Review
Pharmacology & Pharmacy
Sorabh Sharma, Craig E. Brown
Summary: This review discusses the relationship between microvascular dysfunction caused by type 1 diabetes and cognitive impairment, aiming to synthesize the current knowledge in this field.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Yuehong Pu, Lei Zhao, Yao Xi, Yichun Xia, Yiming Qian
Summary: The study evaluated the therapeutic effects of Mirtazapine, a central presynaptic alpha 2 receptor antagonist, on LPS-induced blood-brain barrier disruption. The results showed that Mirtazapine could protect the blood-brain barrier from LPS-induced damage and reverse the inflammatory response.
Article
Neurosciences
Anna Eskilsson, Kiseko Shionoya, David Engblom, Anders Blomqvist
Summary: The study found that fever during localized inflammation is not mediated by neural signaling, but rather relies on humoral signaling involving interleukin actions on brain endothelial cells, potentially facilitating PGE(2) entry into the brain from the circulation, representing a mechanism distinct from that during systemic inflammation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ning Gan, Ying Zhou, Jing Li, Aizhong Wang, Yiyun Cao
Summary: This study aimed to investigate the role of propofol in blood-brain barrier (BBB) damage and its underlying molecular mechanism. The results showed that propofol suppressed LPS-induced BBB damage by regulating the miR-130a-5p/ZO-1 axis. These findings provide a potential effective approach for treating BBB damage.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Neurosciences
Benjamin Villasana-Salazar, Annainaria Vezzani
Summary: Inflammatory molecules and their receptors are induced in epileptogenic foci, contributing to both the occurrence and development of seizures in drug-resistant epilepsies. Animal models have shown that activation of specific inflammatory signals in neurons or glial cells can modify seizure thresholds. Inflammatory mediators have CNS-specific neuromodulatory functions, which affect the inhibitory/excitatory balance in neural networks underlying seizures. Understanding these effects may lead to novel therapies for controlling drug-resistant seizures.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Hui Sun, Hui Li, Jie Yan, Xiangdong Wang, Mengyuan Xu, Mingxia Wang, Baozhen Fan, Jieying Liu, Ninghua Lin, Xin Wang, Li Li, Shengtian Zhao, Yongfeng Gong
Summary: Although mature podocytes lack tight junctions, the tight junction integral membrane protein claudin-5 (CLDN5) is predominantly expressed on the plasma membranes of podocytes under normal conditions. The deletion of CLDN5 exacerbates podocyte injury and proteinuria in a diabetic nephropathy mouse model by reducing ZO1 expression, inducing nuclear translocation of ZONAB, and downregulating the expression of WNT inhibitory factor-1 (WIF1).
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Karen Tse, Edward Beamer, Deborah Simpson, Robert J. Beynon, Graeme J. Sills, Thimmasettappa Thippeswamy
Summary: In experimental models, surgical implantation of intracerebral electrodes alters protein expression and levels of proinflammatory cytokines, potentially playing a role in epileptogenesis.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Fan-Cheng Kong, Li-Qin Lang, Jie Hu, Xia-Ling Zhang, Ming-Kang Zhong, Chun-Lai Ma
Summary: This study quantified and localized the expression of TET1, TET2, and 5-hydroxymethylcytosine (5-hmC) in the temporal lobe cortex of drug-resistant epilepsy (DRE) patients. It was found that TET2 expression was significantly increased in DRE patients compared to controls, and had a specific regulatory effect on ATP binding cassette subfamily B member 1 (ABCB1). These findings suggest that TET2 may serve as a potential mechanism and target in DRE.
Article
Veterinary Sciences
Erez Hanael, Shelly Baruch, Orit Chai, Zohar Nir, Kira Rapoport, Marco Ruggeri, Itzhak Eizenberg, Dana Peery, Alon Friedman, Merav H. Shamir
Summary: The study found that the permeability of the blood-brain barrier in dogs is associated with the occurrence of seizures in dogs with meningoencephalitis of unknown origin (MUO).
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Neurosciences
Jiyang Fu, Liang Li, Dong Huo, Shuli Zhi, Ruicheng Yang, Bo Yang, Bojie Xu, Tao Zhang, Menghong Dai, Chen Tan, Huanchun Chen, Xiangru Wang
Summary: The blood-brain barrier is a specialized structure that separates the brain from the bloodstream in mammals, maintaining the homeostasis of the central nervous system. Our study demonstrates the intercellular communication between astrocytes and brain microvascular endothelial cells mediated by astrocyte-derived TGF-beta1, which enhances the expression of tight junction protein ZO-1 in BMECs and improves endothelial barrier function through a non-canonical hedgehog signaling pathway.
Article
Cell Biology
Li-Xiang Yang, Yuan-Yuan Yao, Jiu-Rong Yang, Hui-Lin Cheng, Xin-Jian Zhu, Zhi-Jun Zhang
Summary: In this study, it was found that overexpression of S1P1 in neurons exacerbated blood-brain barrier disruption in epileptic mice, further promoting neuroinflammation and epilepsy-associated depression-like behaviors.
NEURAL REGENERATION RESEARCH
(2023)
Article
Clinical Neurology
Matilde Bruno, Chiara Giuseppina Bonomi, Francesco Ricci, Martina Gaia Di Donna, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Motta
Summary: This study investigated the relationship between BBB permeability and neuroinflammation in AD patients. The findings suggest that different neuroinflammatory profiles can be associated with different levels of BBB permeability in AD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Shawn Hayley, Antoine M. Hakim, Paul R. Albert
Summary: Major depression may be a precursor to cognitive decline and dementia, with chronic stress and inflammation compromising brain function and leading to depression and mild cognitive impairment. Treating inflammatory changes in depression can reverse the condition, and anti-inflammatory and antidepressant treatments may reduce or prevent dementia in individuals with depression. Chronic stress and inflammation may increase brain permeability and cytokine production, eventually manifesting as depression, cognitive impairment, and potentially dementia.
Article
Neurosciences
Juyan Zheng, Wei Zhang, PeiPei Kang, Xiaojiao Zheng, Kai He, Hong Bai, Xuerong Yu
Summary: This study found that Midazolam has a repair capacity against BBB damage induced by lipopolysaccharide (LPS), and this effect is mediated by regulating the RhoA/ROCK2 pathway.
NEUROTOXICITY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yulia Zabrodskaya, Natalia Paramonova, Anastasia Litovchenko, Elena Bazhanova, Aleksandr Gerasimov, Darya Sitovskaya, Victoria Nezdorovina, Svetlana Kravtsova, Stanislav Malyshev, Ekaterina Skiteva, Konstantin Samochernykh
Summary: Drug-resistant epilepsy (DRE) is a significant issue in neurology, and damage to the blood-brain barrier (BBB) may contribute to this resistance. In this study, the damage and dysfunction of BBB in the epileptic foci area of patients with DRE under conditions of neuroinflammation were assessed. The findings revealed overexpression of VEGF-A receptor, elevated levels of VEGF and GRO, and decreased levels of EGF in plasma. Abnormal growth of the capillary basement membrane in the brain complicates the delivery of antiepileptic drugs, which is a result of inadequate reparative processes in chronic inflammation. In conclusion, damage to the brain's microcirculatory network is a leading factor in DRE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kumaresan Ramanathan, Minale Fekadie, Giri Padmanabhan, Henok Gulilat
Summary: Long noncoding RNAs (lncRNAs) play critical roles in kidney disease development and their dysregulation can lead to various disease processes. Understanding the function and potential application of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities. This review provides an overview of lncRNA characteristics, function, and specific studies related to kidney disease treatment.
CELL BIOCHEMISTRY AND FUNCTION
(2024)
