan Xu, Junli Zheng, Jian Sun, Hengyi Fu, Yuxin Liu, Yongjie Ma, Jin He
Summary: In this study, an N-doped modified graphitized iron-based carbon nanomaterial was prepared for the rapid degradation of ciprofloxacin. The nitrogen modification enables a nonradical degradation process, and the degradation intermediates and pathway were identified. This study provides a new perspective for the removal of antibiotics from aqueous solutions.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Construction & Building Technology
Yuzhu Guo, Xudong Chen, Jin Wu, Tao Ji, Yingjie Ning
Summary: This study investigates the potential for quantitative monitoring of the fracture process zone (FPZ) at the shotcrete-rock interface using acoustic emission (AE) and digital image correlation (DIC). The AE intensity signal characteristics during damage to the shotcrete-rock interface are analyzed, and a new parameter, Tb-value, is proposed to quantitatively characterize the FPZ. The results show that the Tb-value can locate and visually characterize the location of the FPZ within the specimen, as well as enable the quantitative determination of the FPZ. This provides a new approach for localizing and quantitatively monitoring cracks and FPZs using AE techniques.
STRUCTURAL CONTROL & HEALTH MONITORING
(2023)
