Article
Cardiac & Cardiovascular Systems
Long Zhou, Xiaoxiao Wen, Yaguang Peng, Min Guo, Liancheng Zhao
Summary: The study found that both low and high levels of red blood cell folate were associated with an increased risk of severe abdominal aortic calcification in a representative sample of US adults.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Feng Xie, Yuan Xiao, Xiaozhong Li, Yanqing Wu
Summary: This study found that higher weight-adjusted-waist index (WWI) is associated with higher abdominal aortic calcification (AAC) score and increased risk of severe AAC in United States adults aged >= 40 years. This association was consistent across different population settings. Further studies are needed to confirm this relationship in other populations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nuozhou Liu, Ying Feng, Yuejuan Zhan, Fang Ma
Summary: This study aimed to evaluate the relationship between blood cadmium levels and abdominal aortic calcification (AAC). The results showed that there might be positive associations between blood cadmium levels and AAC scores and the risk of severe AAC. However, these associations were partially explained by smoking exposure. It is important to note that factors such as gender, smoking, and BMI may influence this relationship.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yubo Liu, Liao Tan, Yuanyuan Kuang, Yinzhuang Zhang, Ping Wang, Chenxi Liu, Qilin Ma
Summary: This study found that lower dietary copper intake is significantly associated with a higher prevalence of severe abdominal aortic calcification (AAC), while supplemental copper intake or serum copper levels are not significantly associated with AAC.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Nutrition & Dietetics
Xingwei Huo, Shanshan Jia, Xin Zhang, Lirong Sun, Xueting Liu, Lu Liu, Xianghao Zuo, Xiaoping Chen
Summary: A higher dietary intake of live microbes was associated with lower abdominal aortic calcification (AAC) scores and a lower risk of severe AAC. Further research is needed to confirm these findings.
FRONTIERS IN NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Liangliang Wang, Qiang Li, Baolin Su, En Zhang, Shu Zhang, Haitao Tu, Liangyou Zhang, Chao Wang, Gangyi Chen
Summary: This study examined the historical relationship between eGFR and abdominal aortic calcification (AAC) in the general population of the United States. The results showed a U-shaped association between eGFR and AAC score in adults, with an inflection point at approximately 76.43 ml/min/1.73 m2.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ying Zhou, Fu Zhi, Beibei Gao, Shengen Liao
Summary: This study found a significant association between the TyG index and the risk of abdominal aortic calcification (AAC). The TyG index, calculated through logarithmic transformation of triglycerides multiplied by glucose, can serve as a marker in clinical practice for assessing the risk of AAC.
BMC ENDOCRINE DISORDERS
(2022)
Article
Nutrition & Dietetics
YuJiao Sun, HuanRui Zhang, Wen Tian
Summary: This study found a negative association between dietary fiber intake and severe AAC in US adults, with a 28% reduction in the odds of severe AAC for every one standard deviation increase in dietary fiber intake.
Article
Nutrition & Dietetics
Surabhi Bhutani, Amanda C. McClain
Summary: Obesity and olfactory dysfunction are associated with poor diet, and obesity-related markers may shape this relationship.
Article
Cardiac & Cardiovascular Systems
Wei Li, Zhenwei Wang, Min Li, Jing Xie, Jing Gong, Naifeng Liu
Summary: This cross-sectional study aimed to prove the association between a body shape index (ABSI) and abdominal aortic calcification (AAC). The results showed that higher ABSI was closely associated with a higher proportion of AAC, and ABSI had a significantly higher discriminant ability for AAC compared to height, weight, BMI, waist circumference, and waist-to-height ratio. This study reveals the close relationship between ABSI and AAC.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Jingkai Wei, Mohammed K. Ali, Tiansheng Wang, Hanzhang Xu
Summary: The study showed that the presence of AAC and greater severity of AAC were associated with poorer cognitive function, particularly among participants under 75 years old. Further research is expected to explore whether reducing global vascular risk can help slow cognitive decline.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Kaisaierjiang Kadier, Anniwaer Abulizi, Aikeliyaer Ainiwaer, Rena Rehemuding, Xiang Ma, Yi-Tong Ma
Summary: This study aimed to explore the association between periodontitis and abdominal aortic calcification (AAC). The findings showed that periodontitis is associated with an increased risk of severe AAC in the US population aged 40 years and older.
