Article
Nutrition & Dietetics
Anna Strueven, Stefan Brunner, Georges Weis, Christopher Stremmel, Daniel Teupser, Jenny Schlichtiger, Korbinian Lackermair
Summary: This study aimed to investigate the effect of isolated dehydration on cardiopulmonary exercise capacity. The results showed that dehydration caused a reduction in body water and an increase in urine osmolality, and led to decreased oxygen uptake, minute ventilation, and power output. The conclusion is that isolated dehydration impairs workload and peak oxygen uptake in recreational athletes, suggesting an important role of dehydration in the heat-induced reduction of exercise capacity.
Article
Respiratory System
Apama Balasubramanian, Nirupama Putcha, Neil R. MacIntyre, Robert L. Jensen, Gregory Kinney, William W. Stlinger, Craig P. Hersh, Russell P. Bowler, Richard Casaburi, MeiLan K. Han, Janos Porszasz, R. Graham Barr, Elizabeth Regan, Barry J. Make, Nadia N. Hansel, Robert A. Wise, Meredith C. McCormack
Summary: DLCO is a potential predictor of mortality in COPD patients, independent of BODE index and CT evidence. For every 10% decrease in DLCO percent predicted, mortality increases by 28%. Adding DLCO to BODE improves the predictive accuracy of the model for COPD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Devin B. Phillips, Matthew D. James, Amany F. Elbehairy, Kathryn M. Milne, Sandra G. Vincent, Nicolle J. Domnik, Juan P. De-Torres, J. Alberto Neder, Denis E. O'Donnell
Summary: The study suggests that in COPD patients, a combination of low resting DLCO and high exercise ventilatory requirements may be associated with early dynamic mechanical constraints, dyspnea, and exercise limitation.
Article
Pharmacology & Pharmacy
Elisabetta Zampogna, Nicolino Ambrosino, Federico Mattia Oliva, Monica Rudi, Giovanni Sotgiu, Laura Saderi, Antonio Spanevello, Dina Visca
Summary: This study evaluated the impact of pulmonary rehabilitation on heart rate recovery (HRR) in individuals with asthma compared to those with COPD. The findings showed that individuals with asthma had a lower prevalence of slow HRR than those with COPD. However, exercise training significantly improved exercise capacity in both populations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eva Csondor, Gellert Karvaly, Roland Ligetvari, Krisztian Kovacs, Zsolt Komka, Akos Mora, Timea Stromajer-Racz, Andras Olah, Miklos Toth, Pongrac acs
Summary: Athletes undergoing extreme physical stress show increased production of steroid hormones in the adrenal and gonadal glands. This stress-induced increase in steroid concentrations varies at different stages of stress, with the mineralocorticoid, glucocorticoid, and androgen pathways being activated simultaneously.
Article
Medicine, General & Internal
Michele Vitacca, Mara Paneroni, Beatrice Salvi, Antonio Spanevello, Piero Ceriana, Claudio Bruschi, Bruno Balbi, Maria Aliani, Nicolino Ambrosino
Summary: This study suggests that the success rate of pulmonary rehabilitation (PR) is not affected by airflow severity and outcome measures in individuals with severe COPD recovering from exacerbation. In addition to the commonly used outcome measures, Barthel dyspnoea index and Short Physical Performance Battery are also sensitive to PR.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xin Li, Yi Zhang, Qin Luo, Qing Zhao, Qixian Zeng, Tao Yang, Qi Jin, Lu Yan, Anqi Duan, Jiaran Liu, Chenhong An, Xiuping Ma, Changming Xiong, Zhihui Zhao, Zhihong Liu
Summary: A baseline DLCO < 70% and Delta DLCO > 6% can independently predict unfavorable responses to BPA. Dynamic measurement of DLCO facilitates the identification of patients who might have unsatisfactory hemodynamic results after BPA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Respiratory System
Yingmeng Ni, Youchao Yu, Ranran Dai, Guochao Shi
Summary: DLCO % predicted is significantly lower in COPD patients with more severe airflow limitation, more symptoms, and higher exacerbation risk. It is also associated with exacerbation patients, non-survivors, emphysema dominant phenotype, and pulmonary hypertension in COPD patients. The current meta-analysis suggests that DLCO % predicted may be an important measurement for evaluating COPD patients in terms of severity, exacerbation risk, mortality, emphysema domination, and presence of pulmonary hypertension.
