期刊
JOURNAL OF PROTEOME RESEARCH
卷 15, 期 2, 页码 554-562出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jproteome.5b00951
关键词
metabolomics; joint inflammation; diagnosis; prognosis; arthritis; rheumatoid arthritis
资金
- Helmholtz Zentrum Munchen - German Research Center for Environmental Health by German Federal Ministry of Education and Research (BMBF)
- State of Bavaria
- BMBF [0315494A]
- German Federal Ministry of Education and Research (BMBF)
- 'Biomedical Research Program' funds at Weill Cornell Medical College in Qatar - Qatar Foundation
This study aims at identifying metabolites that significantly associate with self reported joint symptoms (diagnostic) and metabolites that can predict the change from a symptom-free status to the development of self-reported joint symptoms after a 7 years period (prognostic). More than 300 metabolites were analyzed for 2246 subjects from the longitudinal study of the KORA (Cooperative Health Research in the Region of Augsburg, Germany), specifically the fourth survey S4 and its 7-year follow-up study F4. Two types of self-reported symptoms, chronic joint inflammation and worn out joints, were used for the analyses. Diagnostic analysis identified dysregulated metabolites in cases with symptoms compared with controls. Prognostic analysis identified metabolites that differentiate subjects in S4 who remained symptom-free after 7 years (F4) from those who developed any combination of symptoms. 48 metabolites were identified as nominally significantly (p < 0.05) associated with the self-reported symptoms in the diagnostic analysis, among which steroids show Bonferroni significance. 45 metabolites were identified as nominally significantly associated with developing symptoms after 7 years, among which hippurate showed Bonferroni significance. We show that metabolic profiles of self-reported joint symptoms are in line with metabolites known to associate with various forms of arthritis and suggest that future studies may benefit from that by investigating the possible use of self-reporting/questionnaire along with metabolic markers for the early referral of patients for further diagnostic workup and treatment of arthritis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据