Review
Immunology
Linda Quatrini, Biancamaria Ricci, Cecilia Ciancaglini, Nicola Tumino, Lorenzo Moretta
Summary: The neuro-endocrine system regulates immune system function and HSC differentiation through hormone release, affecting immune cell subsets. This regulation has long-term consequences during organism development, with the effects of GC exposure becoming evident in adulthood. In the context of HSCT, immune system development starts anew from donor HSCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Diana C. C. Castaneda-Cortes, Ivana F. F. Rosa, Agustin F. Boan, Demian Marrone, Natalia Pagliaro, Marcos A. A. Oliveira, Maira S. S. Rodrigues, Lucas B. B. Doretto, Camila Silva, Jose Tavares-Junior, Daniel F. F. Costa, Maria S. Dodds, Pablo H. H. Strobl-Mazzulla, Valerie S. S. Langlois, Rafael H. H. Nobrega, Juan I. I. Fernandino
Summary: Environmental changes can affect the sex determination in vertebrates, especially fish and reptiles. This study reveals the involvement of thyroid hormones (THs) and stress axis in heat-induced masculinization and female-to-male reversal. Activation of the stress axis leads to an increase in T3 levels, promoting testicular development. Understanding these endocrine processes can help predict the effects of global warming on fish populations.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Qu Deng, Reyaz Ur Rasool, Ronnie M. Russell, Ramakrishnan Natesan, Irfan A. Asangani
Summary: The study suggests a potential role of androgen in SARS-CoV-2 infection by regulating ACE2 and TMPRSS2 transcription. Camostat, a TMPRSS2 inhibitor, blocks the cleavage of SARS-CoV-2 Spike protein, providing evidence of TMPRSS2's direct role in viral fusion to host cells. Androgen-deprivation, anti-androgens, or camostat attenuate SARS-CoV-2 cellular entry, highlighting the importance of TMPRSS2 inhibitors and androgen-deprivation therapy in preventing COVID-19 progression.
Review
Oncology
Francesco Maria Venanzi, Marta Bini, Antonio Nuccio, Alessandro De Toma, Matteo Lambertini, Francesca Rita Ogliari, Sara Oresti, Maria Grazia Vigano, Elena Brioschi, Maggie Polignano, Matteo Maria Naldini, Silvia Riva, Michele Ferrara, Nicola Fogale, Giuseppe Damiano, Vincenzo Russo, Michele Reni, Giulia Veronesi, Giorgia Foggetti, Fabio Conforti, Alessandra Bulotta, Roberto Ferrara
Summary: In the era of immunoncology, there is growing evidence of a clear sex dimorphism in antitumor immune response, which could have an impact on immune checkpoint blockade (ICI) therapy in cancer patients. Pregnancy may lead to changes in the immune system, including the presence of memory T-cells with fetal antigen specificity and fetalmaternal microchimerism, which could have implications for cancer development and response to immunotherapy.
CANCER TREATMENT REVIEWS
(2023)
Article
Endocrinology & Metabolism
Victoria Persky, Chibuzor Abasilim, Konstantina Tsintsifas, Tessa Day, Robert M. Sargis, Martha L. Daviglus, Jianwen Cai, Sally Freels, Terry Unterman, Noel Chavez, Robert Kaplan, Carmen R. Isasi, Amber Pirzada, Michelle L. Meyer, Gregory A. Talavera, Bharat Thyagarajan, Brandilyn A. Peters, Jessica M. Madrigal, Arielle Grieco, Mary E. Turyk
Summary: This study examined the associations between endogenous sex hormones and diabetes progression. It found an inverse association between testosterone levels in men and conversion from prediabetes to diabetes, and an inverse association between SHBG levels in women and various glycemic measures as well as prediabetes to diabetes conversion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Ying Qian, Li Xie, Lei Li, Tienan Feng, Tengteng Zhu, Ruoyang Wang, Yuqing Yang, Baosen Zhou, Herbert Yu, Biyun Qian
Summary: This study identified an SNP rs12233719 related to SHBG concentrations that was associated with the risk of never-smoking female lung cancer, potentially explaining susceptibility to NSCLC in Chinese women.
