Catalytic asymmetric construction of C2-symmetric contiguous quaternary carbon centers enabled a concise synthesis of (−)-chimonanthidine and (−)-folicanthine

Dielectrophilic Allenic Ketone-Enabled [4 + 2] Annulation with 3,3’-Bisoxindoles: Enantioselective Creation of Two Contiguous Quaternary Stereogenic Centers

(2021) Xiaodong Tang et al.   ACS Catalysis

Enantioselective [4 + 2] Cycloaddition/Cyclization Cascade Reaction and Total Synthesis of cis-Bis(cyclotryptamine) Alkaloids

(2021) Jian Xu et al.   ORGANIC LETTERS

Palladium‐Catalyzed Enantioselective Heck Carbonylation with a Monodentate Phosphoramidite Ligand: Asymmetric Synthesis of (+)‐Physostigmine, (+)‐Physovenine, and (+)‐Folicanthine

(2020) Ming Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery and Total Synthesis of a Bis(cyclotryptamine) Alkaloid Bearing the Elusive Piperidinoindoline Scaffold

(2020) Jordan J. Dotson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Dearomatization/Rearomatization of 2-Nitroindoles to Access 3-Indolyl-3′-Aryl-/Alkyloxindoles: Application in the Formal Synthesis of Cyclotryptamine Alkaloids

(2020) Wei-Cheng Yuan et al.   ORGANIC LETTERS

Phosphine-Catalyzed (3+2) Annulation of Isoindigos with Allenes: Enantioselective Formation of Two Vicinal Quaternary Stereogenic Centers

(2019) Wai-Lun Chan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu(ii)–tBu–PHOX catalyzed enantioselective malonate addition onto 3-hydroxy 2-oxindoles: application in the synthesis of dimeric pyrroloindoline alkaloids

(2018) K. Naresh Babu et al.   CHEMICAL COMMUNICATIONS

Organo-Cation Catalyzed Asymmetric Homo/Heterodialkylation of Bisoxindoles: Construction of Vicinal All-Carbon Quaternary Stereocenters and Total Synthesis of (−)-Chimonanthidine

(2018) Si-Kai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiourea-Catalyzed Enantioselective Malonate Addition onto 3-Sulfonyl-3′-indolyl-2-oxindoles: Formal Total Syntheses of (−)-Chimonanthine, (−)-Folicanthine, and (+)-Calycanthine

(2018) K. Naresh Babu et al.   ORGANIC LETTERS

Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms

(2016) Martin Büschleb et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper catalyzed sequential arylation−oxidative dimerization of o-haloanilides: synthesis of dimeric HPI alkaloids

(2015) Xianfu Shen et al.   CHEMICAL COMMUNICATIONS

Catalytic Enantioselective Decarboxylative Allylations of a Mixture of Allyl Carbonates and Allyl Esters: Total Synthesis of (−)- and (+)-Folicanthine

(2015) Santanu Ghosh et al.   CHEMISTRY-A EUROPEAN JOURNAL

l-Amino Acid Based Urea–Tertiary Amine-Catalyzed Chemoselective and Asymmetric Stereoablative Carboxylation of 3-Bromooxindoles with Malonic Acid Half Thioesters

(2015) Xiangbin Bai et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (+)-Chimonanthine, (+)-Folicanthine, and (−)-Calycanthine

(2015) Ming Ding et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of naked amino-pyrroloindoline via direct aminocyclization of tryptamine

(2015) Zhigao Shen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Oxidative Dimerization of 2-Oxindoles Promoted by KOtBu-I2: Total Synthesis of (±)-Folicanthine

(2015) Santanu Ghosh et al.   ORGANIC LETTERS

Total Synthesis of (−)-Conolutinine

(2015) Xiangyang Feng et al.   ORGANIC LETTERS

CH Functionalization/Asymmetric Michael Addition Cascade Enabled by Relay Catalysis: Metal Carbenoid Used for CC Bond Formation

