Integration of transcriptomics and metabonomics revealed the protective effects of hemp seed oil against methionine–choline-deficient diet-induced non-alcoholic steatohepatitis in mice

A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR)

(2022) Shipeng Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

Biological Mechanisms and Related Natural Inhibitors of CD36 in Nonalcoholic Fatty Liver

(2022) Yanan Feng et al.   Drug Design Development and Therapy

Therapeutic potential of puerarin against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis determined by combination of 1H NMR spectroscopy-based metabonomics and 16S rRNA gene sequencing

(2021) Meng-juan Gong et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The Effect of Hemp (Cannabis sativa L.) Seeds and Hemp Seed Oil on Vascular Dysfunction in Obese Male Zucker Rats

(2021) Michał Majewski et al.   Nutrients

Antioxidant Activity of Hemp (Cannabis sativa L.) Seed Oil in Drosophila melanogaster Larvae under Non-Stress and H2O2-Induced Oxidative Stress Conditions

(2021) Jelena Vitorović et al.   Antioxidants

Exploring the potential mechanism of Rhodomyrtus tomentosa (Ait.) Hassk fruit phenolic rich extract on ameliorating nonalcoholic fatty liver disease by integration of transcriptomics and metabolomics profiling

(2021) Ruimin Wang et al.   FOOD RESEARCH INTERNATIONAL

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

(2020) Jorge Simon et al.   Cell Metabolism

One-Carbon Metabolism in Fatty Liver Disease and Fibrosis: One-Carbon to Rule Them All

(2020) Robin P da Silva et al.   JOURNAL OF NUTRITION

The Seed of Industrial Hemp (Cannabis sativa L.): Nutritional Quality and Potential Functionality for Human Health and Nutrition

(2020) Barbara Farinon et al.   Nutrients

Hepatic PEMT activity mediates liver health, weight gain, and insulin resistance

(2019) Sereana Wan et al.   FASEB JOURNAL

Plasma metabolic alterations in patients with severe obesity and non-alcoholic steatohepatitis

(2019) Noemí Cabré et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells

(2018) Kuo Du et al.   GASTROENTEROLOGY

Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease

(2018) Donald B. Jump et al.   PHARMACOLOGY & THERAPEUTICS

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism

(2017) Jiang Li et al.   PLoS One

Betaine chemistry, roles, and potential use in liver disease

(2016) Christopher R. Day et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors

(2016) Nadine Gehrke et al.   JOURNAL OF HEPATOLOGY

Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency

(2016) Silvia Sookoian et al.   LIVER INTERNATIONAL

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

Cross-talk between branched-chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease

(2015) Nishanth E. Sunny et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

(2014) April D. Lake et al.   AMINO ACIDS

Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation

(2013) Thuc T. Le et al.   JOURNAL OF LIPID RESEARCH

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Relationship Between Plasma Uridine and Insulin Resistance in Patients with Non-Insulin-Dependent Diabetes Mellitus

(2010) Tetsuya Yamamoto et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Systems Biological Responses to Chronic Perfluorododecanoic Acid Exposure by Integrated Metabonomic and Transcriptomic Studies

(2009) Lina Ding et al.   JOURNAL OF PROTEOME RESEARCH

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL