Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres

Telomerase inhibition on acute myeloid leukemia stem cell induced apoptosis with both intrinsic and extrinsic pathways

(2022) Ali Rafat et al.   LIFE SCIENCES

Structure of human telomerase holoenzyme with bound telomeric DNA

(2021) George E. Ghanim et al.   NATURE

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(2020) Caitlin M. Roake et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Specific stabilization of promoter G-Quadruplex DNA by 2,6-disubstituted amidoanthracene-9,10-dione based dimeric distamycin analogues and their selective cancer cell cytotoxicity

(2020) Soma Roy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Non-canonical functions of Telomerase Reverse Transcriptase – Impact on redox homeostasis

(2020) Julia Rosen et al.   Redox Biology

Anti-Proliferative and Pro-Apoptotic Effects of Short-Term Inhibition of Telomerase In Vivo and in Human Malignant B Cells Xenografted in Zebrafish

(2020) Silvia Giunco et al.   Cancers

Telomerase Inhibitor TMPyP4 Alters Adhesion and Migration of Breast-Cancer Cells MCF7 and MDA-MB-231

(2019) Natalia Konieczna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combined treatment with emodin and a telomerase inhibitor induces significant telomere damage/dysfunction and cell death

(2019) Rui Liu et al.   Cell Death & Disease

Combination Treatment with Imetelstat, a Telomerase Inhibitor, and Ruxolitinib Depletes Myelofibrosis Hematopoietic Stem Cells and Progenitor Cells

(2019) Cing Siang Hu et al.   BLOOD

Transient Telomerase Inhibition with Imetelstat Impacts DNA Damage Signals and Cell-Cycle Kinetics

(2018) Connor A.H. Thompson et al.   MOLECULAR CANCER RESEARCH

Cryo-EM structure of substrate-bound human telomerase holoenzyme

(2018) Thi Hoang Duong Nguyen et al.   NATURE

Advances in the Discovery of Anthraquinone-Based Anticancer Agents

(2018) Alexander S. Tikhomirov et al.   Recent Patents on Anti-Cancer Drug Discovery

MIM through MOM: the awakening of Bax and Bak pores

(2018) Katia Cosentino et al.   EMBO JOURNAL

Tri-armed ligands of G-quadruplex on heteroarene-fused anthraquinone scaffolds: Design, synthesis and pre-screening of biological properties

(2018) Alexander S. Tikhomirov et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Telomeres in cancer: tumour suppression and genome instability

(2017) John Maciejowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents

(2017) M. Stasevych et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin

(2016) Jigar N. Bandaria et al.   CELL

A 4:1 stoichiometric binding and stabilization of mitoxantrone-parallel stranded G-quadruplex complex established by spectroscopy techniques

(2016) Tarikere Palakashan Pradeep et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells

(2016) Andrea Celeghin et al.   Cell Death & Disease

TMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses

(2016) Xiao-Hui Zheng et al.   Scientific Reports

Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

(2016) Yang Hu et al.   Scientific Reports

Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA

(2016) Yi-Hwa Lin et al.   Scientific Reports

Telomerase reverse transcriptase in the regulation of gene expression

(2014) Junzhi Zhou et al.   BMB Reports

Pterostilbene as a Potential Novel Telomerase Inhibitor: Molecular Docking Studies and Its in vitro Evaluation

(2014) Radhika Tippani et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A

(2014) R. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual recognition of the human telomeric G-quadruplex by a neomycin–anthraquinone conjugate

(2013) Nihar Ranjan et al.   CHEMICAL COMMUNICATIONS

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

(2013) Kahlin Cheung-Ong et al.   CHEMISTRY & BIOLOGY

Novel anticancer therapeutics targeting telomerase

(2012) Maria Ruden et al.   CANCER TREATMENT REVIEWS

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel

(2009) E. M. Goldblatt et al.   MOLECULAR CANCER THERAPEUTICS

Targeting telomerase for cancer therapeutics

(2008) J W Shay et al.   BRITISH JOURNAL OF CANCER

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

(2008) Asako J Nakamura et al.   Epigenetics & Chromatin