Article
Oncology
Yueqin Sun, Weitao Shen, Shulu Hu, Qiong Lyu, Qiongyao Wang, Ting Wei, Weiliang Zhu, Jian Zhang
Summary: This study found that METTL3 is a marker for poor prognosis in small cell lung cancer (SCLC) and is highly expressed in chemoresistant SCLC cells. METTL3 promotes SCLC chemoresistance by positively regulating mitophagy. METTL3 induces m6A methylation of DCP2 and causes the degradation of DCP2, which promotes mitochondrial autophagy through the Pink1-Parkin pathway, leading to chemotherapy resistance. Additionally, a novel METTL3 inhibitor, STM2457, can reverse SCLC chemoresistance.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zhen Liu, Shan Shan, Zixin Yuan, Fengying Wu, Ming Zheng, Ying Wang, Jun Gui, Wei Xu, Chunhong Wang, Tao Ren, Zhenke Wen
Summary: This study identifies hypermitophagy as a characteristic of human lung cancer stem cells (CSCs), promoting metabolic adaption through the Notch1-AMPK axis to drive CSC expansion.
Article
Biochemistry & Molecular Biology
Mika Iwai, Taisuke Kajino, Masahiro Nakatochi, Kiyoshi Yanagisawa, Yasuyuki Hosono, Hisanori Isomura, Yukako Shimada, Motoshi Suzuki, Ayumu Taguchi, Takashi Takahashi
Summary: In this study, a novel lncRNA called TILR was identified as a constitutive negative regulator of p53 expression, playing a role in the development of lung cancer. It was found that TILR interacts with the protein PCBP2 and binds to p53 mRNA, leading to the suppression of p53 expression and activation of downstream genes involved in apoptosis. Furthermore, TILR was shown to be involved in a positive feedback loop with p53 and Fanconi anemia pathway genes. These findings highlight the importance of TILR in regulating p53 expression and apoptosis in lung cancer.
Article
Biochemistry & Molecular Biology
Caihong Wang, Shaosen Zhang, Boyuan Ma, Yan Fu, Yongzhang Luo
Summary: This research uncovers a mechanism by which mutant p53 regulates the transcription of RCP to influence lung cancer progression, providing new insights for treating p53 mutant lung cancer.
Article
Cell Biology
Quangdon Tran, Hyunji Lee, Jae Hun Jung, Seung-Hee Chang, Robin Shrestha, Gyeyeong Kong, Jisoo Park, Seon-Hwan Kim, Kyu-Sang Park, Hyun-Woo Rhee, Jeanho Yun, Myung-Haing Cho, Kwang Pyo Kim, Jongsun Park
Summary: The study found that LETM1 is overexpressed in lung cancer cells, leading to fragmentation of mitochondria and upregulation of mitophagy. Glucose-regulated protein 78 (GRP78) was found to interact with LETM1, and this interaction was enhanced in cells treated with a mitophagy-inducing chemical. Furthermore, the study showed that honokiol, a GRP78 inhibitor, blocked LETM1-mediated mitophagy, and CRISPR/Cas9-mediated GRP75 knockout inhibited LETM1-induced autophagy.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Cheng Zeng, Tingting Zou, Junyan Qu, Xu Chen, Suping Zhang, Zhenghong Lin
Summary: This study demonstrates that CVB-D can induce mitophagy in lung cancer cells by activating the p65/BNIP3/LC3 axis, leading to enhanced apoptosis and inhibited tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ciara Murphy, Gloria Gornes Pons, Anna Keogh, Lisa Ryan, Lorraine Mccarra, Chris Maria Jose, Shagun Kesar, Siobhan Nicholson, Gerard J. Fitzmaurice, Ronan Ryan, Vincent Young, Sinead Cuffe, Stephen P. Finn, Steven G. Gray
Summary: This study investigated the expression and potential clinical utility of JADE2 in non-small cell lung cancer (NSCLC). The results showed that JADE2 expression is significantly altered in NSCLC and high expression of JADE2 is associated with better overall survival. The study also identified associations between JADE2 expression and tumor mutational burden and immune cell infiltration, as well as potential new drugs targeting JADE2. Overall, JADE2 may have potential diagnostic, prognostic, and therapeutic implications in NSCLC.
