Article
Neurosciences
Yuhualei Pan, Dan Tian, Huan Wang, Yushang Zhao, Chengjie Zhang, Song Wang, Dan Xie, Dong Zhang, Yanbing Zhu, Yongbo Zhang
Summary: The research revealed that perforin-mediated neurotoxicity plays a critical role in the ischemic brain, indicating that targeting perforin-mediated neurotoxicity in brain-resident microglia and invading perforin(+)CD45(+) immune cells may be a potential strategy for the treatment of ischemic stroke.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Joana Martins-Macedo, Antonio J. Salgado, Eduardo D. Gomes, Luisa Pinto
Summary: Psychiatric disorders have a significant impact on patients' lives, with common symptoms including motivational, cognitive and emotional deficits. Current treatments are often ineffective due to adverse side effects or low efficacy rates. Understanding neuro-and gliogenesis mechanisms is crucial for defining effective treatments, as they play a key role in cognitive and emotional behavior.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Shengming Wang, Yu Fu, Takaki Miyata, Sakiko Matsumoto, Tomoyasu Shinoda, Kyoko Itoh, Akihiro Harada, Shinji Hirotsune, Mingyue Jin
Summary: This study reveals the functional cooperation between aSyn and tau during brain development. Deletion of aSyn and tau alters the balance between progenitor cell proliferation and neurogenesis, resulting in an overproduction of early born neurons. Furthermore, there is a reduction in neural progenitor cells in the aSyn-/-tau-/- cortex, leading to diminished gliogenesis. Additionally, expansion and maturation of macroglial cells are suppressed in the aSyn-/-tau-/- postnatal brain, resulting in reduced brain size and cortical thickness.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Immunology
Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Chen
Summary: This review explores the roles of adult hippocampal neurogenesis and microglia in the etiology of depression, and discusses the mechanisms by which microglia regulate adult hippocampal neurogenesis in depression and potential drugs for improving neurogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Amadi Ogonda Ihunwo, Jessica Perego, Gianvito Martino, Elisa Vicenzi, Paola Panina-Bordignon
Summary: Neural stem cells play a crucial role in the brain, being able to self-renew and differentiate into neurons. They are regulated by signals from the local and distant environment. Zika virus and severe acute respiratory syndrome coronavirus 2 may cause damage to neural stem cells and the brain.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Yuanyuan Huang, Wuxiang Sun, Fujia Gao, Haoran Ma, Tao Yuan, Zixuan Liu, Huiyu Liu, Jiewei Hu, Jing Bai, Xin Zhang, Ruimin Wang
Summary: This study aimed to explore the role of brain-derived estrogen (BDE2) in hippocampal neurogenesis with aging in female rats. The results showed that cell differentiation declined over middle age, while the differentiation of astrocytes and microglia markedly increased. Female forebrain neuronal aromatase knockout (FBN-ARO-KO) rats exhibited declined neurogenesis and cognitive impairment compared to WT controls. The study suggests that BDE2 plays a key role in maintaining hippocampal neurogenesis and cognitive function.
Review
Cell Biology
Werend Boesmans, Amelia Nash, Kinga R. Tasnady, Wendy Yang, Lincon A. Stamp, Marlene M. Hao
Summary: Enteric glia are support cells of the enteric nervous system that play a vital role in regulating gut functions and maintaining homeostasis. Their plasticity and heterogeneity make them neural precursors with the potential for neurogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kaoru Tominaga, Eiji Sakashita, Katsumi Kasashima, Kenji Kuroiwa, Yasumitsu Nagao, Naoki Iwamori, Hitoshi Endo
Summary: Epigenetic factors play a crucial role in establishing functional organ systems during development, including brain development. However, the precise mechanism of epigenetic regulation in brain development and neurogenesis remains largely unknown. In this study, the researchers discovered the critical role of the Tip60 protein in brain development and the maintenance and function of neural stem/progenitor cells (NSCs). Tip60 deficiency led to multiple abnormalities in brain development, including microcephaly, reduced proliferation of developing brain cells, and impaired neural differentiation and migration. The study also revealed that Tip60 is involved in the transition from neurogenesis to gliogenesis during brain development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Samantha N. Lanjewar, Steven A. Sloan
Summary: Research on human glial development and their role in neurodevelopmental disorders utilizes novel 2D cell culture protocols, 3D organoid models, and bioengineered systems derived from human stem cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hitomi Matsuno, Shoko Tsuchimine, Kazunori O'Hashi, Kazuhisa Sakai, Kotaro Hattori, Shinsuke Hidese, Shingo Nakajima, Shuichi Chiba, Aya Yoshimura, Noriko Fukuzato, Mayumi Kando, Megumi Tatsumi, Shintaro Ogawa, Noritaka Ichinohe, Hiroshi Kunugi, Kazuhiro Sohya
Summary: Several lines of evidence suggest that stress-induced neurovascular dysfunction and increased blood-brain barrier permeability are important pathological links between stress and psychiatric disorders. This study demonstrates the crucial role of vascular endothelial growth factor in stress-induced blood-brain barrier dysfunction and depressive-like behavior development.
