Article
Neurosciences
Olga Laskov, Monika Klirova
Summary: This review found that the best outcomes were obtained after 20 sessions of high-frequency dTMS with OCD patients, where in addition to clinical improvement, patients showed amelioration of cognitive functions, specifically in cognitive control domains. However, studies on patients with depression appear to show inconsistent results, from cognitive improvement in open-label studies to no improvement versus sham dTMS in controlled trials.
NEUROSCIENCE LETTERS
(2021)
Review
Psychiatry
Yong Liu, Nannan Gu, Xinyi Cao, Yikang Zhu, Jijun Wang, Robert C. Smith, Chunbo Li
Summary: Transcranial electrical stimulation (tES) shows significant efficacy on working memory in schizophrenia in follow-up assessment, but not immediately after the last tES session. There was no significant difference in tolerability and dropouts between the active stimulation group and the sham stimulation group. Further large-scale RCTs with longer follow-ups are needed to confirm these findings.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Linda L. Carpenter, Scott T. Aaronson, Todd M. Hutton, Miriam Mina, Kenneth Pages, Sarah Verdoliva, W. Scott West, Harold A. Sackeim
Summary: The study compared the treatment outcomes of the Standard TMS protocol and the Dash protocol for major depressive disorder, and found that there was no significant difference in efficacy between the two protocols. Both protocols demonstrated strong antidepressant effects.
Article
Neurosciences
Victor M. Tang, Bernard Le Foll, Daniel M. Blumberger, Daphne Voineskos
Summary: This narrative review aims to highlight the interrelated aspects of the literature on repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) and alcohol use disorder (AUD). The review summarizes the available evidence on the effectiveness of rTMS for each condition, describes common symptom constructs that can be modulated by rTMS, and explores promising approaches in the personalization and optimization of rTMS for both AUD and MDD.
Article
Clinical Neurology
Keane Lim, Zixu Yang, Nur Amirah Abdul Rashid, Bhing Leet Tan, Justin Dauwels, Jimmy Lee
Summary: The study found that individuals with schizophrenia performed poorer in emotion recognition and theory of mind tasks compared to those with major depressive disorder and healthy controls. There was no statistically significant difference in social cognitive performance between individuals with major depressive disorder and healthy controls.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Yu-Ting Hu, Xi-Wen Hu, Jin-Fang Han, Jian-Feng Zhang, Ying-Ying Wang, Annemarie Wolff, Sara Tremblay, Dusan Hirjak, Zhong-Lin Tan, Georg Northoff
Summary: This study compared the therapeutic efficacy of rTMS at the left motor cortex (lMC) and left dorsolateral prefrontal cortex (lDLPFC) in MDD patients. The results showed no significant difference in treatment outcomes and tolerability between the two groups. The findings suggest that lMC can be a potential and easily accessible rTMS target.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Medicine, General & Internal
Kristoffer Johansson, Mats Adler, Ullvi Bave, Carl-Johan Ekman, Johan Lundberg
Summary: This study investigated the effects of different doses of magnetic pulses on MDD patients treated with rTMS, finding that 4000 pulses had the most significant effect in the initial phase of treatment. After 4 weeks, all three treatment groups showed significant improvements in depressive symptoms, with no serious adverse events reported.
Article
Psychology, Clinical
Scott A. Wilke, Crystal L. Johnson, Juliana Corlier, Katharine G. Marder, Andrew C. Wilson, Christopher M. Pleman, Andrew F. Leuchter
Summary: MDD patients taking psychostimulant medication show greater clinical improvement during rTMS treatment, particularly in sleep and mood/cognition. There are no significant differences among different drug categories, and the clinical efficacy of some medications may be dose-dependent.
DEPRESSION AND ANXIETY
(2022)
Article
Psychiatry
Maxime Richard, Clemence Noiseux, Veronique Desbeaumes Jodoin, Daniel M. Blumberger, Jack Sheen, Farrokh Mansouri, Laurent Elkrief, Christophe Longpre-Poirier, Paul Lesperance, Jean-Philippe Miron
Summary: This study assessed the safety and effectiveness of a prolonged iTBS protocol using 1800 pulses for the treatment of major depressive disorder. The results showed that a small number of participants achieved partial response, but the overall effectiveness was still uncertain. Further research should focus on determining the optimal treatment parameters.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Adrienn Holczer, Viola Luca Nemeth, Teodora Vekony, Krisztian Kocsis, Andras Kiraly, Zsigmond Tamas Kincses, Laszlo Vecsei, Peter Klivenyi, Anita Must
Summary: The study showed that active TBS had a moderate effect in improving depressive symptoms compared to sham stimulation, with no effects on attention and working memory detected. Further research is needed to investigate the effects of TBS on psychomotor processing speed.
Article
Clinical Neurology
Yu-Ting Hu, Xi-Wen Hu, Jin-Fang Han, Jian-Feng Zhang, Ying-Ying Wang, Annemarie Wolff, Sara Tremblay, Zhong-Lin Tan, Georg Northoff
Summary: This study found that childhood trauma negatively affects the subjective perception of rTMS treatment outcomes in female MDD patients, while not affecting male patients.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Review
Clinical Neurology
Domenico Sciortino, Alessandro Pigoni, Giuseppe Delvecchio, Eleonora Maggioni, Giandomenico Schiena, Paolo Brambilla
Summary: The results suggest that repeated Transcranial Magnetic Stimulation (rTMS) may improve cognitive symptoms in patients with Bipolar Disorder (BD) but shows limited efficacy in patients with Schizophrenia (SCZ). However, the conclusions are limited by the use of different rTMS protocols in the studies.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Jeffrey D. Voigt, Andrew F. Leuchter, Linda L. Carpenter
Summary: Through analyzing data from multiple randomized controlled trials, this study found that theta burst stimulation (TBS) is superior to sham treatment in treating major depressive disorder, and is noninferior to standard rTMS therapy (high frequency stimulation over the left prefrontal cortex). These results support the continued development of TBS as a treatment for depression.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Qingxia Yang, Qiaowen Xing, Qingfang Yang, Yaguo Gong
Summary: Schizophrenia, bipolar disorder, and major depressive disorder are the most common psychiatric disorders. Diagnosing these disorders is difficult due to overlaps in genetic epidemiology and molecular genetics. This study used transcriptomic data to identify key genes and construct a classification model for differentiating these disorders. The model showed potential for improving the diagnoses of these psychiatric disorders.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Psychiatry
Wei Zheng, Dong-Bin Cai, Sha Nie, Jian-Hua Chen, Xing-Bing Huang, Stephan Goerigk, Andre Russowsky Brunoni, Wei Zheng
Summary: This meta-analysis examined the therapeutic effects and tolerability of transcranial alternating current stimulation (tACS) for major depressive disorder (MDD) patients. The results showed that tACS had a modestly effective and safe impact on improving depressive symptoms in MDD patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