CHRONIC RESPIRATORY DISEASE
(2021)
Article
Medicine, General & Internal
Klara Komici, Antonio Bianco, Fabio Perrotta, Antonio Dello Iacono, Leonardo Bencivenga, Vito D'Agnano, Aldo Rocca, Andrea Bianco, Giuseppe Rengo, Germano Guerra
Summary: Among competitive athletes with COVID-19, the most common symptoms were anosmia and ageusia. While there was a decrease in lung function during early recovery, exercise capacity and cardio-respiratory function were not significantly impaired.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Hamid Reza Nejabati, Mahsa Ghaffari-Novin, Nazila Fathi-Maroufi, Yousef Faridvand, Hans-Christer Holmberg, Ola Hansson, Saba Nikanfar, Mohammad Nouri
Summary: Exercise is considered a medicine for metabolic disorders, and dietary supplementation, such as MNAM, can enhance exercise performance. MNAM plays a crucial role in providing energy during exercise and fasting.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Medicine, General & Internal
Daniel Sliz, Szczepan Wiecha, Jakub S. Gasior, Przemyslaw Seweryn Kasiak, Katarzyna Ulaszewska, Marcin Lewandowski, Marcin Barylski, Artur Mamcarz
Summary: COVID-19 has a deteriorating impact on health, particularly for endurance athletes who rely on consistent training. This study examines the effects of mild COVID-19 on sleep, psychology, and cardiopulmonary exercise test results. The findings indicate a decline in exercise performance, which is influenced by sleep quality and psychological factors. It is important for medical professionals to encourage proper mental health and sleep among athletes recovering from COVID-19 infection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Elisabetta Zampogna, Mara Paneroni, Stefano Belli, Maria Aliani, Alessandra Gandolfo, Dina Visca, Maria Teresa Bellanti, Nicolino Ambrosino, Michele Vitacca
Summary: This study evaluated the effectiveness of pulmonary rehabilitation in hospitalized patients recovering from COVID-19, showing significant improvements in muscle weakness and physical performance impairment. The findings may guide clinicians in caring for patients surviving COVID-19 infection.
Article
Cardiac & Cardiovascular Systems
Caitlin C. Fermoyle, Glenn M. Stewart, Barry A. Borlaug, Bruce D. Johnson
Summary: Patients with heart failure with preserved ejection fraction (HFpEF) exhibit lower lung diffusing capacity at rest and during exercise due to impaired gas conductance across the alveolar-capillary membrane. DLCO is impaired for a given pulmonary capillary wedge pressure and pulmonary arterial compliance. These findings provide new insights into the complex relationships between hemodynamic perturbations and gas exchange abnormalities in HFpEF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Respiratory System
Teresa Sassmann, Philipp Douschan, Vasile Foris, Natascha Troester, Katarina Zeder, Luka Brcic, Adrienn Tornyos, Gerhard Bachmaier, Michael Fuchsjaeger, Horst Olschewski, Gabor Kovacs
Summary: Even in the absence of significant pulmonary hypertension at rest, COPD patients show characteristic abnormalities in pulmonary hemodynamics during exercise, which may impact exercise capacity.
RESPIRATORY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Erika Zavaglia Kabbach, Alessandro Domingues Heubel, Cassia da Luz Goulart, Valeria Amorim Pires Di Lorenzo, Shane A. Phillips, Audrey Borghi-Silva, Renata Goncalves Mendes
Summary: The study found a positive correlation between exercise capacity and endothelial function in patients with severe AECOPD, with endothelial function increasing with longer walked distances. Further research is needed to explore the effectiveness of rehabilitation on exercise capacity and endothelial function in these patients, as well as its prognostic value.
SCIENTIFIC REPORTS
(2021)