期刊
CELL CYCLE
卷 14, 期 16, 页码 2648-2654出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2015.1064567
关键词
Cyclin B3; oocyte; meiosis; SAC; anaphase initiation
类别
资金
- National Basic Research Program of China [2012CB944404, 2011CB944501]
- National Natural Science Foundation of China [31371451]
Cyclin B3 is a relatively new member of the cyclin family whose functions are little known. We found that depletion of cyclin B3 inhibited metaphase-anaphase transition as indicated by a well-sustained MI spindle and cyclin B1 expression in meiotic oocytes after extended culture. This effect was independent of spindle assembly checkpoint activity, since both Bub3 and BubR1 signals were not observed at kinetochores in MI-arrested cells. The metaphase I arrest was not rescued by either Mad2 knockdown or cdc20 overexpression, but it was rescued by securin RNAi. We conclude that cyclin B3 controls the metaphase-anaphase transition by activating APC/C-cdc20 in meiotic oocytes, a process that does not rely on SAC activity.
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