期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2022.1074205
关键词
stroke; post-stroke pain; exercise; analgesic effect; analgesic mechanism
资金
- Shanghai Frontiers Science Research Base of Exercise and Metabolic Health
- Talent Development Fund of Shanghai Municipal [21MC1930200]
- Shanghai Clinical Research Center for Rehabilitation Medicine [11DZ2261100]
- Shanghai Key Lab of Human Performance (Shanghai University of Sport) [2021081]
This article reviews the effectiveness and mechanisms of exercise interventions for post-stroke pain (PSP). Exercise training not only improves physical function but also effectively reduces pain intensity and attenuates the behavioral response to pain. Additionally, exercise therapy can improve brain function and exert specific analgesic effects. However, further research is needed to investigate the sustainable benefits of exercise interventions for PSP.
One of the common negative effects of a stroke that seriously lowers patients' quality of life is post-stroke pain (PSP). Thus, exercise in PSP management has become a hot research topic. The main advantages of exercise therapy are affordability and ease of acceptance by patients compared to other treatment methods. Therefore, this article reviews the effectiveness and possible mechanisms of exercise interventions for PSP. Exercise training for patients with PSP not only improves physical function but also effectively reduces pain intensity and attenuates the behavioral response to pain. In addition, exercise therapy can improve brain function and modulate levels of pro-inflammatory and neurotrophic factors to exert specific analgesic effects. Potential mechanisms for exercise intervention include modulation of synaptic plasticity in the anterior cingulate gyrus, modulation of endogenous opioids in vivo, reversal of brain-derived neurotrophic factor overexpression, inhibition of purinergic receptor (P2X4R, P2X7R) expression, and inhibition of microglia activation. However, current research on exercise for PSP remains limited, and the sustainable benefits of exercise interventions for PSP need to be further investigated.
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