Article
Dermatology
Jun Jie Lim, Yi Ying Eliza Lim, Jun Yan Ng, Praneeth Malipeddi, Yu Ting Ng, Wei Yi Teo, Qi Yi Ambrose Wong, Sri Anusha Matta, Yang Yie Sio, Yi Ru Wong, Keng Foo Teh, Smyrna Moti Rawanan Shah, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew
Summary: This study aims to evaluate the association between dietary habits and AD, and finds that moderate dietary habits are associated with lower risk of AD. Additionally, the consumption of high-GI foods and low-GI foods are also found to be related to AD development.
Article
Public, Environmental & Occupational Health
Jun Jie Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew
Summary: This study analyzed the relationship between dietary patterns and atopic dermatitis (AD) in young Chinese adults from Singapore/Malaysia. The results showed that frequent adherence to plant-based foods was associated with reduced risks for AD exacerbation.
Review
Medicine, General & Internal
Andrea Chiricozzi, Martina Maurelli, Laura Calabrese, Ketty Peris, Giampiero Girolomoni
Summary: Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease that displays heterogeneity across different ethnicities. Genetic factors, such as Filaggrin (FLG) mutations, and immunological pathways, including Th2 hyperactivation and Th17-mediated signals, contribute to the differences in AD among racial groups. This heterogeneity has important therapeutic implications, as a tailored treatment strategy targeting specific immunologic pathways in each ethnic subgroup may be necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xin Yin, Cheryl Pui Yi Chan, Adeline Seow, Wai-Ping Yau, Wei Jie Seow
Summary: A case-control study conducted in Singapore found that family history is a significant risk factor for lung cancer in Singaporean Chinese women, especially among never-smokers. This highlights the importance of considering family history in assessing lung cancer risk, particularly in non-smoking populations.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Georgia Biazus Soares, Raquel Leao Orfali, Beatriz Lacerda Averbach, Gil Yosipovitch, Valeria Aoki
Summary: Latin America (LA), with its diverse population and social inequality, has a high prevalence of atopic dermatitis (AD). The literature review on AD in LA from 2004 to 2023 revealed variations in AD prevalence among different age groups and countries, as well as genetic and expression differences in filaggrin. AD patients in LA commonly experience erythema, pruritus, and dry skin, with a significant impact on their quality of life. However, there are challenges in diagnosing and managing AD in LA, including lack of universal diagnostic criteria, limited physician training, medication access barriers, and socioeconomic inequalities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Catherine Droitcourt, Ida Vittrup, Sandrine Kerbrat, Alexander Egeberg, Jacob P. Thyssen
Summary: The study found an increased risk of systemic infections among adults with hospital managed atopic dermatitis (AD), especially in terms of musculoskeletal, heart, respiratory tract, and skin infections.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Ophthalmology
Ying Wang, Qing Cun, Jun Li, Wei Shen, Wen-Yan Yang, Yi-Jin Tao, Zhi-Qiang Niu, Ying Zhang, Hua Zhong, Chen-Wei Pan
Summary: The prevalence of primary angle-closure glaucoma (PACG) in China is 0.7%. Ethnicity is a significant risk factor for PACG in Chinese adults. Age, intraocular pressure, axial length, and central corneal thickness are also associated with the prevalence of PACG.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Annalisa Astolfi, Francesca Cipriani, Daria Messelodi, Matilde De Luca, Valentina Indio, Costanza Di Chiara, Arianna Giannetti, Lorenza Ricci, Iria Neri, Annalisa Patrizi, Giampaolo Ricci, Andrea Pession
Summary: This study revealed that children with atopic dermatitis carrying FLG mutations are at higher risk of developing severe food allergies, such as anaphylaxis. Peanut and hazelnut were identified as high-risk foods for patients with FLG mutations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Ming Lei, Shalkar Adambekov, Robert P. Edwards, Renwei Wang, Jian-Min Yuan, Elora Kalix, Samia Lopa, Faina Linkov
Summary: This study explores the risk factors for endometrial cancer in the Singapore Chinese population and identifies obesity, later age at menarche, and later age at menopause as significant factors. The study also suggests that strategies developed for endometrial cancer prevention in Western populations may be applicable to the Singapore Chinese population due to similarities in risk factors.
ANNALS OF EPIDEMIOLOGY
(2022)
Review
Dermatology
E. Earp, Z. Tsianou, D. J. C. Grindlay, N. K. Rogers, B. Olabi
Summary: This review summarizes key findings from 18 systematic reviews published in 2019 on AE risk factors and prevention, highlighting the complex aetiology of AE.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Allergy
Jun Jie Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew
Summary: This study aimed to assess the association between dietary fats and the prevalence of atopic diseases. Through a questionnaire and skin prick test, it was found that a high-fat diet is closely related to an increased risk of allergic asthma and allergic rhinitis, as well as atopic dermatitis. Therefore, balancing the consumption of dietary fats and changing personal dietary habits may help reduce the risk of atopic diseases.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Allergy
Laura Maintz, Marie-Therese Schmitz, Nadine Herrmann, Svenja Mueller, Regina Havenith, Juliette Brauer, Claudio Rhyner, Anita Dreher, Eugen Bersuch, Danielle Fehr, Gertrud Hammel, Matthias Reiger, Daria Luschkova, Avidan Neumann, Claudia C. V. Lang, Ellen D. D. Renner, Peter Schmid-Grendelmeier, Claudia Traidl-Hoffmann, Cezmi A. A. Akdis, Roger Lauener, Marie-Charlotte Bruggen, Matthias Schmid, Thomas Bieber
Summary: This study aimed to compare the characteristics of adult-onset and childhood-onset AD. It found an association between adult-onset AD and smoking, and a negative correlation between conjunctivitis and atopic controls. Factors such as food allergy, maternal food allergy, palmar hyperlinearity, and academic background increased the odds of childhood-onset AD. These findings contribute to a better understanding of the risk factors for developing AD throughout life and emphasize the importance of non-smoking and physical activity in prevention.