Article
Biochemistry & Molecular Biology
Chang Liu, Dan Liang
Summary: The study investigated the relationship between dietary copper intake and abdominal aortic calcification (AAC) in US adults using data from NHANES 2013-2014. The results showed a negative association between copper intake and AAC scores and risk of AAC and severe AAC. Higher copper intake was associated with decreased AAC scores and decreased likelihood of AAC and severe AAC.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Xiaohua Wang, Shuo Yang, Gansheng He, Lin Xie
Summary: This study aimed to investigate the relationship between weight-adjusted waist index (WWI) and total bone mineral density (BMD) in US adolescents. The results showed a significant negative association between WWI and total BMD, with a non-linear relationship and saturation effect.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Frank Glover, Michael L. Eisenberg, Federico Belladelli, Francesco Del Giudice, Tony Chen, Evan Mulloy, W. Michael Caudle
Summary: This study examined the relationship between blood pressure and metabolites of organophosphate insecticides. The findings showed significant associations between different metabolites and systolic and diastolic blood pressure, as well as interactions with factors such as ethnicity, BMI, and age.
ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Ning Mao, Dingkun Zhang, Yupei Li, Ying Li, Jin Li, Li Zhao, Qingqin Wang, Zhu Cheng, Yin Zhang, Enshen Long
Summary: Environmental parameters have a significant impact on the spread of respiratory viral diseases. This study introduces the concept of dynamic virus deposition ratio and establishes a model to predict infection risk and highlight high-risk environmental conditions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Urology & Nephrology
Rong-zheng Yue, Ya-juan Li, Bai-hai Su, Cong-jun Li, Rui Zeng
Summary: This study found that atorvastatin can attenuate contrast-induced acute kidney injury by increasing the activity of renal tubular epithelial cells treated with the contrast agent, relieving cell injury, inhibiting pyroptosis and inflammation. Importantly, this mechanism is achieved by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway.
Article
Chemistry, Multidisciplinary
Qiao Yu, Baihai Su, Weifeng Zhao, Changsheng Zhao
Summary: A self-propelled chitosan-based hydrogel with CaCO3 was developed for efficient hemostasis, using the release of Ca2+ to accelerate clot formation and achieve excellent hemostatic efficiency.
Review
Immunology
Kaixi Chang, Yupei Li, Zheng Qin, Zhuyun Zhang, Liya Wang, Qinbo Yang, Jiwen Geng, Ningyue Deng, Shanshan Chen, Baihai Su
Summary: COVID-19 has caused unprecedented global impact and will continue to be prevalent due to its elusive pathophysiological mechanism and the continuous emergence of new variants. Critically ill patients with COVID-19 often experience cytokine storm, multiple organ dysfunction, and high mortality. Extracorporeal hemoadsorption has been shown to have an adjuvant effect in critically ill COVID-19 cases by regulating immune homeostasis, reducing viremia, and decreasing endotoxin activity. However, there are controversies regarding the selection of hemofilters, timing of therapy initiation and termination, anticoagulation management, identification of target subgroups, and ultimate survival benefit. The purpose of this narrative review is to comprehensively summarize the rationale and latest clinical evidence for the use of hemoadsorption in critically ill COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Kaixi Chang, Yupei Li, Zheng Qin, Zhuyun Zhang, Liya Wang, Qinbo Yang, Baihai Su
Summary: This study aimed to quantify the relationship between alpha-Klotho and urinary albumin-to-creatinine ratio (ACR). The results showed a negative correlation between alpha-Klotho and ACR and revealed a nonlinear relationship between them. The study suggests that alpha-Klotho has potential as a serum marker and prophylactic or therapeutic agent.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Yilin Wang, Shanshan Wang, Xueqin He, Yupei Li, Tao Xu, Lin Xu, Bo Yang, Xinnian Fan, Weifeng Zhao, Changsheng Zhao
Summary: This study connected solid anticoagulant microspheres and bilirubin adsorbents with a wearable artificial liver, successfully treating hyperbilirubinemia in dogs. The double-deck column allowed for safe and effective whole blood hemoperfusion, but improvements are still needed in device intelligence and adsorbent versatility.
BIOACTIVE MATERIALS
(2023)
Article
Transplantation
Yi He, Ying Jin, Hen Xue, Runhan Liu, Mengyu Zhang, Ruoxi Liao, Maoli Chen, Xueli Zhou, Xueqin He, Min Qin, Kuo Li, Huiqun Zou, Ying Gan, Zhenlei Wang, Li Zheng, Hui Zhong, Ping Fu
Summary: This study investigated the pharmacokinetics and pharmacodynamics of sacubitril/valsartan (SV) in peritoneal dialysis (PD) patients with complications of hypertension or heart failure (HF). The results showed that the 100 mg twice daily group had the highest plasma maximum concentrations of valsartan, sacubitril, and LBQ657. After SV treatment, there was a decrease in mean sitting systolic and diastolic blood pressure, reduction in NT-proBNP levels, and increase in left ventricular ejection fraction. Overall, a dose of 100 mg BID SV was found to be safe and effective in PD patients with hypertension or HF complications.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Qianqian Pang, Yuping Xu, Ruoxi Liao, Ye Li, Li Zhang, Yue Chi, Xuan Qi, Mei Li, Yan Jiang, Ou Wang, Xiaoping Xing, Ling Qin, Weibo Xia
Summary: This study found that there are differences in bone microstructure between PHOAR1 and PHOAR2 patients, and that PHOAR1 patients have inferior bone microstructure and strength compared to PHOAR2 patients. Additionally, this study is the first to find differences in bone microstructure between PHOAR1 and PHOAR2 patients.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Materials Science, Multidisciplinary
Haifeng Ji, Yupei Li, Baihai Su, Weifeng Zhao, Jayachandran N. Kizhakkedathu, Changsheng Zhao
Summary: Hemodialysis is a common treatment for end-stage kidney disease, but the long-term contact of hemoincompatible hollow-fiber membranes (HFMs) can cause chronic inflammation, oxidative stress, and thrombosis, leading to increased cardiovascular diseases and mortality. This review analyzes the current progress in improving the hemocompatibility of HFMs and describes the design and clinical use of different HFMs. The adverse interactions between blood and HFMs, including protein adsorption, platelet adhesion and activation, and the activation of immune and coagulation systems, are discussed, along with strategies to improve the hemocompatibility of HFMs.
ADVANCED FIBER MATERIALS
(2023)
Review
Hematology
Yupei Li, Xinyao Luo, Mei Yang, Baihai Su
Summary: Oxidative stress is common in patients receiving chronic hemodialysis and is associated with cardiovascular disease burden and increased mortality risks. The use of vitamin E-coated membranes to reduce oxidative stress during hemodialysis is controversial. Novel antioxidant hemodialysis membranes have been developed to replace vitamin E-coated membranes, but research progress in this area has been limited.
BLOOD PURIFICATION
(2023)
Article
Engineering, Multidisciplinary
Ziyue Ling, Chunji Jiang, Xianda Liu, Yupei Li, Weifeng Zhao, Changsheng Zhao
Summary: Researchers have developed a new type of hemoperfusion adsorbent, polyacrylonitrile/polyimidazolium bromide composite microspheres, which exhibit excellent antibacterial properties and endotoxin removal capability, making them suitable for the treatment of sepsis patients.
COMPOSITES PART B-ENGINEERING
(2023)
Review
Critical Care Medicine
Yupei Li, Yu Chen, Tinghang Yang, Kaixi Chang, Ningyue Deng, Weifeng Zhao, Baihai Su
Summary: Both HMGB1 and histones play major roles in mediating inflammation, immune thrombosis, and organ dysfunction in critical illnesses. Targeting them with specific antibodies or inhibitors has shown promise in animal models, but their routine clinical use is not recommended. On the other hand, extracorporeal blood purification may remove these DAMPs and exert an immunomodulatory effect in critically ill patients. This review summarizes the immunopathological roles of HMGB1 and histones, discusses the rationale for using hemofilters to remove these DAMPs, and gathers the latest evidence for the use of extracorporeal blood purification to improve clinical outcomes in critically ill patients.
Article
Cardiac & Cardiovascular Systems
Yuqin Xiong, Yang Yu, Ke Huang, Ruoxi Liao, Liya Wang, Zhuyun Zhang, Jiameng Li, Zheng Qin, Si Sun, Yupei Li, Baihai Su
Summary: This study aimed to explore the impact of vascular calcification (VC) on blood pressure variability (BPV) in animal models of chronic kidney disease (CKD). The experiment revealed that VC accelerated the progression of CKD and caused abnormal BPV. This suggests that the effect of VC on BPV is independent of CKD.
CARDIORENAL MEDICINE
(2023)
