Article
Geriatrics & Gerontology
Chenxiao Lu, Changwu Tan, Hongfei Ouyang, Zhuohui Chen, Zhouyi Yan, Mengqi Zhang
Summary: Iron metabolism-related cell death mechanism called ferroptosis has become a topic of great interest among scientists. It interacts with other cell death pathways and plays a significant role in intracerebral hemorrhage (ICH). Understanding the role of ferroptosis in ICH opens new possibilities for future treatments and prevention of ICH and other intracerebral diseases.
Review
Immunology
Xu-Dong Zhang, Zhong-Yuan Liu, Mao-Sen Wang, Yu-Xiang Guo, Xiang-Kun Wang, Kai Luo, Shuai Huang, Ren-Feng Li
Summary: Regulation of cell mortality for disease treatment has been a focus of research, with the iron-dependent regulated cell death called Ferroptosis being extensively studied. Studies have shown that regulation of ferroptosis brings new treatment strategies for various diseases. Genes involved in iron and lipid metabolism can regulate ferroptosis by controlling iron overload and lipid peroxidation. Glutathione (GSH), the body's primary non-enzymatic antioxidant, also plays a crucial role in combating lipid peroxidation by assisting glutathione peroxidase 4 (GPX4). This review summarizes recent research on the mechanism of ferroptosis and comprehensively analyzes the regulation of ferroptosis through iron and lipid metabolism, as well as the metabolism of GPX4 and GSH.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Han Zhang, Enxiang Zhang, Hongbo Hu
Summary: Ferroptosis plays a critical role in the pathological progression of NAFLD and inhibiting ferroptosis may become a new therapeutic strategy for the treatment of NAFLD.
Review
Pharmacology & Pharmacy
Min Hong, Jiabing Rong, Xinran Tao, Yinchuan Xu
Summary: Ferroptosis is a type of programmed cell death characterized by iron-dependent lipid peroxidation, which differs from traditional cell death types in morphology, biochemistry, and genetics. It has been found to play a major role in cardiovascular diseases, and this review discusses its mechanisms and effects on the occurrence and development of such diseases, aiming to provide a new target for their prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Hui Zhao, Cheng Tang, Miao Wang, Hongfang Zhao, Yan Zhu
Summary: This review discusses the role and mechanism of ferroptosis in rheumatoid arthritis (RA), and explores its potential and challenges as a new therapeutic strategy, providing new targets for the prevention and treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Yufei Chen, Xueting Li, Siyuan Wang, Ran Miao, Jiuchang Zhong
Summary: Iron plays a crucial role in the cardiovascular system, and dysregulation of iron metabolism and ferroptosis are involved in the pathogenesis of various cardiovascular diseases. Iron chelators and lipophilic antioxidants have been shown to inhibit ferroptosis and lipid peroxidation in atherosclerosis, cardiomyopathy, and hypertension. Inhibition of ferroptosis can alleviate cardiac impairments and fibrosis in hypertension by enhancing GPX4 signaling. Novel small molecules targeting ferroptosis may be effective in the treatment of cardiovascular diseases. This article summarizes the regulatory roles and underlying mechanisms of iron metabolism dysregulation and ferroptosis in cardiovascular diseases and suggests targeting iron metabolism and ferroptosis as potential therapeutic strategies.
Review
Medicine, Research & Experimental
Tian-Liang Ma, Jing-Xian Chen, Peng Zhu, Chao-Bin Zhang, Yong Zhou, Jia-Xi Duan
Summary: Ferroptosis is an iron-dependent regulatory necrosis characterized by the accumulation of iron-dependent lipid peroxides in the plasma membrane and subsequent oxidative damage. It is mainly related to iron toxicity, lipid peroxidation, and mitochondrial dysfunction. Understanding the specific mechanism of ferroptosis and exploring strategies for its regulation have significant clinical implications.
Review
Geriatrics & Gerontology
Fuhai Feng, Shasha He, Xiaoling Li, Jiake He, Lianxiang Luo
Summary: This study aims to systematically elucidate the mechanisms via which mitochondria regulate ferroptosis and provide novel insights into mitochondrial functions. The study also presents a comprehensive overview of how mitochondria contribute to ferroptosis in different diseases. Understanding the involvement of mitochondria in ferroptosis could lead to more effective approaches for both basic cell biology studies and medical treatments.
Review
Biochemistry & Molecular Biology
Xiangnan Zheng, Cen Zhang
Summary: Ferroptosis, a novel form of regulated cell death, is characterized by intracellular iron and lipid peroxide accumulation. It is regulated by various factors such as iron metabolism, lipid metabolism, and antioxidant defense systems. Noncoding RNAs, including miRNAs, lncRNAs, and circRNAs, have been shown to modulate ferroptosis by directly or indirectly regulating ferroptosis-related genes or proteins. This review summarizes the mechanisms and regulations of ferroptosis and highlights the role of noncoding RNAs in regulating ferroptosis under different physiological and pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Ying Yao, Bin Wang, Yanbiao Jiang, Hong Guo, Yulan Li
Summary: Ferroptosis is a regulated form of cell death that is mainly associated with iron-driven lipid peroxidation damage. It is regulated by iron homeostasis, redox balance, lipid metabolism, glutathione metabolism, and various disease signaling pathways. The occurrence of Ferroptosis has both hidden dangers and advantages in ovary diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Geriatrics & Gerontology
Zhonghua Gao, Zhuoying Chen, Zhifan Xiong, Xiangjie Liu
Summary: Osteoporosis is a bone metabolic disease characterized by reduced bone mass and deterioration of bone tissue microarchitecture, leading to enhanced skeletal fragility and susceptibility to fracture. Abnormal iron metabolism, specifically iron overload, has been identified as an independent risk factor for osteoporosis. Moreover, the novel form of cell death known as ferroptosis, which involves iron overload and the accumulation of reactive oxygen species (ROS), is believed to play a key role in the occurrence and development of osteoporosis.
EXPERIMENTAL GERONTOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Jie Zhang, Caixia Guo
Summary: This review summarizes the molecular mechanisms, inducers or inhibitors of ferroptosis, and the current progress of ferroptosis in cardiovascular diseases, providing new insights and perspectives for the treatment of cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Oncology
Xue Wang, Ye Zhou, Junxia Min, Fudi Wang
Summary: Ferroptosis is an iron-dependent form of cell death caused by lipid peroxidation and has been implicated in the pathogenesis of various diseases involving multiple organs. Understanding the molecular mechanisms and regulatory pathways of ferroptosis could provide new strategies for disease management. Recent studies support ferroptosis as a potential target for the prevention and treatment of these diseases. This review summarizes the progress in ferroptosis research and its regulation in human disease, and discusses future directions in the targeting of ferroptosis.
FRONTIERS OF MEDICINE
(2023)
Review
Cell Biology
Xiangnan Zheng, Yuqiong Liang, Cen Zhang
Summary: Ferroptosis is a type of regulated cell death that is dependent on iron and involves the accumulation of intracellular lipid peroxides. It exhibits distinct features from other forms of regulated cell death in terms of morphology, biochemistry, and immunology. Ferroptosis is regulated by iron metabolism, lipid metabolism, antioxidant defense systems, and various signaling pathways. Hypoxia, which occurs in both physiological and pathological conditions, has been found to regulate ferroptosis in certain cell types and conditions through the activation of hypoxia-inducible factor (HIF) signaling and other mechanisms. This review provides an overview of the basic mechanisms and regulations of ferroptosis and hypoxia, as well as the regulation of ferroptosis by hypoxia in different physiological and pathological conditions, which may have implications for the treatment of various diseases.
Review
Cell Biology
Justin Chak Ting Cheung, Guangzheng Deng, Nathalie Wong, Yujuan Dong, Simon Siu Man Ng
Summary: Besides transcription, RNA molecules can be enzymatically modified to affect the biological functions of organisms, known as epitranscriptomics. The most widely studied modifications in epitranscriptomics are on adenosine (A), while modifications on other nucleotides are relatively fewer. It has been found that epitranscriptomic modifications also play a role in the signaling of ferroptosis, although the exact connection is still unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
