Tumor cells fail to present MHC-II–restricted epitopes derived from oncogenes to CD4+ T cells

Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function

(2022) Joshua R. Veatch et al.   CANCER CELL

Landscape of helper and regulatory antitumour CD4+ T cells in melanoma

(2022) Giacomo Oliveira et al.   NATURE

Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers

(2022) Frank J. Lowery et al.   SCIENCE

Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

(2021) Amélie Cachot et al.   Science Advances

Tumor Immunity and Immunotherapy for HPV-Related Cancers

(2021) Achraf A. Shamseddine et al.   Cancer Discovery

Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting

(2021) Adham S. Bear et al.   Nature Communications

Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer

(2020) David Y. Oh et al.   CELL

Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients

(2020) Kunal H. Bhatt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity

(2020) Stephen T. Ferris et al.   NATURE

Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients

(2019) Gal Cafri et al.   Nature Communications

Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer Patients, Including Recurrent Oncogenic KRAS and ERBB2 (Her2) Driver Mutations

(2019) Joshua R. Veatch et al.   Cancer Immunology Research

Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction

(2019) Jennifer G. Abelin et al.   IMMUNITY

T-Cell Receptor Gene Therapy for Human Papillomavirus–Associated Epithelial Cancers: A First-in-Human, Phase I/II Study

(2019) Stacey L. Doran et al.   JOURNAL OF CLINICAL ONCOLOGY

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

(2019) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

MHC-II neoantigens shape tumour immunity and response to immunotherapy

(2019) Elise Alspach et al.   NATURE

CD4+ T cell-mediated rejection of MHC class II-positive tumor cells is dependent on antigen secretion and indirect presentation on host APCs

(2018) Ole Audun Werner Haabeth et al.   CANCER RESEARCH

Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma

(2018) Joshua R. Veatch et al.   JOURNAL OF CLINICAL INVESTIGATION

MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma

(2018) Scott J. Rodig et al.   Science Translational Medicine

CD4 + T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness

(2017) Tomasz Ahrends et al.   IMMUNITY

Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II–Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3

(2017) Yong-Chen Lu et al.   JOURNAL OF CLINICAL ONCOLOGY

Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens

(2017) Xuefeng Liu et al.   Nature Protocols

Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

(2017) Sanja Stevanović et al.   SCIENCE

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

(2016) Eric Tran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Present Yourself! By MHC Class I and MHC Class II Molecules

(2016) Kenneth L. Rock et al.   TRENDS IN IMMUNOLOGY

Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6

(2015) L. M. Draper et al.   CLINICAL CANCER RESEARCH

SpeedSeq: ultra-fast personal genome analysis and interpretation

(2015) Colby Chiang et al.   NATURE METHODS

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression

(2015) Jelle Scholtalbers et al.   Genome Medicine

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

Nonclassical Antigen-Processing Pathways Are Required for MHC Class II-Restricted Direct Tumor Recognition by NY-ESO-1-Specific CD4+ T Cells

(2013) J. Matsuzaki et al.   Cancer Immunology Research

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

Incorporation of Transmembrane Hydrophobic Mutations in the TCR Enhance Its Surface Expression and T Cell Functional Avidity

(2012) A. Haga-Friedman et al.   JOURNAL OF IMMUNOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes

(2010) R. Bos et al.   CANCER RESEARCH

An Unexpectedly Large Polyclonal Repertoire of HPV-Specific T Cells Is Poised for Action in Patients with Cervical Cancer

(2010) Peggy J. de Vos van Steenwijk et al.   CANCER RESEARCH

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS