Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine

C–H⋯S hydrogen bonding interactions

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Cellular adaptation of Clostridioides difficile to high salinity encompasses a compatible solute‐responsive change in cell morphology

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Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

(2022) Aaron L Nichols et al.   eLife

Oxidized Forms of Ergothioneine Are Substrates for Mammalian Thioredoxin Reductase

(2022) Kaelyn A. Jenny et al.   Antioxidants

Does Lactobacillus reuteri influence ergothioneine levels in the human body?

(2022) Irwin K. Cheah et al.   FEBS LETTERS

SifR is an Rrf2-family quinone sensor associated with catechol iron uptake in Streptococcus pneumoniae D39

(2022) Yifan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capturing the environment of the Clostridioides difficile infection cycle

(2022) Matthew K. Schnizlein et al.   Nature Reviews Gastroenterology & Hepatology

Interplay of the intermolecular and intramolecular interactions in stabilizing the thione-based copper(I) complexes and their significance in protecting the biomolecules against metal-mediated oxidative damage

(2022) Ashish Chalana et al.   POLYHEDRON

CIAlign: A highly customisable command line tool to clean, interpret and visualise multiple sequence alignments

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Biosynthesis of selenium-containing small molecules in diverse microorganisms

(2022) Chase M. Kayrouz et al.   NATURE

A microbial transporter of the dietary antioxidant ergothioneine

(2022) Daniel G. Dumitrescu et al.   CELL

Ergothioneine, recent developments

(2021) Irwin K. CHEAH et al.   Redox Biology

In Vitro Reconstitution of a Five-Step Pathway for Bacterial Ergothioneine Catabolism

(2021) Mariia A. Beliaeva et al.   ACS Chemical Biology

Structure- and mechanism-guided design of single fluorescent protein-based biosensors

(2021) Yusuke Nasu et al.   Nature Chemical Biology

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

The ergothioneine transporter (ETT): substrates and locations, an inventory

(2021) Dirk Gründemann et al.   FEBS LETTERS

The Pneumococcal Iron Uptake Protein a (PiuA) Specifically Recognizes Tetradentate FeIII bis- and Mono-Catechol Complexes

(2020) Yifan Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis

(2019) Hisyam Abdul Hamid et al.   Redox Biology

RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types

(2019) Gianni Monaco et al.   Cell Reports

Movement dynamics of divisome proteins and PBP2x:FtsW in cells of Streptococcus pneumoniae

(2019) Amilcar J. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regional-specific relative and absolute expression of gut transporters in adult Caucasians: A meta-analysis

(2019) Matthew Harwood et al.   DRUG METABOLISM AND DISPOSITION

DFT modeling of the prevention of Fe(II)-mediated redox damage by imidazole-based thiones and selones

(2019) Ana Dreab et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers

(2019) Marijn de Boer et al.   eLife

The role of thiols in antioxidant systems

(2019) Kathrin Ulrich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Complex Bacterial Consortia Reprogram the Colitogenic Activity of Enterococcus faecalis in a Gnotobiotic Mouse Model of Chronic, Immune-Mediated Colitis

(2019) Isabella Lengfelder et al.   Frontiers in Immunology

Selenocysteine as a substrate, an inhibitor and a mechanistic probe for bacterial and fungal iron‐dependent sulfoxide synthases.

(2019) Kristina V. Goncharenko et al.   CHEMISTRY-A EUROPEAN JOURNAL

The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways

(2019) Rémi Zallot et al.   BIOCHEMISTRY

Chemistry and Redox Biology of Mycothiol

(2018) Aníbal M. Reyes et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Ergothioneine in Microbial Physiology and Pathogenesis

(2018) Bridgette M. Cumming et al.   ANTIOXIDANTS & REDOX SIGNALING

The proteobacterial species Burkholderia pseudomallei produces ergothioneine, which enhances virulence in mammalian infection

(2018) Akshamal M. Gamage et al.   FASEB JOURNAL

Reduce, Induce, Thrive: Bacterial redox sensing during pathogenesis

(2018) Michelle L. Reniere   JOURNAL OF BACTERIOLOGY

OpuF, a New Bacillus Compatible Solute ABC Transporter with a Substrate-Binding Protein Fused to the Transmembrane Domain

(2018) Laura Teichmann et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39

(2018) Jelle Slager et al.   NUCLEIC ACIDS RESEARCH

Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

(2018) Daiana A Capdevila et al.   eLife

Isotopically-Labeled Iodoacetamide-Alkyne Probes for Quantitative Cysteine-Reactivity Profiling

(2017) Masahiro Abo et al.   MOLECULAR PHARMACEUTICS

Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis

(2016) Vikram Saini et al.   Cell Reports

Crystal Structure of the Substrate-Binding Domain from Listeria monocytogenes Bile-Resistance Determinant BilE

(2016) Stephanie Ruiz et al.   Crystals

Production of ergothioneine by Methylobacterium species

(2015) Kabir M. Alamgir et al.   Frontiers in Microbiology

Real-time conformational changes in LacY

(2014) I. Smirnova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Two Structural Domains from the PeriplasmicEscherichia coliHistidine-binding Protein HisJ

(2013) Byron C. H. Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks

(2013) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

A Density Functional Theory Investigation into the Binding of the Antioxidants Ergothioneine and Ovothiol to Copper.

(2013) Phil De Luna et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Use of knowledge-based restraints inphenix.refineto improve macromolecular refinement at low resolution

(2012) Jeffrey J. Headd et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Glutathione analogs in prokaryotes

(2012) Robert C. Fahey   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Graphical tools for macromolecular crystallography inPHENIX

(2012) Nathaniel Echols et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Streptococcus pneumoniae Uses Glutathione To Defend against Oxidative Stress and Metal Ion Toxicity

(2012) A. J. Potter et al.   JOURNAL OF BACTERIOLOGY

Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of theBacillus subtilisABC transporter OpuC

(2011) Yang Du et al.   BIOCHEMICAL JOURNAL

A structural and functional analysis of type III periplasmic and substrate binding proteins: their role in bacterial siderophore and heme transport

(2011) Byron C.H. Chu et al.   BIOLOGICAL CHEMISTRY

Cyanobacteria produce high levels of ergothioneine

(2011) Carolin Pfeiffer et al.   FOOD CHEMISTRY

The Crystal Structure of the Substrate-Binding Protein OpuBC from Bacillus subtilis in Complex with Choline

(2011) Marco Pittelkow et al.   JOURNAL OF MOLECULAR BIOLOGY

A structural classification of substrate-binding proteins

(2010) Ronnie P.-A. Berntsson et al.   FEBS LETTERS

Interplay between manganese and zinc homeostasis in the human pathogen Streptococcus pneumoniae

(2010) Faith E. Jacobsen et al.   Metallomics

Ligand Binding and Crystal Structures of the Substrate-Binding Domain of the ABC Transporter OpuA

(2010) Justina C. Wolters et al.   PLoS One

Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli

(2010) A. Gaballa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS