Glycoside Hydrolase Catalysis: Do Substrates and Mechanism-Based Covalent Inhibitors React via Matching Transition States?

Time Evolution of the Millisecond Allosteric Activation of Imidazole Glycerol Phosphate Synthase

(2022) Carla Calvó-Tusell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fundamental Insight into Glycoside Hydrolase-Catalyzed Hydrolysis of the Universal Koshland Substrates–Glycopyranosyl Fluorides

(2021) Marco Farren-Dai et al.   ACS Catalysis

Conformationally Controlled Reactivity of Carbasugars Uncovers the Choreography of Glycoside Hydrolase Catalysis

(2020) Pal John Pal Adabala et al.   JOURNAL OF ORGANIC CHEMISTRY

Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases

(2020) Nicholas G. S. McGregor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An overview of activity-based probes for glycosidases

(2019) Liang Wu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

(2018) Weiwu Ren et al.   Nature Communications

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

(2017) Daniël Lahav et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CH/π Interactions in Carbohydrate Recognition

(2017) Vojtěch Spiwok   MOLECULES

Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars

(2016) Christopher Adamson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Allostery and Conformational Dynamics

(2016) Jingjing Guo et al.   CHEMICAL REVIEWS

Protein Ensembles: How Does Nature Harness Thermodynamic Fluctuations for Life? The Diverse Functional Roles of Conformational Ensembles in the Cell

(2016) Guanghong Wei et al.   CHEMICAL REVIEWS

Dynamic and Electrostatic Effects on the Reaction Catalyzed by HIV-1 Protease

(2016) Agnieszka Krzemińska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase

(2016) N. Cekic et al.   Chemical Science

Carbohydrate–Aromatic Interactions in Proteins

(2015) Kieran L. Hudson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissecting conformational contributions to glycosidase catalysis and inhibition

(2014) Gaetano Speciale et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Binding Isotope Effects as a Tool for Distinguishing Hydrophobic and Hydrophilic Binding Sites of HIV-1 RT

(2014) Agnieszka Krzemińska et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Identifying the Catalytic Acid/Base in GH29 α-l-Fucosidase Subfamilies

(2013) F. Aidha Shaikh et al.   BIOCHEMISTRY

Chemical Insight into the Emergence of Influenza Virus Strains That Are Resistant to Relenza

(2013) Fahimeh S. Shidmoossavee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heavy-Enzyme Kinetic Isotope Effects on Proton Transfer in Alanine Racemase

(2013) Michael D. Toney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis

(2013) L. Y. P. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Analyses of the Reaction Coordinate of Glycosidases

(2011) Gideon J. Davies et al.   ACCOUNTS OF CHEMICAL RESEARCH

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme

(2011) R. G. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insights into glycosidase chemistry

(2008) David J Vocadlo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structural and biochemical evidence for a boat-like transition state in β-mannosidases

(2008) Louise E Tailford et al.   Nature Chemical Biology