期刊
CELL CYCLE
卷 14, 期 21, 页码 3379-3388出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2015.1090068
关键词
angiogenesis; cell cycle; endothelial cell; metabolism; quiescence
类别
资金
- Research Foundation Flanders (FWO)
- Agency for Innovation by Science and Technology (IWT)
- Belgian Science Policy [IUAP7/03]
- Flemish Government
- FWO
- Foundation Leducq Transatlantic Network (ARTEMIS)
- Foundation against Cancer, an European Research Council (ERC) Advanced Research Grant (EU) [ERC269073]
- AXA
- Foundation against Cancer
Cell division is a metabolically demanding process, requiring the production of large amounts of energy and biomass. Not surprisingly therefore, a cell's decision to initiate division is co-determined by its metabolic status and the availability of nutrients. Emerging evidence reveals that metabolism is not only undergoing substantial changes during the cell cycle, but it is becoming equally clear that metabolism regulates cell cycle progression. Here, we overview the emerging role of those metabolic pathways that have been best characterized to change during or influence cell cycle progression. We then studied how Notch signaling, a key angiogenic pathway that inhibits endothelial cell (EC) proliferation, controls EC metabolism (glycolysis) during the cell cycle.
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