Article
Cardiac & Cardiovascular Systems
Raquel Lopez-Vilella, Silvia Lozano-Edo, Patricia Arenas Martin, Pablo Jover-Pastor, Meryem Ezzitouny, Jose Sorolla Romero, Maria Calvo Asensio, Julia Martinez-Sole, Borja Guerrero Cervera, Jose Carlos Sanchez Martinez, Victor Donoso Trenado, Ignacio Sanchez-Lazaro, Luis Martinez Dolz, Luis Almenar Bonet
Summary: Intravenous iron administration improved ejection fraction and cardiac functional status in outpatients with iron deficiency and heart failure, regardless of preserved or reduced ejection fraction type.
Review
Nutrition & Dietetics
Hana Manceau, Jerome Ausseil, Damien Masson, Jean-Paul Feugeas, Bernard Sablonniere, Regis Guieu, Herve Puy, Katell Peoc'h
Summary: Iron deficiency is a significant comorbidity of heart failure, often leading to rehospitalizations and reduced survival rates, however, correction with iron supplementation can improve functional capacity and quality of life in patients.
Article
Cardiac & Cardiovascular Systems
Stefan D. Anker, Piotr Ponikowski, Muhammad Shahzeb Khan, Tim Friede, Ewa A. Jankowska, Vincent Fabien, Udo-Michael Goehring, Marco Metra, Ileana L. Pina, Andrew J. S. Coats, Giuseppe Rosano, Fabio Dorigotti, Josep Comin-Colet, Dirk J. Van Veldhuisen, Gerasimos S. Filippatos, Javed Butler
Summary: This study analyzed data of iron-deficient patients with chronic heart failure receiving ferric carboxymaltose (FCM), showing that FCM had a significantly higher likelihood of improvement and a reduced likelihood of deterioration in the 6-minute walk test (6MWT) compared to placebo.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Mohamad F. Barakat, George Amin-Youseff, Darlington O. Okonko
Summary: This study focuses on the improvement of exercise capacity and quality of life in heart failure patients through oral sucrosomial iron, as a nonrandomized, open-label, proof-of-concept study.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Multidisciplinary Sciences
Hironobu Fujisawa, Masaru Nakayama, Naoki Haruyama, Akiko Fukui, Ryota Yoshitomi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
Summary: This study found that lower and higher transferrin saturation (TSAT) and serum ferritin levels were independent risk factors for kidney disease progression in patients with chronic kidney disease (CKD).
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Constantinos Bakogiannis, Dimitrios Mouselimis, Anastasios Tsarouchas, Christodoulos E. E. Papadopoulos, Efstratios K. K. Theofillogiannakos, Elmira Lechat, Antonios P. P. Antoniadis, Efstathios D. D. Pagourelias, Ioannis Kelemanis, Stergios Tzikas, Nikolaos Fragakis, Georgios K. K. Efthimiadis, Theodoros D. D. Karamitsos, Michael Doumas, Vassilios P. Vassilikos
Summary: The RESAFE-HF registry study aims to investigate the impact of intravenous ferric carboxymaltose on the arrhythmic burden of patients with heart failure. The primary endpoint includes iron-related parameters such as hemoglobin, ferritin, and transferrin saturation, while secondary endpoints cover various markers and quality of life measures.
Article
Clinical Neurology
Lourdes M. DelRosso, Lilith M. Reuter-Yuill, Yeilim Cho, Raffaele Ferri, Maria P. Mogavero, Daniel L. Picchietti
Summary: Restless legs syndrome (RLS) may be underdiagnosed in children with autism spectrum disorder (ASD), and intravenous ferric carboxymaltose (FCM) appears to be a promising treatment for this subset of children, resulting in clinical improvement and better iron parameters.
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Paul Welsh, Subodh Verma, Rudolf A. De Boer, Eileen O'Meara, Olof Bengtsson, Lars Kober, Mikhail N. Kosiborod, Ann Hammarstedt, Anna Maria Langkilde, Daniel Lindholm, Dustin J. Little, Mikaela Sjostrand, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, David A. Morrow, Morten Schou, Scott D. Solomon, Naveed Sattar, Pardeep S. Jhund, John J. McMurray
Summary: This study examined the prevalence and consequences of iron deficiency in heart failure patients and found that it was associated with worse outcomes. Dapagliflozin had an effect on markers of iron metabolism and improved outcomes regardless of iron status at baseline.
Article
Clinical Neurology
Lourdes M. DelRosso, Raffaele Ferri, Maida L. Chen, Vidhi Kapoor, Richard P. Allen, Maria Paola Mogavero, Daniel L. Picchietti
Summary: The study evaluated the effectiveness and tolerability of intravenous ferric carboxymaltose (IV FCM) in children with restless legs syndrome (RLS) or periodic limb movement disorder (PLMD), showing improvements in clinical symptoms and iron indices with well-tolerated treatment. Adverse events were minimal.
Article
Clinical Neurology
Lourdes M. DelRosso, Daniel L. Picchietti, Raffaele Ferri
Summary: This study evaluated the response to iron supplementation in pediatric sleep disorder restless sleep disorder (RSD) and found that intravenous iron treatment was more effective than oral iron. Patients showed significant improvement in clinical and laboratory parameters after intravenous iron treatment.
Article
Cardiac & Cardiovascular Systems
Mohammad Hamza, Yasar Sattar, Nouraldeen Manasrah, Neel Navinkumar Patel, Amna Rashdi, Resha Khanal, Hamza Naveed, Maha Zafar, Ahsan Mahmood Khan, Anas Alharbi, Muhammad Aamir, Karthik Gonuguntla, Sameer Raina, Sudarshan Balla
Summary: Iron deficiency is an independent risk factor for exacerbation of heart failure. This study aimed to evaluate the safety and efficacy of intravenous iron therapy in patients with heart failure with reduced ejection fraction (HFrEF). A literature search identified 12 studies with a total of 4,376 patients. The results showed that intravenous iron therapy was safe and significantly reduced HF readmissions compared to standard of care.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Pietro Ameri, Edoardo Bertero, Christoph Maack, John R. Teerlink, Giuseppe Rosano, Marco Metra
Summary: Recent trials have shown the effectiveness of new drugs in treating heart failure with reduced ejection fraction (HFrEF), such as SGLT2 inhibitors and iron repletion with ferric carboxymaltose. These new treatments have shown to reduce hospitalizations and improve quality of life for patients with HFrEF. Additionally, new-generation potassium binders may help initiate and titrate renin-angiotensin-aldosterone system inhibitors. Vericiguat and omecamtiv mecarbil have also shown potential for tailored approaches to improving hemodynamic status in HFrEF patients. Overall, these results indicate a new era for more personalized medical treatment for HFrEF.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Jasper Tromp, Brian L. Claggett, Jiankang Liu, Alice M. Jackson, Pardeep S. Jhund, Lars Kober, Jiri Widimsky, Sergey A. Boytsov, Vijay K. Chopra, Inder S. Anand, Junbo Ge, Chen-Huan Chen, Aldo P. Maggioni, Felipe Martinez, Milton Packer, Marc A. Pfeffer, Burkert Pieske, Margaret M. Redfield, Jean L. Rouleau, Dirk J. Van Veldhuisen, Faiez Zannad, Michael R. Zile, Adel R. Rizkala, Akiko Inubushi-Molessa, Martin P. Lefkowitz, Victor C. Shi, John J. McMurray, Scott D. Solomon, Carolyn S. P. Lam
Summary: In the PARAGON-HF trial, regional differences in clinical characteristics and outcomes were observed among patients with HFpEF, which may have implications for the design of future clinical trials.
CIRCULATION-HEART FAILURE
(2021)
Article
Medicine, General & Internal
Antonio Lacquaniti, Romana Gargano, Susanna Campo, Teresa Casuscelli di Tocco, Silvia Schifilliti, Paolo Monardo
Summary: This study analyzed the effects of switching from ferric gluconate (FG) to ferric carboxymaltose (FCM) therapy on iron metabolism, anemia, and economic implications in chronic hemodialysis patients. The results showed that FCM treatment reduced ESA dose requirements, improved iron status, and was more cost-effective compared to FG treatment.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Yogesh N. V. Reddy, Katlyn E. Koepp, Rickey Carter, Sithu Win, Christopher Charles Jain, Thomas P. Olson, Bruce D. Johnson, Robert Rea, Margaret M. Redfield, Barry A. Borlaug
Summary: In patients with HFpEF and chronotropic incompetence, implanting and programming a pacemaker for rate-adaptive atrial pacing did not improve exercise performance and was associated with increased adverse events.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Plant Sciences
Vincenzo Musolino, Roberta Macri, Antonio Cardamone, Maria Serra, Anna Rita Coppoletta, Luigi Tucci, Jessica Maiuolo, Carmine Lupia, Federica Scarano, Cristina Carresi, Saverio Nucera, Irene Bava, Mariangela Marrelli, Ernesto Palma, Micaela Gliozzi, Vincenzo Mollace
Summary: This study used a polystyrene resin to recover polyphenolic compounds from the leaf extract of Nocellara del Belice cultivar and evaluated their antioxidant and anti-inflammatory activities. The extract showed good radical scavenging capability and was able to reduce intracellular lipid accumulation.
Review
Chemistry, Medicinal
Aikaterini Andreadi, Saverio Muscoli, Rojin Tajmir, Marco Meloni, Alessandro Minasi, Carolina Muscoli, Sara Ilari, Vincenzo Mollace, David Della Morte, Alfonso Bellia, Elena Campione, Nicola Di Daniele, Davide Lauro
Summary: The link between acne and insulin resistance in males has not been studied as extensively as in females, despite the increasing prevalence of acne in adult men. Metformin, a medication that increases insulin sensitivity, may affect the relationship between acne vulgaris and insulin resistance. However, further clinical studies are needed to confirm these assumptions.
Review
Biology
Jessica Maiuolo, Rosa Maria Bulotta, Francesca Oppedisano, Francesca Bosco, Federica Scarano, Saverio Nucera, Lorenza Guarnieri, Stefano Ruga, Roberta Macri, Rosamaria Caminiti, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Antonio Cardamone, Annarita Coppoletta, Martina Nicita, Adriano Carnevali, Vincenzo Scorcia, Vincenzo Mollace
Summary: Eye health is crucial and diseases can greatly impact vision and quality of life. Natural antioxidants and nutraceutical supplementation can counteract oxidative stress in early stages of eye diseases and improve vision. Combining nutraceuticals and antioxidants may be a promising solution for eye protection.
Review
Agronomy
Jessica Maiuolo, Rocco Mollace, Francesca Bosco, Federica Scarano, Francesca Oppedisano, Saverio Nucera, Stefano Ruga, Lorenza Guarnieri, Roberta Macri, Irene Bava, Cristina Carresi, Micaela Gliozzi, Vincenzo Musolino, Antonio Cardamone, Anna Rita Coppoletta, Andrea Barillaro, Virginia Simari, Daniela Salvemini, Ernesto Palma, Vincenzo Mollace
Summary: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of liver-related health issues. There is currently no unique drug treatment for NAFLD, and natural products such as bergamot polyphenolic fraction (BPF) and Cynara cardunculus extract have shown potential in counteracting the disease's effects. These extracts have been shown to inhibit lipid accumulation, oxidative stress, inflammation, and fibrosis in liver cells, leading to improved cardiac and endothelial function. Supplementation with BPF and Cynara cardunculus extract may offer a novel approach in preventing and treating NAFLD-related complications.
Article
Biochemistry & Molecular Biology
Francesca Bosco, Lorenza Guarnieri, Saverio Nucera, Miriam Scicchitano, Stefano Ruga, Antonio Cardamone, Samantha Maurotti, Cristina Russo, Anna Rita Coppoletta, Roberta Macri, Irene Bava, Federica Scarano, Fabio Castagna, Maria Serra, Rosamaria Caminiti, Jessica Maiuolo, Francesca Oppedisano, Sara Ilari, Filomena Lauro, Luigi Giancotti, Carolina Muscoli, Cristina Carresi, Ernesto Palma, Micaela Gliozzi, Vincenzo Musolino, Vincenzo Mollace
Summary: The aim of this study was to evaluate if chronic constriction injury (CCI) of the sciatic nerve in rats can be a valid model to study muscle atrophy and consequent osteoporosis. The results showed that CCI can cause significant decreases in muscle mass and bone mass and alterations in the expression of molecular markers of muscle atrophy and osteoporosis. This study suggests that CCI may serve as a valid approach to study muscle-bone crosstalk and to identify new strategies to prevent osteosarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Francesca Bosco, Stefano Ruga, Rita Citraro, Antonio Leo, Lorenza Guarnieri, Jessica Maiuolo, Francesca Oppedisano, Roberta Macri, Federica Scarano, Saverio Nucera, Irene Bava, Ernesto Palma, Carolina Muscoli, Juan Hancke, Giovambattista De Sarro, Vincenzo Mollace
Summary: Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are common worldwide. Aging process is the most significant risk factor, but genetic and environmental factors also play a role. Lifestyle and natural products containing antioxidant and anti-inflammatory properties can have preventive and therapeutic effects. Andrographis paniculata and its main constituent, andrographolide, have shown neuroprotective effects by modulating neurodegeneration and neuroinflammation.
Article
Plant Sciences
Vincenzo Musolino, Roberta Macri, Antonio Cardamone, Luigi Tucci, Maria Serra, Carmine Lupia, Samantha Maurotti, Rosario Mare, Saverio Nucera, Lorenza Guarnieri, Mariangela Marrelli, Anna Rita Coppoletta, Cristina Carresi, Micaela Gliozzi, Vincenzo Mollace
Summary: This study extracted terpenoids-rich and polyphenols-rich rosemary extracts through maceration and ultrasound sonication, and investigated their phytochemical characteristics, antioxidant activity, and potential benefits in reducing lipid accumulation in NAFLD.
Article
Health Care Sciences & Services
Marco Alfonso Perrone, Ferdinando Iellamo, Valentino D'Antoni, Alessandro Gismondi, Deborah Di Biasio, Sara Vadala, Giuseppe Marazzi, Valentina Morsella, Maurizio Volterrani, Giuseppe Caminiti
Summary: This study aimed to assess acute changes in left atrial (LA) function during incremental aerobic exercise in heart failure patients and compare them with healthy subjects. The results showed that patients with mildly reduced ejection fraction showed a proper increase in LA reservoir function, which helped maintain stroke volume during exercise.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Giuseppe Caminiti, Marco Alfonso Perrone, Valentino DAntoni, Giuseppe Marazzi, Alessandro Gismondi, Sara Vadala, Deborah Di Biasio, Vincenzo Manzi, Ferdinando Iellamo, Maurizio Volterrani
Summary: Left atrial dysfunction is associated with exercise intolerance and poor prognosis in heart failure (HF). The effects of exercise training on atrial function in patients with HF with mid-range ejection fraction (HFmrEF) are unknown. This study aimed to assess the effects of a supervised concurrent training (SCT) program on left atrial function in HFmrEF patients. Results showed that SCT improved left atrial and left ventricular function in HFmrEF, with significant increases in exercise duration, distance walked, and measures of atrial strain compared to the control group.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Roberta Macri, Irene Bava, Federica Scarano, Rocco Mollace, Vincenzo Musolino, Micaela Gliozzi, Marta Greco, Daniela Foti, Luigi Tucci, Jessica Maiuolo, Cristina Carresi, Annamaria Tavernese, Ernesto Palma, Carolina Muscoli, Vincenzo Mollace
Summary: This study aimed to test the effects of Ferutinin rich-Ferula communis L. root extract (FcFE) at different concentrations on H9C2 cells and evaluate its antioxidant properties in cardiomyocytes to explore new potential therapeutic activities. The results showed that FcFE could protect against Doxorubicin-induced cardiotoxicity. Further molecular characterization of this natural compound may open the way for testing FcFE at low concentrations in vivo and in clinical studies as an adjuvant in cancer therapy to prevent side effects on heart cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rocco Mollace, Roberta Macri, Martina Nicita, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Irene Bava, Jessica Maiuolo, Annamaria Tavernese, Antonio Cardamone, Luigi Tucci, Giuseppe Trunfio, Elzbieta Janda, Ernesto Palma, Carolina Muscoli, Francesco Barilla, Massimo Federici, Federica Scarano, Vincenzo Mollace
Summary: Evidence suggests that the gut microbiota plays a role in the alterations of lipid metabolism associated with high-fat diet. Recent evidence indicates that supplementation with natural polyphenols and fibres can improve high-fat diet-induced dysbiosis and improve the lipidaemic profile. This study aimed to investigate the protective effect of bergamot polyphenolic extract and fibres on high-fat diet-induced dyslipidaemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Rosita Stanzione, Maurizio Forte, Maria Cotugno, Francesca Oppedisano, Cristina Carresi, Simona Marchitti, Vincenzo Mollace, Massimo Volpe, Speranza Rubattu
Summary: High salt load is damaging to vascular cells and a risk factor for cardiovascular diseases. In this study, we tested the effects of a bergamot polyphenolic fraction (BPF) on high-salt-induced injury in cerebral endothelial cells. BPF reduced oxidative stress, improved cell viability and angiogenesis, and decreased mitochondrial oxidative stress. BPF may be a valuable adjunct for treating vascular disorders.