Article
Chemistry, Inorganic & Nuclear
Huixian Zheng, Chaoyi Hu, Yunyun Quan, Xiaoxia Ye, Xiangchao Shi, Zijian Guo, Xiaoyong Wang
Summary: A phenanthroline copper(ii) complex CPT8 modified with an alkyl chain-linked triphenylphosphonium group showed potent antiproliferative activity against TNBC cells and induced mitophagy through activation of PINK1/Parkin and BNIP3 pathways. It also exhibited anti-angiogenic effects by decreasing the tube formation ability of HUVEC and downregulating the expression of Nrf2, VEGF, and CD34. Furthermore, CPT8 inhibited vasculogenic mimicry formation and suppressed the metastatic potential of MDA-MB-231 cells, making it a promising metal drug candidate for TNBC treatment.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Shweta Arora, Prithvi Singh, Gulnaz Tabassum, Ravins Dohare, Mansoor Ali Syed
Summary: This study identifies a miR-mediated mechanism of sphingolipid reprogramming in non-small cell lung cancer (NSCLC), where miR-495-3p targets Sphk1 to induce lethal mitophagy, effectively suppressing tumor formation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Hongyu Qiao, Zhongxiang Ding, Youcai Zhu, Yuguo Wei, Baochen Xiao, Yongzhen Zhao, Qi Feng
Summary: This study investigated the correlation between TP53 gene expression and radiomic features in lung cancer, showing a high level of association between the two. Through model prediction, the type of TP53 gene mutation in lung cancer lesions can be accurately predicted.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Editorial Material
Ecology
Fritz Vollrath
Summary: Elephants have testicles that do not descend, leading to potential problems with sperm production and DNA replication/repair. Interestingly, elephants also have multiple copies of a gene that encodes the p53 protein. It is speculated that the multiplication of the TP53 gene complex in elephants may serve to protect their germline cells rather than to combat cancer.
TRENDS IN ECOLOGY & EVOLUTION
(2023)
Article
Oncology
Bing Wei, Jiadong Zhao, Jun Li, Junnan Feng, Manman Sun, Zhizhong Wang, Chao Shi, Ke Yang, Yue Qin, Jing Zhang, Jie Ma, Hui Dong
Summary: The study found that BRCA1 and TP53 gene variants increased the risk of lung cancer in Chinese population.
Review
Biochemistry & Molecular Biology
Aaron C. Tan, Nick Pavlakis
Summary: The management of advanced lung cancer has been transformed by the identification of targetable oncogenic driver alterations, including ALK gene rearrangements. ALK tyrosine kinase inhibitors have become the first-line treatment options for advanced ALK rearranged NSCLC. However, drug resistance remains a challenge, and the role of anti-angiogenic therapy in ALK rearranged NSCLC needs further exploration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Muyun Peng, Qikang Hu, Zeyu Wu, Bin Wang, Cheng Wang, Fenglei Yu
Summary: Ferroptosis is a highly regulated tumor suppressor process, and TP53 mutations can affect the sensitivity to ferroptosis. This study demonstrated that wild-type TP53 inhibits the expression of FOXM1 by maintaining mitochondrial function, thus affecting ferroptosis sensitivity. In mutant cells, this function is absent, resulting in overexpression of FOXM1 and resistance to ferroptosis.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Review
Immunology
Li-Chung Chiu, Shu-Min Lin, Yu-Lun Lo, Scott Chih-Hsi Kuo, Cheng-Ta Yang, Ping-Chih Hsu
Summary: Early-stage NSCLC patients face high risks of recurrence and death even after surgery, with limited improvements from traditional treatments like chemotherapy and radiation. Immunotherapies, including immune checkpoint inhibitors and cancer vaccination, have shown potential in improving survival rates and are being actively researched in clinical trials.
Article
Cell Biology
Hong-Wen Tang, Yanhui Hu, Chiao-Lin Chen, Baolong Xia, Jonathan Zirin, Min Yuan, John M. Asara, Leonard Rabinow, Norbert Perrimon
Article
Cell Biology
Wei Song, Serkan Kir, Shangyu Hong, Yanhui Hu, Xiaohui Wang, Richard Binari, Hong-Wen Tang, Verena Chung, Alexander S. Banks, Bruce Spiegelman, Norbert Perrimon
DEVELOPMENTAL CELL
(2019)
Article
Cell Biology
Chiwei Xu, Hong-Wen Tang, Ruei-Jiun Hung, Yanhui Hu, Xiaochun Ni, Benjamin E. Housden, Norbert Perrimon
Article
Multidisciplinary Sciences
Chiwei Xu, Brian Franklin, Hong-Wen Tang, Yannik Regimbald-Dumas, Yanhui Hu, Justine Ramos, Justin A. Bosch, Christians Villalta, Xi He, Norbert Perrimon
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Cell Biology
Anjali Bajpai, Taushif Ahmad Quazi, Hong-Wen Tang, Nishat Manzar, Virender Singh, Ashwani Thakur, Bushra Ateeq, Norbert Perrimon, Pradip Sinha
DISEASE MODELS & MECHANISMS
(2020)
Letter
Cell Biology
Lei Gu, Longfei Wang, Hao Chen, Jiaxu Hong, Zhangfei Shen, Abhinav Dhall, Taotao Lao, Chaozhong Liu, Zheng Wang, Yifan Xu, Hong-Wen Tang, Damayanti Chakraborty, Jiekai Chen, Zhihua Liu, Dragana Rogulja, Norbert Perrimon, Hao Wu, Yang Shi
Article
Multidisciplinary Sciences
Wenjun Wang, Jianshuang Li, Junyang Tan, Miaomiao Wang, Jing Yang, Zhi-Min Zhang, Chuanzhou Li, Alexei G. Basnakian, Hong-Wen Tang, Norbert Perrimon, Qinghua Zhou
Summary: ENDOG is released from mitochondria during starvation and promotes autophagy by enhancing its interaction with 14-3-3 gamma through phosphorylation, leading to mTOR pathway suppression and activation of DNA damage response through its endonuclease activity.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Hong-Wen Tang, Jui-Hsia Weng, Wen Xing Lee, Yanhui Hu, Lei Gu, Sungyun Cho, Gina Lee, Richard Binari, Cathleen Li, Min En Cheng, Ah-Ram Kim, Jun Xu, Zhangfei Shen, Chiwei Xu, John M. Asara, John Blenis, Norbert Perrimon
Summary: mTORC1 is a central regulator of cell growth and metabolism, playing critical roles in RNA biogenesis and processing. The study demonstrates that mTORC1 activates the chaperonin CCT complex to stabilize MTC, thereby increasing m(6)A levels and suppressing autophagy by degrading autophagy-related genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Yu-Hsuan Chen, Tzu-Yu Huang, Yu-Tung Lin, Shu-Yu Lin, Wen-Hsin Li, Hsiang-Jung Hsiao, Ruei-Liang Yan, Hong-Wen Tang, Zhao-Qing Shen, Guang-Chao Chen, Kuen-Phon Wu, Ting-Fen Tsai, Ruey-Hwa Chen
Summary: The study reveals that branched ubiquitination of VPS34 acts as a switch between UPS and autophagy, playing an important role in lipid metabolism in the liver.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Sungyun Cho, Gina Lee, Brian F. Pickering, Cholsoon Jang, Jin H. Park, Long He, Lavina Mathur, Seung-Soo Kim, Sunhee Jung, Hong-Wen Tang, Sebastien Monette, Joshua D. Rabinowitz, Norbert Perrimon, Samie R. Jaffrey, John Blenis
Summary: The study found that mTORC1 and its downstream kinase S6K enhance the translation of WTAP, affecting cellular metabolism and cancer progression. WTAP regulates MXD2 to impact the proliferation of mTORC1-activated cancer cells, revealing a mechanism by which mTORC1 stimulates oncogenic signaling through m(6)A RNA modification.
Article
Optics
Dongxia Li, Lizhen Zeng, Yuanli Wang, Hong-Wen Tang, Wen Xing Lee, Zhencheng Chen, Longhui Zhang, Yingchang Zou, Duan Xie, Fangrong Hu
Summary: We propose a method for diagnosing cirrhosis and hepatocellular carcinoma (HCC) using a terahertz metamaterial biosensor. The biosensor can measure the concentration of alpha-fetoprotein (AFP) in serum and shows a positive correlation with AFP levels in HCC patients.
Review
Biochemistry & Molecular Biology
Xujun Han, Kah Yong Goh, Wen Xing Lee, Sze Mun Choy, Hong-Wen Tang
Summary: The mechanistic target of rapamycin (mTOR) complex 1, mTORC1, plays critical roles in regulating cell growth, proliferation, and lifespan by integrating nutrient and growth factor signals. It has been reported as a central regulator of autophagy, modulating almost all aspects of the autophagic process. mTORC1 and autophagy are important for skeletal muscle function and are implicated in various muscle diseases. Targeting mTORC1 or autophagy pathways with inhibitors has shown potential in the treatment of muscle diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Chiwei Xu, Jun Xu, Hong-Wen Tang, Maria Ericsson, Jui-Hsia Weng, Jonathan DiRusso, Yanhui Hu, Wenzhe Ma, John M. Asara, Norbert Perrimon
Summary: Little is known about intracellular P-i metabolism and signaling in animal tissues. This study found that P-i starvation triggers the downregulation of the P-i transporter PXo and causes midgut hyperproliferation in Drosophila melanogaster. It was also discovered that PXo specifically marks non-canonical organelles called PXo bodies, which function as intracellular P-i reserves and undergo degradation during P-i starvation. Additionally, the study identified Cka as the mediator of PXo knockdown- or P-i starvation-induced hyperproliferation.
Article
Multidisciplinary Sciences
Hong-Wen Tang, Kerstin Spirohn, Yanhui Hu, Tong Hao, Istvan A. Kovacs, Yue Gao, Richard Binari, Donghui Yang-Zhou, Kenneth H. Wan, Joel S. Bader, Dawit Balcha, Wenting Bian, Benjamin W. Booth, Atina G. Cote, Steffi de Rouck, Alice Desbuleux, Kah Yong Goh, Dae-Kyum Kim, Jennifer J. Knapp, Wen Xing Lee, Irma Lemmens, Cathleen Li, Mian Li, Roujia Li, Hyobin Julianne Lim, Yifang Liu, Katja Luck, Dylan Markey, Carl Pollis, Sudharshan Rangarajan, Jonathan Rodiger, Sadie Schlabach, Yun Shen, Dayag Sheykhkarimli, Bridget TeeKing, Frederick P. Roth, Jan Tavernier, Michael A. Calderwood, David E. Hill, Susan E. Celniker, Marc Vidal, Norbert Perrimon, Stephanie E. Mohr
Summary: This study uses advanced methods to identify protein-protein interactions in Drosophila, generating widely useful physical and data resources for the identification of new components in pathways, complexes, and processes. The generation of reference maps of interactome networks provides a protein-centric approach to discover new components in existing pathways, complexes, and processes, which is helpful for genetic studies. The results include the FlyBi dataset and the DroRI reference interaction network, which provide a foundation for building new hypotheses about protein networks and function.
NATURE COMMUNICATIONS
(2023)