Review
Pharmacology & Pharmacy
Akhgar Ghassabian, Laura Vandenberg, Kurunthachalam Kannan, Leonardo Trasande
Summary: This article discusses the unique vulnerability of children to endocrine-disrupting chemicals (EDCs) and the programming effects of EDCs on neuronal, metabolic, immune, endocrine, reproductive, and renal systems. By dispelling myths and providing a list of actions to reduce exposure and harm, it aims to address the health effects of EDCs on child health.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Article
Environmental Sciences
Viviana Ramirez, Yolanda Galvez-Ontiveros, Pablo Jose Gonzalez-Domenech, Miguel Angel Baca, Lourdes Rodrigo, Ana Rivas
Summary: The study aimed to review limited literature on the effects of postnatal exposure to EDC on child neurodevelopment and behavior. While some research suggests a relationship between postnatal EDC exposure and adverse neurobehavioral outcomes in children, the underlying mechanisms of action remain unclear.
ENVIRONMENTAL RESEARCH
(2022)
Review
Reproductive Biology
Maura S. McGraw, Bradford W. Daigneault
Summary: The exposure of livestock embryos to environmental contaminants may have detrimental effects on their development, but this area of research is still not well understood. The relationship between the environment and reproductive function has been carefully developed in agriculture production, particularly in terms of nutrient and resource management. Exposure to environmental toxicants through pesticides and industrial practices has been linked to a decline in fertility in cattle and humans. Understanding the consequences of livestock exposure to environmentally relevant levels of contaminants on embryo development is important, especially with the increasing use of agricultural animals for biomedical models. Additionally, there is a need to define environmental interactions from gamete to genome, considering both genetic and nongenetic factors.
BIOLOGY OF REPRODUCTION
(2022)
Review
Endocrinology & Metabolism
Angelica Amorim Amato, Hailey Brit Wheeler, Bruce Blumberg
Summary: Obesity has become a global pandemic, with traditional explanations pointing to high-calorie diets and lack of exercise. However, the presence of endocrine-disrupting chemicals (EDCs) in the environment may also be a significant factor contributing to the increasing rates of obesity worldwide.
ENDOCRINE CONNECTIONS
(2021)
Review
Endocrinology & Metabolism
Emily N. Hilz, Andrea C. Gore
Summary: Exposure to endocrine-disrupting chemicals (EDCs) during developmental periods can lead to sex-specific changes in the brain's monoaminergic systems (dopamine, serotonin, norepinephrine), potentially affecting cognition such as affective, attentional, and learning/memory behaviors.
Article
Environmental Sciences
Katherine Svensson, Chris Gennings, Christian Lindh, Hannu Kiviranta, Panu Rantakokko, Sverre Wikstrom, Carl-Gustaf Bornehag
Summary: This study found an association between prenatal exposure to a mixture of EDCs and lower BMI and overweight in girls, with non-significant associations among boys. Chemicals of concern for girls included phthalates, non-phthalate plasticizers, bisphenols, PAHs, and PFAS.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Toxicology
Chaitanya K. Jaladanki, Yang He, Li Na Zhao, Sebastian Maurer-Stroh, Lit-Hsin Loo, Haiwei Song, Hao Fan
Summary: The study proposed a virtual screening method based on molecular docking to predict potential endocrine-disrupting chemicals that bind to nuclear receptors. By analyzing the discriminating power of multiple structures for NRs and optimizing the strategy with a chemical similarity-weighted scoring scheme, several fatty acids were screened as potential EDCs.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Environmental Sciences
Tian Tian, Yongxiu Hao, Yuanyuan Wang, Xiaofei Xu, Xiaoyu Long, Liying Yan, Yue Zhao, Jie Qiao
Summary: Endocrine-disrupting chemicals (EDCs) are widely spread pollutants that have raised concerns about their impacts on reproductive health. Diminished ovarian reserve (DOR) is a disorder of ovarian function, and the association between EDCs and DOR has been inconsistent. In this study, we found that the likelihood of DOR significantly increased with rising levels of a mixture of 21 EDCs, and specific chemicals within the mixture were driving this association. These findings emphasize the importance of considering the effects of EDC mixtures on female reproductive health.
Article
Biochemistry & Molecular Biology
Polina Lizunkova, Elin Engdahl, Gabor Borbely, Chris Gennings, Christian Lindh, Carl-Gustaf Bornehag, Joelle Ruegg
Summary: The study investigates the adverse effects of a mixture of endocrine disrupting chemicals (EDCs) on human cells and genes. The mixture, derived from data in the SELMA study, was found to induce lipid droplet accumulation and DNA methylation changes. These findings suggest that real-life exposure to EDCs can lead to molecular and cellular changes that may result in adverse outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
J. Chanemougavally, Balaji Thotakura, K. M. Shruthy, C. S. Janaki
Summary: This review article focuses on the harmful effects of endocrine-disrupting chemicals (EDCs), particularly bisphenol A (BPA), on the skeletal system during embryonic development. It discusses the impact of BPA on the formation of bone cells and highlights the potential long-term effects on immune system development.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Education & Educational Research
Emily N. Hilz, Andrea C. Gore
Summary: Endocrine-disrupting chemicals are substances that interfere with the normal functioning of hormones in the endocrine system, causing adverse health effects in humans and wildlife. Current regulations on EDCs face challenges due to limited understanding of their complex dose-response relationships and difficulty in attributing specific health effects to individual EDC exposures. There is a need for more comprehensive testing requirements and robust regulatory frameworks to address the diversity and complexity of EDCs and their cumulative effects.
