Review
Pharmacology & Pharmacy
Mingtai Chen, Ying Xie, Shenglan Gong, Yunqiao Wang, Hao Yu, Tianran Zhou, Furong Huang, Xin Guo, Huanhuan Zhang, Ruolan Huang, Zhiyi Han, Yufeng Xing, Qiang Liu, Guangdong Tong, Hua Zhou
Summary: NASH is a common chronic liver disease in clinical practice with no officially approved pharmacological therapy. Traditional Chinese medicine has been proven beneficial in treating NASH in multiple studies, providing a potential therapy for this condition.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiwei Yuan, Lu Li, Ying Zhang, Rong Ai, Dongdong Li, Yao Dou, Mengmeng Hou, Dandan Zhao, Suxian Zhao, Yuemin Nan
Summary: This study found that heme oxygenase 1 (HO-1) plays an important role in ferroptosis in nonalcoholic steatohepatitis (NASH). HO-1 deficiency exacerbates the pathological manifestations of NASH, while HO-1 overexpression alleviates NASH progression. Mechanistic studies have shown that the NF-κB signaling pathway is associated with ferroptosis in NASH.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Agriculture, Multidisciplinary
Yinhua Ni, Yating Hu, Xiaoyi Lou, Nianke Rong, Fang Liu, Congrong Yang, Aqian Zheng, Song Yang, Jianfeng Bao, Zhengwei Fu
Summary: Spermidine may improve NASH partly through regulating the THRSP signaling pathway and gut microbiota-mediated bile acid metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Yang Xie, Feng Shen, Yafang He, Canjie Guo, Ruixu Yang, Haixia Cao, Qin Pan, Jiangao Fan
Summary: The effect and mechanism of gamma-muricholic acid (gamma-MCA) in improving nonalcoholic steatohepatitis (NASH) were investigated. It was found that gamma-MCA targeted the FXR/SHP/LXR alpha/FASN signaling pathway to inhibit steatosis-induced peroxidative injury and ameliorate NASH. The treatment with gamma-MCA resulted in decreases in hepatic steatosis, lipid peroxidation, peroxidative injury, hepatocyte apoptosis, and NAFLD activity score (NAS).
Article
Gastroenterology & Hepatology
Lindsey Kennedy, Vik Meadows, Amelia Sybenga, Jennifer Demieville, Lixian Chen, Laura Hargrove, Burcin Ekser, Wasim Dar, Ludovica Ceci, Debjyoti Kundu, Konstantina Kyritsi, Linh Pham, Tianhao Zhou, Shannon Glaser, Fanyin Meng, Gianfranco Alpini, Heather Francis
Summary: The study found that mast cells promote the progression of NAFLD/NASH and inhibiting mast cell activation may be a potential therapeutic strategy for NAFLD/NASH by controlling the miR-144-3p/ALDH1A3 signaling pathway.
Article
Pharmacology & Pharmacy
Zhan-Ming Li, Chao-Yue Kong, Yu-Qin Mao, Hui-Ling Chen, Shi-Long Zhang, Jia-Ting Huang, Jin-Qing Yao, Pei-Ran Cai, Nuo Xie, Bing Han, Li-Shun Wang
Summary: ALDH2 plays a critical role in the development of nonalcoholic steatohepatitis (NASH) through modulation of gut microbiota and bile acid. Supplementation of Lactobacillus or lithocholic acid (LCA) could be a promising therapeutic approach for treating NASH exacerbated by ALDH2 deficiency.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Toxicology
Hana Lastuvkova, Zuzana Nova, Milos Hroch, Fatemeh Alaei Faradonbeh, Jolana Schreiberova, Jaroslav Mokry, Hana Faistova, Alzbeta Stefela, Jan Dusek, Otto Kucera, Radomir Hyspler, Ester Dohnalkova, Rachel L. Bayer, Petra Hirsova, Petr Pavek, Stanislav Micuda
Summary: In this study, the effect of carvedilol on bile formation and bile acid turnover in mice with either a chow diet or a NASH-inducing diet was investigated. Carvedilol was found to improve liver pathology in NASH mice without worsening bile acid accumulation, suggesting potential beneficial effects of carvedilol in patients at high risk for developing NASH.
TOXICOLOGICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Wenjing Xu, Changting Cui, Chunmei Cui, Zhenzhen Chen, Haizeng Zhang, Qinghua Cui, Guoheng Xu, Jianglin Fan, Yu Han, Liangjie Tang, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng, Liming Yang, Jun Cai, Bin Geng
Summary: This study found that CSE protein expression is significantly downregulated in the liver of NAFLD patients, and the CSE/H2S pathway is also downregulated. Feeding an HFD to CSE knockout mice resulted in increased hepatic lipid deposition and insulin resistance, which could be attenuated by H2S donor treatment. Furthermore, CSE/H2S was found to promote sulfhydration modification of FXR, enhancing its activity in regulating target gene expression.
Review
Endocrinology & Metabolism
Hui Xiang, Dating Sun, Xin Liu, Zhi-Gang She, Yonghong Chen
Summary: This article mainly summarizes the important impact of intestinal microbiota and its metabolites on the development of NASH. A balanced intestinal microbiota contributes to liver homeostasis, while an imbalanced microbiota may lead to NASH. Additionally, recent clinical trials and animal studies on treating NASH by regulating the intestinal microbiota through prebiotics, probiotics, synbiotics, and FMT are briefly discussed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yingwei Zhu, Han Zhao, Jian Lu, Kai Lin, Jingbin Ni, Gaojue Wu, Hong Tang
Summary: The study found that caspase-11 was upregulated in the livers of NASH mice. Caspase-11-deficient mice treated with MCD showed significantly reduced liver injury, fibrosis, and inflammation, as well as inhibited activation of gasdermin D and interleukin-1 beta. Overexpression of caspase-11 promoted steatohepatitis, indicating that caspase-11-mediated hepatocytic pyroptosis promotes the progression of NASH.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrea Barrientos-Riosalido, Monica Real, Laia Bertran, Carmen Aguilar, Salome Martinez, David Parada, Margarita Vives, Fatima Sabench, David Riesco, Daniel Del Castillo, Cristobal Richart, Teresa Auguet
Summary: This study analyzed the expression of ATG7 gene in obesity-associated NAFLD and found that ATG7 was highly expressed in NASH patients. ATG7 may play an important role in the pathogenesis of NAFLD, especially in NASH, possibly having a protective effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Jagpreet Chhatwal, Ozden O. Dalgic, Wanyi Chen, Sumeyye Samur, Emily D. Bethea, Jade Xiao, Chin Hur, Kathleen E. Corey, Rohit Loomba
Summary: This decision analytic model study simulated stage-specific long-term outcomes, including liver- and non-liver-related mortality in patients with nonalcoholic fatty liver disease (NAFLD). Depending on age and fibrosis stage, non-liver-related mortality was higher than liver-related mortality in patients with NAFLD.
Article
Gastroenterology & Hepatology
Maryam Hashemian, Shahin Merat, Hossein Poustchi, Elham Jafari, Amir-Reza Radmard, Farin Kamangar, Neal Freedman, Azita Hekmatdoost, Mahdi Sheikh, Paolo Boffetta, Rashmi Sinha, Sanford M. Dawsey, Christian C. Abnet, Reza Malekzadeh, Arash Etemadi
Summary: In a population with low consumption of red meat, individuals with the highest intake of red meat were at increased risk of NAFLD. Additionally, this study is the first to demonstrate an association between organ meat consumption and NAFLD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Hua-Chien Wu, Yin-Ru Hsieh, Weu Wang, Ching-Wen Chang, I-Wei Chang, Chi-Long Chen, Chun-Chao Chang, Chia-Hsuan Chang, Wei-Yu Kao, Shih-Yi Huang
Summary: This study investigated the differences in lipidomic profile features between mild and significant liver fibrosis cases in patients with morbid obesity and NASH. The results showed that the concentrations of triglycerides, cholesterol esters, phosphatidylcholine, phosphatidic acid, phosphatidylinositol, phosphatidylglycerol, and sphingomyelin were significantly lower in patients with significant fibrosis compared to those with mild fibrosis. However, the concentration of phosphatidylcholine was relatively higher in patients with stage 2-4 fibrosis. Moreover, predictive models incorporating specific lipid components showed a potential correlation between NASH fibrosis stages and liver lipid accumulation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jose Ignacio Martinez-Montoro, Mohammad Shafi Kuchay, Andres Balaguer-Roman, Maria Antonia Martinez-Sanchez, Maria Dolores Frutos, Jose Carlos Fernandez-Garcia, Bruno Ramos-Molina
Summary: This review summarizes the relationship between the severity of nonalcoholic fatty liver disease (NAFLD) and gut microbiota, as well as the role of gut microbiome and related metabolites in NAFLD improvement after bariatric surgery (BS).
Article
Physics, Nuclear
Zi-Long Li, Xing-Yue Tan, Zhu-Feng Zhang, Zhen-Yang Wang, Xin-Heng Guo
Summary: In this study, we systematically investigated systems with two pseudoscalar mesons and obtained some conclusions by numerically solving the Bethe-Salpeter equation.
Article
Oncology
Xuewang Li, Lei Huang, Liangliang Kong, Yong Su, Huimin Zhou, Pengmin Ji, Ran Sun, Chao Wang, Weiping Li, Weizu Li
Summary: This study suggests that Rg1 treatment can improve cognitive impairments and neuronal injuries in an AD mouse model, as well as reduce A beta deposition. Additionally, Rg1 inhibits NLRP1 inflammasome and improves autophagy dysfunction. These findings indicate that Rg1 may be a potential therapeutic agent for delaying AD.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Engineering, Manufacturing
Xiaoqing Zhang, Wei Yuan, Honglin Huang, Ming Xu, Yu Chen, Bote Zhao, Xinrui Ding, Shiwei Zhang, Yong Tang, Longsheng Lu
Summary: A self-assembly strategy is proposed to fabricate a multifunctional layer on the separator of lithium-sulfur batteries, which can improve sulfur utilization and electrochemical reaction kinetics.
INTERNATIONAL JOURNAL OF EXTREME MANUFACTURING
(2023)
Article
Engineering, Aerospace
Lei Zu, Hui Xu, Shijun Chen, Jingxuan He, Qian Zhang, Ping Ren, Guiming Zhang, Liqiang Wang, Qiaoguo Wu, Jianhui Fu
Summary: This paper proposes a multi-objective optimization method for different dome reinforcement methods of a filament-wound solid rocket motor composite case. The Radial Basis Function (RBF) model is used to improve the optimization efficiency. Progressive damage of the composite case is considered, and the simulation results are validated by hydraulic burst tests. The optimal reinforcement method is found to be variable-angle dome reinforcement, which can ensure continuous changing of the reinforcement angle and decrease the mass of composite materials.
CHINESE JOURNAL OF AERONAUTICS
(2023)
Article
Engineering, Biomedical
Jichun Yang, Chong Zhang, Xiaohui Chen, Daijun Zhou, Zixin Sun, Ruyan Niu, Ying Zhu, Hengyi Chen, Liu Wang, Yi Chen, Yuhan Wang, Yunqian Fu, Ningyu Ma, Jianjun Li, Yang Luo
Summary: In this study, an ultra-efficient radiotherapy strategy was reported using extracellular vesicles encapsulating hollow MnO2 loaded with metformin. This strategy showed significant enhancement of radiotherapy effect by regulating tumor microenvironment and improving cellular uptake. Moreover, it activated innate immune response and demonstrated promising results in inhibiting distal metastasis and in-situ recurrence.
Article
Plant Sciences
Huiming Huang, Liangguang Yue, Fayu Deng, Xiaoyu Wang, Ning Wang, Hu Chen, Huayue Li
Summary: The integration of NMR-metabolomic and genomic analyses allows for enhanced identification of structural properties and biosynthetic information in natural products. In this study, NMR-based metabolomic profiling and genome mining were employed to isolate and determine the structures of two new natural products from Streptomyces sp. S063. The cytotoxicity evaluation demonstrated moderate growth inhibition against several human cancer cells.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Optics
Zhiyuan Yin, Wei Liu, Dianchang Song, Yongze Liang, Xue Zhou, Xuenan Zhang, Xin Yan, Yu Qin, Yichun Shen, Zelin Zhang, Tonglei Cheng
Summary: In this paper, a transmissive fluorescent temperature sensor (TFTS) based on Er3+/Yb3+/Mo6+ tri-doped tellurite fiber is fabricated, which offers compactness, simplicity, corrosion resistance, high stability, and anti-electromagnetic interference. The addition of Mo6+ ions enhances the up-conversion fluorescence emission efficiency of Er3+ ions, resulting in improved signal-to-noise ratio. The sensor demonstrates good stability and a maximum relative sensitivity of 0.01068 K-1 at 274 K, making it suitable for real-time thermal monitoring of motors.
