期刊
CELL CALCIUM
卷 57, 期 3, 页码 166-173出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2014.11.007
关键词
Animals; Calcium channels; Calcium signaling; Choanoflagellates; Evolution; Genomics
类别
资金
- Biotechnology and Biological Sciences Research Council
- Biotechnology and Biological Sciences Research Council [BB/K000942/1, BB/G013721/1] Funding Source: researchfish
- BBSRC [BB/G013721/1, BB/K000942/1] Funding Source: UKRI
The basic principles of Ca2+ regulation emerged early in prokaryotes. Ca2+ signaling acquired more extensive and varied functions when life evolved into multicellular eukaryotes with intracellular organelles. Animals, fungi and plants display differences in the mechanisms that control cytosolic Ca2+ concentrations. The aim of this review is to examine recent findings from comparative genomics of Ca2+ signaling molecules in close unicellular relatives of animals and in common unicellular ancestors of animals and fungi. Also discussed are the evolution and origins of the sperm-specific CatSper channel complex, cation/Ca2+ exchangers and four-domain voltage-gated Ca2+ channels. Newly identified evolutionary evidence suggests that the distinct Ca2+ signaling machineries in animals, plants and fungi likely originated from an ancient Ca2+ signaling machinery prior to early eukaryotic radiation. (C) 2014 Elsevier Ltd. All rights reserved.
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