期刊
CELL BIOCHEMISTRY AND FUNCTION
卷 33, 期 7, 页码 421-426出版社
WILEY-BLACKWELL
DOI: 10.1002/cbf.3147
关键词
HSP20; PKD1; PKA; peptide array; cardiac remodelling
资金
- Overseas Research Students Awards Scheme (ORSAS)
- Wellcome Trust [083218/Z/07/Z]
- MRC [MR/J007412/1]
- Wellcome Trust [083218/Z/07/Z] Funding Source: Wellcome Trust
- MRC [MR/J007412/1] Funding Source: UKRI
- Medical Research Council [MR/J007412/1] Funding Source: researchfish
Heat shock protein 20 (HSP20) has cardioprotective qualities, which are triggered by PKA phosphorylation. PKD1 is also a binding partner for HSP20, and this prompted us to investigate whether the chaperone was a substrate for PKD1. We delineate the PKD1 binding sites on HSP20 and show for the first time HSP20 is a substrate for PKD1. Phosphorylation of HSP20 by PKD1 is diminished by pharmacological or siRNA reduction of PKD1 activity and is enhanced following PKD1 activation. Our results suggest that both PKA and PKD1 can both phosphorylate HSP20 on serine 16 but that PKA is the most dominant. Copyright (c) 2015 John Wiley & Sons, Ltd.
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