Article
Acoustics
Buddhi Wickramasinghe, Eliathamby Ambikairajah, Vidhyasaharan Sethu, Julien Epps, Haizhou Li, Ting Dang
Summary: This paper proposes a novel approach to protect automatic speaker verification systems against replay spoofing attacks. By using an adaptive filter bank and a deep neural network-based controller as the front-end, and jointly training with a neural network back-end, the effectiveness of the proposed framework is demonstrated in spoofing attack detection.
SPEECH COMMUNICATION
(2023)
Article
Health Care Sciences & Services
Xiaofeng Zhang, Jiaqi Zhang, Yongzhi Cai, Yue Li, Shiyun Qin, Jingtao Li, Decai Zeng, Tongtong Huang, Liu Liu Huang, Yanfen Zhong, Lihui Wei, Ji Wu
Summary: This study found that preoperative parameters of global left ventricular long-axis strain (LVGLS) and mechanical discretization (MD) were associated with postoperative adverse left ventricular remodeling in patients with rheumatic heart disease. The LVGLS and MD values were lower or higher in the poorly reconstructed group compared to the healthy control group and the non-poorly reconstructed group. LVGLS and MD can be used as markers for predicting adverse LVR.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yumeng Sun, Haiyang Xu, Lei Kou, Shuo Wang, Zhenjia Wang, Wei Yu
Summary: This study investigates the association between plaque imaging findings and the stent expansion rate (SER) of the carotid artery. The results suggest that calcified plaques are associated with SER, with calcification circumference being correlated with SER in open-cell stents and calcification circumference, calcification area, and calcification location being related to SER in closed-cell stents. These findings provide important considerations for clinicians when choosing carotid artery stents.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Ye Xu, Jingwen Wang, Tao Zhang, Zhihao Chen, Kaihui Xian, Zi Li, Yang-Hui Luo, Long Ye, Xiaotao Hao, Huifeng Yao, Jianhui Hou
Summary: A new alternating copolymer donor was designed for all-polymer solar cells, and the addition of a small-molecule acceptor improved the power conversion efficiency and blend morphology.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
Article
Optics
Na Li, Sha Wu, Xinyi Shen, Pingyuan He, Ping He, Linbo Guan, Huai Bai, Yao Xiao
Summary: In this study, carbon dots (CDs) were prepared using hydrothermal method and then encapsulated in polymethyl methacrylate (PMMA) nanoparticles through suspension polymerization. The resulting CD/PMMA nanocomposite showed reduced aggregation-induced quenching and higher quantum yield compared to conventional CD/PMMA composites.
JOURNAL OF LUMINESCENCE
(2024)
Article
History
Sergio Bravo Sanchez
Summary: The absence of Emperor Charles V in Castile from 1528 onwards led to the rise of his wife Isabel of Portugal as the head of the government, creating opportunities for the high aristocracy to challenge royal authority. The matrimonial dispute between the IV Count of Uruena and the ladies Maria Enriquez and Maria de la Cueva, lasting for almost five years, resulted in a confrontation between lineages with significant political implications.
TIEMPOS MODERNOS-REVISTA ELECTRONICA DE HISTORIA MODERNA
(2023)
Proceedings Paper
Computer Science, Information Systems
Huanjing Wang, Qianxin Liang, John T. Hancock, Taghi M. Khoshgoftaar
Summary: This research aims to improve the accuracy of credit card fraud detection by using ensemble feature ranking methods. Experimental results show that the ensemble of feature selection and all features performs well in terms of performance, and XGBoost outperforms CatBoost in terms of AUPRC.
2023 IEEE 24TH INTERNATIONAL CONFERENCE ON INFORMATION REUSE AND INTEGRATION FOR DATA SCIENCE, IRI
(2023)
Article
Computer Science, Artificial Intelligence
Huanjie Tao
Summary: This paper proposes a new method for smoke recognition in forest fires, which includes enhanced deformable convolution, multi-directional feature interaction, and a new loss term based on generative adversarial learning. Experimental results demonstrate that the model accurately estimates smoke pixels and outperforms existing smoke recognition methods.
EXPERT SYSTEMS WITH APPLICATIONS
(2024)
