Exploring the biophysical evidence that mammalian two-pore channels are NAADP-activated calcium-permeable channels

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore

(2015) Sean M. Davidson et al.   CARDIOVASCULAR RESEARCH

Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

(2015) M. Ruas et al.   EMBO JOURNAL

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

Function and dysfunction of two-pore channels

(2015) Sandip Patel   Science Signaling

The phosphoinositide PI(3,5)P2 mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells

(2014) Anna Boccaccio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

(2014) A. Jha et al.   EMBO JOURNAL

Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition

(2014) L. N. Hockey et al.   JOURNAL OF CELL SCIENCE

The voltage-gated sodium channel TPC1 confers endolysosomal excitability

(2014) Chunlei Cang et al.   Nature Chemical Biology

Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+

(2014) S. J. Pitt et al.   Science Signaling

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability

(2014) Chunlei Cang et al.   Nature Communications

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Is a Second Messenger in Muscarinic Receptor-induced Contraction of Guinea Pig Trachea

(2013) Parvinder K. Aley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH

(2013) Yingying Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing

(2012) Lianne C. Davis et al.   CURRENT BIOLOGY

Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1

(2012) Volodymyr Rybalchenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 is a Novel NAADP-Sensitive Intracellular Ca2+-Release Channel with Unique Gating Characteristics

(2011) Samantha J. Pitt et al.   BIOPHYSICAL JOURNAL

Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels

(2011) Soichiro Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Regulates Autophagy in Cultured Astrocytes

(2011) Gustavo J. S. Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells

(2011) Yaping Lin-Moshier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg

(2011) Timothy F. Walseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In situ Measurement of the Electrical Potential Across the Lysosomal Membrane Using FRET

(2011) Mirkka Koivusalo et al.   TRAFFIC

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

(2010) Michael X. Zhu et al.   FEBS LETTERS

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

(2010) Samantha J. Pitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+Currents in Isolated Lysosomes

(2010) Michael Schieder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Topology of NAADP-sensitive Two-pore Channels and Their Regulation by N-linked Glycosylation

(2010) Robert Hooper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels

(2010) P. K. Aley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analogues of the Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Antagonist Ned-19 Indicate Two Binding Sites on the NAADP Receptor

(2009) Daniel Rosen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY