Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

Unipotent,Atoh1+progenitors maintain the Merkel cell population in embryonic and adult mice

(2015) Margaret C. Wright et al.   JOURNAL OF CELL BIOLOGY

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons

(2015) Yanmei Qi et al.   Nature Communications

Merkel Cells Transduce and Encode Tactile Stimuli to Drive Aβ-Afferent Impulses

(2014) Ryo Ikeda et al.   CELL

Transient receptor potential ankyrin 1 (TRPA1) channel activation by the thienopyridine-type drugs ticlopidine, clopidogrel, and prasugrel

(2014) Anja Schulze et al.   CELL CALCIUM

Functional Role for Piezo1 in Stretch-evoked Ca2+Influx and ATP Release in Urothelial Cell Cultures

(2014) Tatsuya Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

(2014) Justin D Crane et al.   NATURE MEDICINE

PIEZO2 is required for mechanotransduction in human stem cell–derived touch receptors

(2014) Katrin Schrenk-Siemens et al.   NATURE NEUROSCIENCE

Piezo2 channel conductance and localization domains in Merkel cells of rat whisker hair follicles

(2014) Ryo Ikeda et al.   NEUROSCIENCE LETTERS

Mechanotransduction in epidermal Merkel cells

(2014) Masashi Nakatani et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility

(2013) Gillian Roach et al.   DEVELOPMENTAL BIOLOGY

Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain

(2013) Ryosuke Kojima et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Distinct Cellular Origins for Serotonin-Expressing and Enterochromaffin-like Cells in the Gastric Corpus

(2013) Hui Joyce Li et al.   GASTROENTEROLOGY

Purinergic Autocrine Regulation of Mechanosensitivity and Serotonin Release in a Human EC Model

(2013) Andrómeda Liñán-Rico et al.   INFLAMMATORY BOWEL DISEASES

Important role of mucosal serotonin in colonic propulsion and peristaltic reflexes:in vitroanalyses in mice lacking tryptophan hydroxylase 1

(2013) Dante J. Heredia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells

(2013) Ravinarayan Raghupathi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Ranolazine inhibits shear sensitivity of endogenous Na+current and spontaneous action potentials in HL-1 cells

(2012) Peter Strege et al.   Channels

Activation of Colonic Mucosal 5-HT4 Receptors Accelerates Propulsive Motility and Inhibits Visceral Hypersensitivity

(2012) Jill M. Hoffman et al.   GASTROENTEROLOGY

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?

(2011) Nick J. Spencer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion

(2011) A. Chin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

(2011) Chilman Bae et al.   BIOCHEMISTRY

Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation

(2011) H. J. Li et al.   DIABETES OBESITY & METABOLISM

Eukaryotic Mechanosensitive Channels

(2010) Jóhanna Árnadóttir et al.   Annual Review of Biophysics

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

(2010) Vijay K Yadav et al.   NATURE MEDICINE

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Evidence of fast serotonin transmission in frog slowly adapting type 1 responses

(2010) Daniel Press et al.   SOMATOSENSORY AND MOTOR RESEARCH

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells

(2009) Hitoshi Doihara et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy

(2008) Yuri A. Saito et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Localized Release of Serotonin (5-Hydroxytryptamine) by a Fecal Pellet Regulates Migrating Motor Complexes in Murine Colon

(2008) Dante J. Heredia et al.   GASTROENTEROLOGY

Interactions between integrin αIIbβ3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans

(2008) Ana Marin D. Carneiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Purinergic receptors and gastrointestinal secretomotor function

(2008) Fievos Leontiou Christofi   Purinergic Signalling