Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alström syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period

Monogenic obesity syndromes provide insights into the hypothalamic regulation of appetite and associated behaviors

(2022) I. Sadaf Farooqi   BIOLOGICAL PSYCHIATRY

Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons

(2021) Liheng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The morbid genome of ciliopathies: an update

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Effect of setmelanotide, a melanocortin‐4 receptor agonist, on obesity in Bardet‐Biedl syndrome

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Bardet‐Biedl syndrome: Weight patterns and genetics in a rare obesity syndrome

(2020) Jeremy Pomeroy et al.   Pediatric Obesity

Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials

(2020) Karine Clément et al.   Lancet Diabetes & Endocrinology

The BBSome in POMC and AgRP Neurons is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors

(2019) Deng-Fu Guo et al.   DIABETES

Clinical, molecular genetics and therapeutic aspects of syndromic obesity

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MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

(2018) Karine Clément et al.   NATURE MEDICINE

Managing Bardet–Biedl Syndrome—Now and in the Future

(2018) Elizabeth Forsythe et al.   Frontiers in Pediatrics

Screening for Obesity in Children and Adolescents

(2017) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Copy-Number Variation Contributes to the Mutational Load of Bardet-Biedl Syndrome

(2016) Anna Lindstrand et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hyperphagia: Current concepts and future directions proceedings of the 2nd international conference on hyperphagia

(2014) Steven B. Heymsfield et al.   Obesity

Clinical Trials in Rare Disease

(2013) Erika F. Augustine et al.   JOURNAL OF CHILD NEUROLOGY

Bardet–Biedl syndrome

(2012) Elizabeth Forsythe et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Patients with Bardet-Biedl Syndrome Have Hyperleptinemia Suggestive of Leptin Resistance

(2011) Penelope P. Feuillan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Alström syndrome: insights into the pathogenesis of metabolic disorders

(2010) Dorothée Girard et al.   Nature Reviews Endocrinology