POLICY INSIGHTS FROM THE BEHAVIORAL AND BRAIN SCIENCES
(2023)
Review
Endocrinology & Metabolism
Soner Cander, Ilhan Yetkin
Summary: The incidence of obesity and type 2 diabetes mellitus is increasing globally. Certain chemicals, known as endocrine-disrupting chemicals (EDCs), have been found to play a potential role in the pathophysiological mechanisms of these conditions. EDCs can impair hormonally regulated metabolic processes and may contribute to weight gain and glucose metabolism disorders.
ENDOCRINOLOGY RESEARCH AND PRACTICE
(2023)
Article
Engineering, Environmental
Leslie B. Hart, Mary Lightsey, Kristy Johnson, Jack Golder, Mary Beth Vassy, Beth Sundstrom
Summary: Personal care products (PCPs) containing endocrine-disrupting chemical additives (EDCs) can have adverse effects on human health. This study compared PCP use between students from two universities and found that female students used more PCPs, increasing their risk of EDC exposure.
JOURNAL OF HAZARDOUS MATERIALS ADVANCES
(2022)
Article
Multidisciplinary Sciences
Marcia Rocha, Rachel Arcanjo, Claudio Lopes, Marcella Carneiro, Aparecido Souza, Sonia Bao
SCIENTIFIC REPORTS
(2017)
Article
Anatomy & Morphology
Rachel B. Arcanjo, Leonardo P. de Souza, Carla F. Rezende, Jose R. F. Silva
Article
Agriculture, Multidisciplinary
Rachel B. Arcanjo, Kadeem A. Richardson, Shuhong Yang, Shreya Patel, Jodi A. Flaws, Romana A. Nowak
Summary: The study found that chronic intake of genistein may have an impact on the uterus of mice, but does not cause persistent harm to the organ.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Environmental Sciences
Shah Tauseef Bashir, Karen Chiu, Eileen Zheng, Angel Martinez, Justin Chiu, Kishori Raj, Sandra Stasiak, Nastasia Zhen Ee Lai, Rachel B. Arcanjo, Jodi A. Flaws, Romana A. Nowak
Summary: DEHP exposure has differential effects on the ileum and colon, altering colonic morphology and the intestinal immune microenvironment.
Article
Cell Biology
Hyojeong Hwang, Seongmin Yun, Rachel Braz Arcanjo, Divyanshi, Sijie Chen, Wenyan Mei, Romana A. Nowak, Taejoon Kwon, Jing Yang
Summary: This study reveals that, in Xenopus oocytes, the majority of ER-associated RNA-binding proteins (RBPs) remain associated with the ER after oocyte maturation but exhibit reduced binding to some target RNAs. The study also demonstrates that the ER undergoes massive remodeling during oocyte maturation, leading to the formation of a widespread tubular ER network in the animal hemisphere that is required for the asymmetric localization of mRNAs in mature eggs.
Article
Immunology
Shah Tauseef Bashir, Catherine R. R. Redden, Kishori Raj, Rachel B. B. Arcanjo, Sandra Stasiak, Quanxi Li, Andrew J. J. Steelman, Romana A. A. Nowak
Summary: This study aimed to investigate the central nervous system-wide glial activation in a mouse model of endometriosis and its implications on chronic pain, anxiety, and depression in women with endometriosis.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Agriculture, Dairy & Animal Science
Ramon Cesar Botigelli, Carly Guiltinan, Rachel Braz Arcanjo, Anna Carolina Denicol
Summary: Pluripotent stem cells (PSC) can be obtained from embryos or adult somatic cells, and significant progress has been made in the livestock PSC field, including long-term culture and understanding cellular pluripotency. The germline is particularly important as it plays a crucial role in reproduction, and in vitro gametogenesis (IVG) could have significant implications for agriculture and reproduction. Many studies have been done on IVG in rodents, and this review discusses the current progress and challenges in livestock IVG.
JOURNAL OF ANIMAL SCIENCE
(2023)
Review
Reproductive Biology
Shuhong Yang, Rachel Braz Arcanjo, Romana A. Nowak
Summary: DiNP is a high molecular weight, general purpose plasticizer used in the manufacture of polymers and consumer products. Studies show negative effects on ovarian function and fertility in female animal models, while male studies indicate disruptive effects on male reproduction and fertility. Controversy remains regarding direct effects on the uterus, highlighting the need for further research on human reproduction effects.
BIOLOGY OF REPRODUCTION
(2021)
Article
Agriculture, Dairy & Animal Science
R. Arcanjo, M. Rocha, M. Marques, M. F. Almeida-Santos, S. N. Bao
ANIMAL REPRODUCTION
(2016)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)