MOLECULAR PSYCHIATRY
(2022)
Review
Neurosciences
Fiorenza Stagni, Renata Bartesaghi
Summary: Down syndrome is a genetic disorder caused by triplication of Chromosome 21, leading to intellectual impairment and potential development of Alzheimer's disease. Research on DS suggests that pharmacological interventions during the embryonic period can have significant benefits for brain development and cognitive abilities. This review provides a comprehensive summary of the neurogenesis and dendritic changes in DS throughout different stages of life, aiming to identify potential therapeutic targets and explore the possibility of fetal therapy for individuals with DS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Environmental Sciences
Chunyan Yao, Xiaoling Liu, Yan Tang, Chunmei Wang, Chenggang Duan, Xiaoyan Liu, Mingliang Chen, Yumeng Zhou, Enjie Tang, Ying Xiang, Yafei Li, Ailing Ji, Tongjian Cai
Summary: Microglia-mediated neuroinflammation is crucial in the pathophysiology of neurodegenerative diseases. Lipopolysaccharide (LPS) can activate microglia and induce inflammation. Matrix metalloproteinases (MMPs) and CD147 are key factors involved in microglial activation and inflammation. This study found that CD147 expression was induced in LPS-induced microglial activation, and inhibiting CD147 expression could suppress microglial activation. Furthermore, MMPs and autophagy were involved in the inflammatory activation of microglia, and inhibiting MMPs or autophagy could attenuate this activation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Youtong Huang, Greg Lemke
Summary: Recurrent seizures, which may contribute to the pathogenesis and cognitive decline of Alzheimer's disease, are common in early-stage AD and mouse models that overproduce amyloid beta. In a study of the APP/PS1 mouse model, it was found that the mutation of TAM receptor tyrosine kinase (RTK) Mer or its ligand Gas6 significantly increased the risk of early death, which was tied to violent seizures originating in the dentate gyrus of the hippocampus. TAM-deficient mice showed increased newborn DG neurons and excitatory synapses, coinciding with premature death and adult neurogenesis. In contrast, the incidence of lethal seizures was strongly anticorrelated with the deposition of dense-core amyloid plaques. These findings suggest that TAM-mediated phagocytosis influences synaptic connectivity in the hippocampus and that seizure-inducing amyloid beta polymers are present before the formation of dense-core plaques.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Hyeri Im, In Gyoung Ju, Jin Hee Kim, Seungmin Lee, Myung Sook Oh
Summary: This study found that PNP001 can inhibit neuroinflammation and neurological deficits induced by LPS. In both in vitro and in vivo experiments, PNP001 reduced the release of inflammatory cytokines, alleviated microglial activation and synaptic loss. Furthermore, PNP001 significantly improved memory decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Chiara Galante, Nicolas Marichal, Franciele Franco Scarante, Litsa Maria Ghayad, Youran Shi, Carol Schuurmans, Benedikt Berninger, Sophie Peron
Summary: The proneural transcription factor Ascl1 is involved in neural fate decisions. It has been widely used to reprogram non-neuronal cells into neurons in vitro. However, this study found that, in vivo, Ascl1 only had very low efficiency in inducing neuronal reprogramming of glial cells in the postnatal mouse cerebral cortex. Instead, Ascl1 selectively enhanced the proliferation of oligodendrocyte progenitor cells (OPCs).
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Yuumi Kobayashi, Ronan da Silva, Haruko Kumanogoh, Shinji Miyata, Chihiro Sato, Ken Kitajima, Shun Nakamura, Mistuhiro Morita, Fumio Hayashi, Shohei Maekawa
JOURNAL OF NEUROSCIENCE RESEARCH
(2015)
Article
Pharmacology & Pharmacy
Mitsuhiro Morita, Akira Nakane, Shohei Maekawa, Yoshihisa Kudo
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2015)
Article
Neurosciences
Shohei Maekawa, Yuumi Kobayashi, Mitsuhiro Morita, Toshinobu Suzaki
NEUROSCIENCE LETTERS
(2015)
Article
Multidisciplinary Sciences
Mitsuhiro Morita, Akira Nakane, Yuki Fujii, Shohei Maekawa, Yoshihisa Kudo
Article
Biochemistry & Molecular Biology
Kunihiko Yamashiro, Yuki Fujii, Shohei Maekawa, Mitsuhiro Morita
JOURNAL OF NEUROCHEMISTRY
(2017)
Article
Immunology
Shohei Takagi, Eriko Furube, Yousuke Nakano, Mitsuhiro Morita, Seiji Miyata
JOURNAL OF NEUROIMMUNOLOGY
(2019)
Review
Cell Biology
Kunihiko Yamashiro, Mitsuhiro Morita
NEURAL REGENERATION RESEARCH
(2017)
Article
Immunology
Daishi Hiratsuka, Eriko Furube, Katsutoshi Taguchi, Masaki Tanaka, Mitsuhiro Morita, Seiji Miyata
JOURNAL OF NEUROIMMUNOLOGY
(2018)
Article
Neurosciences
Satoko Ueno, Hiroshi Miyoshi, Yoko Maruyama, Mitsuhiro Morita, Shohei Maekawa
NEUROSCIENCE LETTERS
(2018)
Article
Neurosciences
Yoko Maruyama, Satoko Ueno, Mitsuhiro Morita, Fumio Hayashi, Shohei Maekawa
NEUROSCIENCE LETTERS
(2018)
Article
Multidisciplinary Sciences
Yuki Fujii, Shohei Maekawa, Mitsuhiro Morita
SCIENTIFIC REPORTS
(2017)
Review
Biochemistry & Molecular Biology
Mitsuhiro Morita, Hiroko Ikeshima-Kataoka, Marko Kreft, Nina Vardjan, Robert Zorec, Mami Noda
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Eriko Furube, Haruna Ishii, Yuri Nambu, Erkin Kurganov, Sumiharu Nagaoka, Mitsuhiro Morita, Seiji Miyata
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Medicinal
Yuki Sakai, Yukiko Asakura, Mitsuhiro Morita, Takashi Takahashi
CHEMICAL & PHARMACEUTICAL BULLETIN
(2017)