Review
Endocrinology & Metabolism
Stuti Khadka, Sara R. Druffner, Benjamin C. Duncan, Jonathan T. Busada
Summary: Glucocorticoids are steroid hormones known for their anti-inflammatory properties, but their effects on cancer development and progression, particularly on tumor immunity, are complex and contradictory. They are commonly used alongside radiation and chemotherapy to manage symptoms but may compromise anti-tumor immunity. This review examines the impact of glucocorticoids on cancer development and progression, focusing on their modulation of pro and anti-tumor immunity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hao Wei, Annie Lee, Qing Zhang, Melanie A. Felmlee
Summary: This study evaluated the effects of exogenous sex hormones and cross-sex hormones on the expression of renal monocarboxylate transporters, finding that different hormones had different regulatory effects on the expression of MCT1, MCT4, and SMCT1.
Review
Pharmacology & Pharmacy
An Le, Kai J. Huang, Lauren R. Cirrincione
Summary: This article synthesizes available in vitro and animal model data with pharmacological concepts in transgender medicine to predict potential effects of sex steroids on drug-metabolizing enzymes and their relationship with potential hormone-drug interactions.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Janghee Lee, Hakyoung Kim, Soong June Bae, Jung Hwan Ji, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn, Joon Jeong, Sae Byul Lee, Sung Gwe Ahn
Summary: This study found that BMI may affect the 21-gene recurrence score in patients with ER-positive, ERBB2-negative breast cancer, suggesting that weight control becomes more important in the prevention and treatment of breast cancer.
Article
Pharmacology & Pharmacy
Daniela Peruzzu, Maria Teresa Pagano, Marina Pierdominici, Anna Ruggieri, Andrea Antinori, Gianpiero D'Offizi, Nicola Petrosillo, Fabrizio Palmieri, Pierluca Piselli, Evangelo Boumis, Stefania Notari, Emanuele Nicastri, Chiara Agrati, Giuseppe Ippolito, Maria Cristina Gagliardi, Maria Rosaria Capobianchi, Elena Ortona
Summary: This study evaluated the levels of circulating 25(OH)D in COVID-19 patients and found a positive correlation between 25(OH)D levels and patient's respiratory status, especially in young patients. Additionally, there was a significantly positive correlation between sex hormones and 25(OH)D in elderly patients, indicating a potential role of sex hormones in maintaining vitamin D levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Toxicology
Pengxia Yu, Yawen Chen, Caiyun Ge, Hui Wang
Summary: According to the Developmental Origin of Health and Disease (DOHaD), adverse intrauterine environments can affect fetus and birth outcomes, leading to long-term disease susceptibility with sexually dimorphic neonatal outcomes and adult disease timing and severity. The placenta, as the link between mother and fetus, exhibits sexual dimorphism in both physiological development trajectory and under pathological conditions to ensure fetal survival. The placenta may mediate sexual dimorphism in neonatal outcomes and adult disease susceptibility, with sex chromosomes, sex hormones, and glucocorticoid overexposure as key factors in placental development and regulatory mechanisms.
CRITICAL REVIEWS IN TOXICOLOGY
(2021)
Review
Oncology
Paola Matarrese, Gianfranco Mattia, Maria Teresa Pagano, Giada Pontecorvi, Elena Ortona, Walter Malorni, Alessandra Care
Summary: The study highlights the significant role of autophagy in the interaction between the tumor microenvironment and cancer cells, emphasizing the impact of gender on TME-cancer interaction and tumor growth.
Article
Endocrinology & Metabolism
Xuan Shao, Yun Yang, Yanlei Liu, Yongqing Wang, Yangyu Zhao, Xin Yu, Juan Liu, Yu-Xia Li, Yan-Ling Wang
Summary: Maintaining placental endocrine homeostasis is crucial for a successful pregnancy. Aberrant elevation of testosterone (T0) synthesis, reduced estradiol (E2), and melatonin productions have been identified in preeclamptic placentas. This study reveals an orchestrated feedback mechanism that maintains homeostasis of placental sex hormones and melatonin, and offers novel evidence that identifies potential targets for the development of innovative therapeutic strategies for PE.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Genetics & Heredity
A. Losada-Garcia, S. A. Cortes-Ramirez, M. Cruz-Burgos, M. Morales-Pacheco, Carlos D. Cruz-Hernandez, Vanessa Gonzalez-Covarrubias, Carlos Perez-Plascencia, M. A. Cerbon, M. Rodriguez-Dorantes
Summary: Neoplasic transformation is a continuous process that the immune system can recognize and suppress, but transformed cells can evade immune defenses and progress into tumors. Hormones can modulate the immune system and are involved in the pathogenesis of autoimmune diseases and cancer.
FRONTIERS IN GENETICS
(2022)