Review
Oncology
Yi Zhang, Hongquan Yu, Yunqian Li, Haiyang Xu, Liu Yang, Peilin Shan, Yuejiao Du, Xiaokai Yan, Xuan Chen
Summary: The infiltrative growth and malignant behavior of glioma make it a challenging brain tumor. Maximizing resection while minimizing impact on normal tissue is the goal of neurosurgeons. Current visualization techniques have drawbacks, while Raman spectroscopy offers non-destructive, rapid, and accurate intraoperative glioma identification. This article summarizes the latest research on Raman spectroscopy in glioma surgery.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yuanzheng Hou, Ye Li, Qiongge Li, Yang Yu, Jie Tang
Summary: In this study, the authors retrospectively reviewed the use of intraoperative ultrasound (iUS) and intraoperative MRI (iMRI) in a full-course resection control strategy for initial glioma surgeries. The results showed that this strategy can achieve good surgical outcomes and may improve efficiency by reducing the number of iMRI scans and shortening surgery time.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Keith Simfukwe, Iurii Iakimov, Rinat Sufianov, Luis Borba, Luciano Mastronardi, Alina Shumadalova
Summary: This study documents the use of intraoperative ultrasonography (iUS) as a primary navigational tool in neurosurgery cases and discusses its advantages compared to other neuronavigation techniques.
FRONTIERS IN SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Weidong Zhao, Jinming Li, Zhenjie Xue, Xuezhi Qiao, Ailin Li, Xiangyu Chen, Yun Feng, Zhou Yang, Tie Wang
Summary: A binary nanosphere array with dual properties was constructed as a separation-sensing platform for the diagnosis of target molecules in tears. This platform enables tear collection, pre-separation, and detection, and successfully identifies patients with jaundice.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Kedong Gong, Robin Raffe Jones, Kejian Li, Guanjun Xu, Hanyun Cheng, Yiqing Feng, Ventsislav Kolev Valev, Liwu Zhang
Summary: The study developed a method to directly measure the pH of microdroplets using Surface Enhanced Raman Scattering technology. It establishes the relationship between microdroplet size and pH value, and showcases the potential application in environmental samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemical Research Methods
Hui Chen, Caixia Luo, Shangtao Zhang
Summary: Exosomes have been highly studied for their potential as cancer diagnostic targets and therapeutic agents. A new method using SERS technology has been demonstrated for imaging exosomes intracellularly and sensing pH simultaneously. This technique allows for tracking exosomal distribution within cells and quantitative pH sensing, providing insights into interactions between exosomes and cells.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Spectroscopy
Yue Zhang, Ji Zhou, Ying He, Yong Ye, Jing An
Summary: Functional composite fibers prepared by wet-spinning method were used for pH sensing based on surface enhanced Raman scattering (SERS). The fibers showed distinct SERS enhancement for low concentrations of dyes and pH dependent SERS spectra. The flexible composite fibers could be woven into a wearable wrist band for health monitoring.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Multidisciplinary
Yuanjiao Yang, Shan Wu, Yunlong Chen, Huangxian Ju
Summary: The detection and mapping of cellular biomarkers is crucial for understanding physiological and pathological processes. SERS technology, with its high sensitivity and multiplex detection capabilities, has emerged as a powerful tool for this purpose.
Article
Nanoscience & Nanotechnology
Qiang Zhang, Tomoko Inose, Monica Ricci, Jiangtao Li, Ya Tian, Han Wen, Shuichi Toyouchi, Eduard Fron, Anh Thi Ngoc Dao, Hitoshi Kasai, Susana Rocha, Kenji Hirai, Beatrice Fortuni, Hiroshi Uji-I
Summary: Gold-deposited silver nanowire endoscopy is a promising tool for studying pH variations in cells, with high spatiotemporal resolution and sensitivity, by accurately detecting specific pH changes in response to different treatments.
ACS APPLIED NANO MATERIALS
(2021)
Article
Engineering, Environmental
Yen-Hsiang Huang, Hong Wei, Peter J. Santiago, William John Thrift, Regina Ragan, Sunny Jiang
Summary: Rapid and cost-effective detection of antibiotics in wastewater and through wastewater treatment processes is crucial. Surface-enhanced Raman scattering (SERS) has the potential for label-free, real-time sensing of antibiotic contamination in the environment. This study tested two gold nanostructures as SERS substrates for the label-free detection of quinoline, a commonly found antibiotic in wastewater.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Yen-Hsiang Huang, Hong Wei, Peter J. Santiago, William John Thrift, Regina Ragan, Sunny Jiang
Summary: Rapid and cost-effective detection of antibiotics in wastewater is crucial for effective strategies in their removal. Surface-enhanced Raman scattering (SERS) can potentially provide label-free, real-time sensing of antibiotic contamination. This study tested two gold nanostructures as SERS substrates for the detection of quinoline, a commonly found antibiotic in wastewater. Results showed that the self-assembled SERS substrate had a low limit of detection (LoD) of 5.01 ppb for quinoline in wastewater. However, the commercially available SERS substrate performed poorly due to interference from non-target molecules.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ruiqi Cai, Jingfeng Tang, Xing-Zhen Chen
Summary: The hydrophobicity of site 304 is crucial for maintaining PAC in a closed state at pH 7.5, while the hydrophilicity of site 307 significantly increases PAC activity when activated at acidic pH, indicating that 307 acts as an activation gate.
Review
Physics, Condensed Matter
Gautam Reddy, Venkatesh N. Murthy, Massimo Vergassola
Summary: This article discusses the impact of fluid turbulence on the navigation of birds, insects, and rodents, as well as its direct influence on animal behavior. The article also summarizes the functions of olfactory organs and the computational tasks animals face when extracting information from olfactory signals.
ANNUAL REVIEW OF CONDENSED MATTER PHYSICS
(2022)
Article
Oncology
Junlong Wang, Hua Zhang, Xuefei Dang, Wenting Rui, Haixia Cheng, Jing Wang, Yong Zhang, Tianming Qiu, Zhenwei Yao, Hanqiu Liu, Haopeng Pang, Yan Ren
Summary: This study investigated the correlation between multi-b-value diffusion-weighted imaging and pathological features in patients with glioma. The results showed that certain parameters were closely related to blood vessel density and cell proliferation. This research has important implications for understanding the pathological correlations of gliomas.
FRONTIERS IN ONCOLOGY
(2023)
Review
Chemistry, Analytical
Lei Zhang, Qianqian Zhao, Zhitao Jiang, Jingjing Shen, Weibing Wu, Xingfen Liu, Quli Fan, Wei Huang
Summary: The article discusses the working mechanism and design of pH SERS sensors, as well as the importance and influencing factors of related applications; it also describes the applications of pH probes in intracellular and extracellular pH imaging and in combination with other techniques, and presents the outlook for future development.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).