Article
Oncology
Myoung Woo Lee, Dae Seong Kim, Ji Eun Eom, Ji Won Lee, Ki Woong Sung, Hong Hoe Koo, Young Bin Hong, Keon Hee Yoo
Summary: This study evaluated the role of ERK2 and NF-kappa B in TRAIL cytotoxicity during cisplatin treatment. The findings suggest that induced ERK2 activity enhances TRAIL susceptibility via DR5 expression, while basal ERK2 activity suppresses TRAIL-R expression. The ERK2/NF-kappa B signaling pathway has a dual role in TRAIL susceptibility by differentially regulating TRAIL-R expression in the same cellular system.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang, Liangdong Li
Summary: The study found that ICT can inhibit microglial activation and M1 polarization, promote M2 polarization, and alleviate inflammatory response and achieve neuroprotection by regulating the GPER-ERK-NF-kappa B signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Oncology
Harald Krenzlin, Mykola Zdioruk, Michal O. Nowicki, Tomer Finkelberg, Naureen Keric, Niels Lemmermann, Magdalena Skubal, E. Antonio Chiocca, Charles H. Cook, Sean E. Lawler
Summary: The study suggests that the CMV-induced upregulation of c-MET may be a potential mechanism involved in the effects of CMV on GBM growth.
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Biochemistry & Molecular Biology
Qian Yuan, Kui Su, Shuyi Li, Xinyi Long, Lang Liu, Jianwu Sun, Xin Yuan, Minghui Yang, Rui Tian, Wanting Zhang, Zhujie Deng, Quanjiang Li, Changhong Ke, Yue He, Chunming Cheng, Jingna Yuan, Zhuohao Wen, Wei Zhou, Zhengqiang Yuan
Summary: The aberrantly up-regulated CDK9 can be targeted for cancer therapy. The CDK inhibitor dinaciclib (Dina) has limited selectivity, but CDK9-targeted siRNA (siCDK9) may be a good alternative. The encapsulation of siCDK9 molecules into EV-Ts to form siEV-T can efficiently suppress CDK9 expression and overcome TRAIL resistance, inducing enhanced apoptosis in lung cancer. It potentially constitutes a novel, highly effective and safe therapy for cancers.
Article
Cell Biology
Shih-Hsuan Chan, Wen-Hung Kuo, Lu-Hai Wang
Summary: A membrane-associated protein SCEL was identified through proteomic analysis, which was overexpressed in lung-tropic metastatic cells and correlated with late-stage TNBC and shorter patient survival. Knockdown of SCEL impaired colony-forming ability but not migration and invasion of the lung colonization cells. SCEL downregulation inhibited TNF-alpha-induced activation of survival and growth signaling pathways, leading to caspase 3-dependent apoptosis.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Environmental Sciences
Chiung-Ju Chen, Hung-Sheng Shang, Yuan-Li Huang, Ni Tien, Yung-Liang Chen, Sheng-Yao Hsu, Rick Sai-Chuen Wu, Chien-Lun Tang, Jin-Cherng Lien, Mei-Hui Lee, Hsu-Feng Lu, Te-Chun Hsia
Summary: We evaluated the antimetastasis activity of Bisdemethoxycurcumin (BDMC) in human glioblastoma (GBM) cells and found that BDMC may have the potential to inhibit cell migration and invasion in GBM by suppressing key signaling pathways involved in cell proliferation, uptake, and motility.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Su-Jin Lee, Da-Eun Lee, Soo-Young Choi, Oh-Shin Kwon
Summary: Levels of OGT and hyper-O-GlcNAcylation are associated with cancer pathogenesis, and combining OGT inhibitor OSMI-1 with TRAIL shows a synergistic effect in inducing apoptosis in cancer cells by increasing DR5 expression and activating ER stress response. This combination treatment inhibits NF-kappa B signaling, leading to enhanced TRAIL-induced apoptosis through caspase-8 activation in HCT116 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Victoria Granqvist, Christian Holmgren, Christer Larsson
Summary: The study demonstrates that TRAIL and Smac mimetics can induce non-canonical NF-kappa B and IFN signaling in certain breast cancer cell lines, emphasizing their potential therapeutic relevance. Phosphorylation of STAT1 is identified as a late event induced by TRAIL, independent of non-canonical NF-kappa B, and related to non-apoptotic role of caspase-8.
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dianbo Long, Yiyang Xu, Guping Mao, Ruobing Xin, Zengfa Deng, Hongyi Liao, Zhiwen Li, Zhi Yang, Baoxi Yu, Zhijian Yang, Aishan He, Ziji Zhang, Yan Kang
Summary: tRNA-derived fragments (tRFs) have been shown to play important roles in cell metabolism by regulating gene expression. This study investigates the role of tRFs in the cellular metabolism of the anterior cruciate ligament (ACL). The findings reveal that TRF365 regulates ACL cell metabolism by targeting IKBKB.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
So Rae Song, Seung Un Seo, Seon Min Woo, Ji Yun Yoon, Simmyung Yook, Taeg Kyu Kwon
Summary: In this study, the research focused on the effect of traditional Chinese medicinal herb, Tubeimoside-1 (TBMS-1), on the sensitization of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). The results showed that combination therapy using TBMS-1 and TRAIL increased apoptotic cell death. Mechanistically, TBMS-1 destabilized c-FLIP expression by downregulating STAMBPL1, a deubiquitinase (DUB). Moreover, knockdown of STAMBPL1 enhanced TRAIL-mediated apoptosis via c-FLIP downregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Zhe Yu, Yun-Yi Zhao, Ning Jiang, Ai-Zhong Zhang, Mu-Yang Li
Summary: The study found that bioflocs with a C/N ratio of 15:1 significantly promoted the growth performance of Channa argus, and could alleviate LPS-induced oxidative stress, immunosuppression, and inflammation.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yeli Zhou, Jing Li, Chenglong Wang, Zheer Pan
Summary: The study discovered that fumitremorgin C alleviates inflammation and extracellular matrix degradation induced by AGE through the activation of the SIRT1/NF-kappa B/MAPK pathway, thus preventing the progression of osteoarthritis.
Article
Plant Sciences
Hong-Ying Yang, Weidong Yao, Pei-Zhi Huang, Hui Xu, Qian Ma, Xiaoming Chen, Jian-Jun Chen, Kun Gao
Summary: This study isolated three unreported ent-abietane-type norditerpene lactones, named euphohelides A-C (1-3), from the whole plants of Euphorbia helioscopia L. The structures of euphohelides A-C were established using spectroscopic methods, computational ECD, and X-ray crystallographic analyses. Euphohelide A (1) is a novel 2-nor-ent-abietane lactone with a unique 5/6/6/5 tetracyclic system.
JOURNAL OF NATURAL PRODUCTS
(2023)