Article
Neurosciences
Hsuan-Yu Wan, Joshua C. Weavil, Taylor S. Thurston, Vincent P. Georgescu, Candice K. Morrissey, Markus Amann
Summary: There are differences in cardiovascular responses between men and women in response to muscle mechanorellex (MMR) and chemorellex (CR) activation. The interaction between these reflexes and its hemodynamic consequences vary between the sexes. The activation of MMR and CR by passive leg movement and exposure to hypoxia or hypercapnia showed additive effects in men and hyper-additive effects in women. The interaction of MMR and CR has significant influence on autonomic cardiovascular control, with responses differing between men and women.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Physiology
Andre L. Teixeira, Jordan B. B. Lee, Massimo Nardone, Jamie F. F. Burr, Philip J. J. Millar
Summary: The sympathetic nervous system plays a crucial role in cardiovascular regulation, particularly in response to acute stress. The relationship between renal and leg vasoconstriction at rest or during sympathetic stressors is not yet known. This study aimed to investigate the relationships between muscle sympathetic nerve activity (MSNA), leg vascular conductance (LVC), and renal vascular conductance (RVC) in young healthy adults, both at rest and during laboratory-based stressors. The findings revealed differential control of regional sympathetic vasoconstriction at rest and during stress in young healthy humans.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew W. D'Souza, Sarah L. Hissen, Kazumasa Manabe, Ryosuke Takeda, Takuro Washio, Geoff B. Coombs, Belinda Sanchez, Qi Fu, J. Kevin Shoemaker
Summary: Sympathetic vascular transduction is attenuated in older adults compared to young adults, and there is an inverse relationship between the central and peripheral arcs of the baroreflex. Age and sex have independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Neurosciences
Ana Luiza C. Sayegh, Jui-Lin Fan, Lauro C. Vianna, Mathew Dawes, Julian F. R. Paton, James P. Fisher
Summary: This study compared the cardiorespiratory and sympathetic neurocirculatory responses to chemoreflex activation between healthy men and women. The results showed that young women displayed augmented sympathetic responses and attenuated respiratory responses during central chemoreflex activation.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Multidisciplinary Sciences
Luis Monteiro Rodrigues, Clemente Gomes Rocha, Margarida Esteves Florindo, Joao Gregorio
Summary: The significance of lower limb perfusion asymmetries remains unknown in healthy individuals. Our study aims to understand how factors such as posture, sex, age, and body weight relate to perfusion. Data from studies previously published by our group show that body position is a primary determinant of perfusion asymmetry, especially in women, while the effects of sex and age were also analyzed. The study suggests that aging is a critical determinant in the upright study sample, with older males showing higher baseline asymmetries and longer recoveries after challenge.
Review
Clinical Neurology
Vaughan G. Macefield
Summary: This review discusses the development of microneurography and its contributions to understanding sensorimotor control and sympathetic outflow. It summarizes different approaches to recording nerve activity, considerations for recording quality, and analytical methods for maximizing information content.
CLINICAL AUTONOMIC RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Andre L. Teixeira, Ayesha Gangat, Philip J. Millar
Summary: A single high-fat Western meal impairs the ability of young healthy adults to counteract vascular responsiveness to sympathetic activation during exercise, highlighting the potential deleterious vascular effects associated with the consumption of a Western diet.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sameed Ahmed, Jennifer C. Sullivan, Anita T. Layton
Summary: A personalized model for hypertension treatment based on sex and pathophysiological features was developed, revealing the significant roles these factors play in the response to hypertensive treatments.
Article
Physiology
Yasmine Coovadia, Tessa E. Adler, Patrick W. Martin-Arrowsmith, Charlotte W. Usselman
Summary: Sex differences in neurovascular transduction during cold pressor test (CPT)-mediated sympathoexcitation were examined. Men experience robust CPT-induced MAP responses that are driven by both neurovascular (MSNA-FVR) and neurohemodynamic (MSNA-MAP) coupling, whereas these relationships were not observed in women.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Sociology
Shruti Chaudhry
Summary: This article explores how cross-sex friendships among older adults of South Asian heritage in Scotland reflect the norms of gender, sexualities, and intimate relationships in minority ethnic contexts. It argues that South Asian cultural norms pose challenges to the formation and maintenance of cross-sex friendships, which need to be managed in relation to familial ties and community expectations. The risks are particularly high for women, who face policing of their sexuality even as they age. These friendships signify social change and agency within diasporic communities, while also highlighting the ongoing importance of kin and community.
SOCIOLOGICAL RESEARCH ONLINE
(2022)
Review
Peripheral Vascular Disease
Thomas C. Hinton, Zoe H. Adams, Richard P. Baker, Katrina A. Hope, Julian F. R. Paton, Emma C. Hart, Angus K. Nightingale
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan C. L. Rodrigues, Galina Strelko, Esther A. H. Warnert, Amy E. Burchell, Sandra Neumann, Laura E. K. Ratcliffe, Ashley D. Harris, Benjamin Chant, Ruth Bowles, Angus K. Nightingale, Richard G. Wise, Julian F. R. Paton, Emma C. Hart
EUROPEAN RADIOLOGY
(2020)
Article
Endocrinology & Metabolism
Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Mueller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C. H. Fung, Richard B. Sessions, Fabien Alpy, Alice P. S. Kong, Peter Benke, Federico Torta, Adrian Kee Keong Teo, Isabelle Leclerc, Michele Solimena, Dale B. Wigley, Guy A. Rutter
MOLECULAR METABOLISM
(2020)
Article
Endocrinology & Metabolism
Joely A. Kellard, Nils J. G. Rorsman, Thomas G. Hill, Sarah L. Armour, Martijn van de Bunt, Patrik Rorsman, Jakob G. Knudsen, Linford J. B. Briant
MOLECULAR METABOLISM
(2020)
Article
Peripheral Vascular Disease
Matthew D. Kobetic, Amy E. Burchell, Laura E. K. Ratcliffe, Sandra Neumann, Zoe H. Adams, Regina Nolan, Angus K. Nightingale, Julian F. R. Paton, Emma C. Hart
Summary: The study found that untreated hypertensive men have lower sympathetic transduction compared to normotensive individuals, indicating that higher levels of MSNA are required to produce the same level of vasoconstrictor tone.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Nathan E. Manghat, Elizabeth Robinson, Konstantina Mitrousi, Jonathan C. L. Rodrigues, Thomas Hinton, Julian F. R. Paton, Richard G. Wise, Angus K. Nightingale, Emma C. Hart
Summary: Variants in the posterior anatomy of the cerebral circulation are associated with hypertension and poor cerebral perfusion in young adults, indicating potential long-term consequences on cerebrovascular health.
Article
Cardiac & Cardiovascular Systems
Iwan Harries, Giovanni Biglino, Kerrie Ford, Martin Nelson, Gui Rego, Prashant Srivastava, Matthew Williams, Bostjan Berlot, Estefania De Garate, Anna Baritussio, Kate Liang, Mai Baquedano, Nikesh Chavda, Christopher Lawton, Andrew Shearn, Sophie Otton, Lisa Lowry, Angus K. Nightingale, Juan Carlos Plana, David Marks, Costanza Emanueli, Chiara Bucciarelli-Ducci
Summary: This study aimed to analyze the cardiotoxicity of anthracycline using CMR, echocardiography, and MiRNAs, and identify factors affecting LVEF recovery. The results showed that CMR-derived MAPSE, circulating miRNA-181-5p, and miRNA-221-3p were associated with poor LVEF recovery 6 months after completion of chemotherapy.
IJC HEART & VASCULATURE
(2022)
Article
Cardiac & Cardiovascular Systems
Katrina Hope, Ben Chant, Thomas Hinton, Adrian H. Kendrick, Angus K. Nightingale, Julian F. R. Paton, Emma C. Hart
Summary: This study compared the V-E/VCO2 slope in patients with hypertension and normotensive individuals. It found that ventilatory efficiency is impaired in people with hypertension without heart failure. Future research is needed to determine if those hypertensive patients with elevated V-E/VCO2 slopes are at risk of developing heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Zoe H. Adams, Hazel C. Blythe, Nisha Charkoudian, Timothy B. Curry, Michael J. Joyner, Adrian H. Kendrick, Angus K. Nightingale, Ana P. Abdala Sheikh, Emma C. Hart
Summary: Respiratory modulation of sympathetic nerve activity is reduced in postmenopausal females, which is associated with higher resting blood pressure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)