Review
Allergy
Emily A. Croce, Moise L. Levy, Adewole S. Adamson, Elizabeth C. Matsui
Summary: Black people in the United States are more likely to experience atopic dermatitis (AD) compared to White people, while there is limited research on AD in the Latinx population. Genetic polymorphisms associated with AD risk and severity are less common among Black people, and socioeconomic, environmental, and health care factors have a significant influence on AD disparities among racial and ethnic minority populations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Dermatology
Yumiko Miyaji, Kiwako Yamamoto-Hanada, Tatsuki Fukuie, Masami Narita, Yukihiro Ohya
Summary: This study retrospectively analyzed the long-term prognosis of school children with atopic dermatitis treated with topical corticosteroids. The results showed that the dermatitis was well-controlled, but poor adherence was the biggest risk factor.
JOURNAL OF DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Yunchao Ou, Xiaoli Jiang, Huiwen Guan
Summary: The study found a significant association between the FokI rs2228570 polymorphism and the risk of atopic dermatitis, while no significant associations were found for TaqI, BsmI, and ApalI polymorphisms. Certain haplotypes were found to significantly increase the risk of AD. The effects of rs2228570 were more evident in certain subgroups, and the C allele of rs2228570 decreased relative mRNA expression.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Dermatology
Yee-How Say, Yang Yie Sio, Anna Hwee Sing Heng, Yu Ting Ng, Sri Anusha Matta, Sze Lei Pang, Keng Foo Teh, Yi Ru Wong, Smyrna Moti Rawanan Shah, Kavita Reginald, Fook Tim Chew
Summary: The study identified the signaling pathways between high glycemic index/glycemic load diet and acne vulgaris. By analyzing the genomic and transcriptomic data of acne cases and controls, several genes related to acne and dietary quality were discovered. Additionally, an intronic SNP in the GOLGA7B gene was found to be associated with acne. These findings provide a new model for the pathogenesis of acne related to high glycemic index/glycemic load diet.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Jun Yan Ng, Fook Tim Chew
Summary: Skin ageing is influenced by both genetic and lifestyle factors. This systematic review summarizes the current knowledge on skin ageing phenotypes and the associated genetic risk factors. The study identifies several promising SNPs and hub genes that are significantly associated with skin ageing. The findings suggest that pleiotropy plays a role in skin ageing and further research should focus on the contributions of genes on the chromosomal band 16q24.3.
SCIENTIFIC REPORTS
(2022)
Article
Allergy
Qi Yi Ambrose Wong, Jun Jie Lim, Jun Yan Ng, Praneeth Malipeddi, Wei Yi Teo, Yi Ying Eliza Lim, Yu Ting Ng, Yang Yie Sio, Sri Anusha Matta, Yi Ru Wong, Keng Foo Teh, Smyrna Moti Rawanan Shah, Kavita Reginald, Yee How Say, Fook Tim Chew
Summary: This study found an increase in AR prevalence over time in Asia. Factors such as male gender, parental history of allergic diseases increased the risk of AR, while factors like age, housing type, income level, pet ownership, sedentary lifestyle, and dietary habits were associated with AR. The study identified modifiable risk factors such as TV/computer usage and dietary habits that may impact AR manifestation, opening up new avenues for research in gene-environment interactions and AR management.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Allergy
Qi Yi Ambrose Wong, Jun Jie Lim, Jun Yan Ng, Praneeth Malipeddi, Ying Eliza Lim, Yang Yie Sio, Fook Tim Chew
Summary: The study found that the lifetime asthma prevalence rate among young Chinese adults in Singapore was 19.1%, while the current asthma prevalence rate was 6.3%. Parental history of asthma was identified as the most important risk factor, and increased consumption of certain foods and television/computer usage were also associated with asthma risk. Future research should consider the interaction between various factors to better understand the impact of environment and lifestyle on asthma.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Amr A. A. Abd El-Aal, Fairen A. Jayakumar, Kavita Reginald
Summary: Cryptides are bioactive peptides embedded in their parent proteins, which have multiple biological functions. Cationic cryptides, with their mechanism less likely to be affected by genetic mutations, could serve as modern drugs in infectious diseases and cancers. This review provides an overview of current understanding of cryptides, sustainable mining methods, and their potential applications in antimicrobial and anticancer therapy.
DRUG DISCOVERY TODAY
(2023)
Article
Allergy
Jun Jie Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew
Summary: This study aimed to assess the association between dietary fats and the prevalence of atopic diseases. Through a questionnaire and skin prick test, it was found that a high-fat diet is closely related to an increased risk of allergic asthma and allergic rhinitis, as well as atopic dermatitis. Therefore, balancing the consumption of dietary fats and changing personal dietary habits may help reduce the risk of atopic diseases.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Meeting Abstract
Respiratory System
J. J. Lim, P. Malipeddi, Y. Y. E. Lim, J. Y. Ng, W. Y. Teo, A. Q. Y. Wong, Y. R. Wong, K. F. Teh, S. M. Rawanan Shah, Y. Say, K. Reginald, S. A. Matta, Y. Y. Sio, F. T. Chew
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
Q. Y. A. Wong, J. J. Lim, J. Y. Ng, P. Malipeddi, W. Y. Teo, Y. Y. E. Lim, Y. R. Wong, K. F. Teh, S. M. Rawanan Shah, K. Reginald, Y. H. Say, S. A. Matta, Y. Y. Sio, F. T. Chew
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Hooi-Leng Ser, Joshua You-Jing Wong, Bey-Hing Goh, Kavita Reginald