(2014) Dian-Feng Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thionium-Based One-Pot Construction of Homo-/Heterodimeric Pyrroloindoline from Tryptamine

(2014) Masanori Tayu et al.   ORGANIC LETTERS

Unified Synthesis of (–)-Folicanthine and (–)-Ditryptophenaline Enabled by a Room Temperature Nickel-Mediated Reductive Dimerization

(2014) Yu Peng et al.   SYNTHESIS-STUTTGART

Efficient Synthesis of 2,2,4,4,6,6-Hexanitroadamantane under Mild Conditions

(2014) Jun Luo et al.   SYNTHESIS-STUTTGART

Highly efficient and stereocontrolled oxidative coupling of tetrahydropyrroloindoles: synthesis of chimonanthines, (+)-WIN 64821 and (+)-WIN 64745

(2014) Deqian Sun et al.   Organic Chemistry Frontiers

Palladium-Catalyzed Asymmetric Construction of Vicinal All-Carbon Quaternary Stereocenters and its Application to the Synthesis of Cyclotryptamine Alkaloids

(2013) Barry M. Trost et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Bromocyclization of Tryptamines and Its Application in the Synthesis of (−)-Chimonanthine

(2013) Weiqing Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective construction of vicinal all-carbon quaternary centers via catalytic double asymmetric decarboxylative allylation

(2013) Santanu Ghosh et al.   CHEMICAL COMMUNICATIONS

Recent Developments in the Catalytic, Asymmetric Construction of Pyrroloindolines Bearing All-Carbon Quaternary Stereocenters

(2013) Lindsay M. Repka et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of Vicinal All-Carbon Quaternary Stereocenters by Catalytic Asymmetric Alkylation Reaction of 3-Bromooxindoles with 3-Substituted Indoles: Total Synthesis of (+)-Perophoramidine

(2013) Hailong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Michael Addition of Indoles to Isatylidene-3-acetaldehydes: Application to the Formal Total Synthesis of (−)-Chimonanthine

(2013) Renrong Liu et al.   ORGANIC LETTERS

Diastereoselective construction of continuous all-carbon quaternary centers via intramolecular oxidative coupling reaction

(2013) Weiqing Xie et al.   TETRAHEDRON LETTERS

Application of diazene-directed fragment assembly to the total synthesis and stereochemical assignment of (+)-desmethyl-meso-chimonanthine and related heterodimeric alkaloids

(2013) Stephen P. Lathrop et al.   Chemical Science

Catalytic Asymmetric Total Synthesis of Chimonanthine, Folicanthine, and Calycanthine through Double Michael Reaction of Bisoxindole

(2012) Harunobu Mitsunuma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iodine-mediated regioselective C2-amination of indoles and a concise total synthesis of (±)-folicanthine

(2012) Ying-Xiu Li et al.   CHEMICAL COMMUNICATIONS

Organocatalyzed Enantioselective Decarboxylative Stereoablation Reaction for the Construction of 3,3′-Disubstituted Oxindoles Using β-Ketoacids and 3-Halooxindoles

(2012) Jian Zuo et al.   JOURNAL OF ORGANIC CHEMISTRY

Total syntheses of (±)-folicanthine and (±)-chimonanthine via a double intramolecular carbamoylketene–alkene [2+2] cycloaddition

(2012) Takaaki Araki et al.   TETRAHEDRON LETTERS

ChiralN,N′-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions

(2011) XiaoHua Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Core-Structure-Oriented Asymmetric Organocatalytic Substitution of 3-Hydroxyoxindoles: Application in the Enantioselective Total Synthesis of (+)-Folicanthine

(2011) Chang Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure, Bioactivity and Synthesis of Natural Products with Hexahydropyrrolo[2,3-b]indole

(2011) Pau Ruiz-Sanchis et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Enantioselective Stereoablative Alkylation of 3-Halooxindoles: Facile Access to Oxindoles with C3 All-Carbon Quaternary Stereocenters

(2009) Sandy Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION