Article
Genetics & Heredity
Manyu Zhang, Chunyu Liu, Beili Chen, Mingrong Lv, Huijuan Zou, Yajing Liu, Yang Gao, Tianjuan Wang, Qiong Xing, Yutong Zhu, Huan Wu, Zhiguo Zhang, Ping Zhou, Zhaolian Wei, Xiaojin He, Yuping Xu, Yunxia Cao
Summary: Preimplantation embryonic lethality caused by TLE6 gene variants has been identified in 14.29% of patients, leading to lower expression of the TLE6 protein in oocytes. This study extends the genetic spectrum of female infertility and highlights the essential role of TLE6 in early embryonic development. Oocyte donation may be a preferred treatment option in such cases.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Hye Youn Sung, Eun Nam Choi, Jihye Han, Yun Ju Chae, Sun-Wha Im, Hee-Sun Kim, Eun-Mi Park, Jung-Hyuck Ahn
Summary: Research suggests that ischemic preconditioning reduces brain ischemia-reperfusion injury by downregulating the expression of miR-33-5p and miR-135b-5p, which in turn protects neurons from apoptosis induced by oxygen-glucose deprivation. Inhibition of these two miRNAs significantly increases mRNA and protein levels of ABCA1 and reduces activation of the mitochondria-dependent apoptosis pathway.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Juan Francisco Aranda, Ana Perez-Garcia, Marta Torrecilla-Parra, Mario Fernandez-de Frutos, Yolanda Martin-Martin, Pedro A. Mateos-Gomez, Virginia Pardo-Marques, Rebeca Busto, Cristina M. Ramirez
Summary: Hypoxia plays a crucial role in the maintenance of atherosclerotic lesions. miR-199a-5p and ABCA1 are inversely regulated by hypoxia and Ac-LDL, and their interaction can control macrophage cholesterol efflux during the onset of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Shrey Kohli, Kunal Kumar Singh, Anubhuti Gupta, Paulina Markmeyer, Franziska Lochmann, Dheerendra Gupta, Rajiv Rana, Ahmed Elwakiel, Hanna Huebner, Matthias Ruebner, Berend Isermann
Summary: The study revealed a unidirectional interaction between placental inflammasome activation and reduced placental TM expression, and demonstrated that soluble TM treatment or placental TM restoration can alleviate PE-like symptoms.
Article
Biochemistry & Molecular Biology
Zhexiao Zhang, Yunmei Qiu, Wanzhi Li, Anyang Tang, Hang Huang, Wanyi Yao, Huawen Li, Tangbin Zou
Summary: It is widely believed that the deposition of foam cells in the arterial wall is the main cause of atherosclerosis. However, our experimental results suggest that astaxanthin can promote cholesterol efflux by modulating ATP-binding cassette subfamily A member 1, thereby inhibiting foam cell formation and preventing the occurrence and development of atherosclerosis.
Article
Cell Biology
Fei Xu, Li Shen, Han Chen, Rui Wang, Tongtong Zang, Juying Qian, Junbo Ge
Summary: Inflammation plays a crucial role in atherosclerosis, and circRNA circDENND1B has been identified as a novel mediator of atherosclerosis in mice. Upregulation of circDENND1B alleviates foam cell formation and promotes cholesterol efflux, suggesting its potential as a therapeutic target in atherosclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marcelo T. Moura, Lais B. Latorraca, Fabiola E. Paula-Lopes
Summary: Mammals have developed mechanisms to cope with environmental stressors throughout their lifespan, including the autophagy pathway, which helps repair damage and reallocates resources for long-term survival. Autophagy plays a key role in mammalian gametogenesis, fertilization, and preimplantation embryonic development, affecting physiological processes and responses to stressors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Erika E. Paulson, Emily L. Fishman, Richard M. Schultz, Pablo J. Ross
Summary: MicroRNAs play a crucial role in preimplantation embryo development, with their expression increasing during the morula and blastocyst stages. Knockdown of DGCR8 inhibits the expression of embryonically expressed miRNAs and the morula-to-blastocyst transition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jere P. Segrest, Chongren Tang, Hyun D. Song, Martin K. Jones, W. Sean Davidson, Stephen G. Aller, Jay W. Heinecke
Summary: By using simulations, the authors of this study uncover the mechanism by which ATP-binding cassette transporter A1 (ABCA1) functions in extracting lipids from the outer face of the plasma membrane and facilitating the production of high density lipoprotein (HDL). Contrary to existing models, their findings suggest that ABCA1 removes lipids from the plasma membrane and forces them through its gateway and annulus into an elongated hydrophobic tunnel. This study provides important insights into the function of ABCA1 and presents a potential target for further research.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Lei Chen, Zhen-Wang Zhao, Peng-Hui Zeng, Ying-Jie Zhou, Wen-Jun Yin
Summary: The maintenance of cellular cholesterol homeostasis is crucial for normal cell function and viability. Excessive cholesterol accumulation is the molecular basis of many diseases. Peripheral cells eliminate excessive cholesterol through cholesterol efflux, which is mainly mediated by ATP-binding cassette transporter A1 (ABCA1). This article focuses on the mechanisms underlying ABCA1-mediated cholesterol efflux, providing important insights for future investigation and lipid-lowering therapy.
Review
Health Care Sciences & Services
Jing Wang, Qianqian Xiao, Luyun Wang, Yan Wang, Daowen Wang, Hu Ding
Summary: ABCA1 plays a significant role in cholesterol homeostasis and inflammation inhibition, and decreased expression of ABCA1 is associated with an increased risk of cardiovascular diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Cheng Zhang, Xuewen Wu, Pengmin Shi, Hongyu Ma, Fei Fang, Qianlang Feng, Shuang Zhao, Ruipu Zhang, Jinyuan Huang, Xinting Xu, Weilie Xiao, Guang Cao, Xu Ji
Summary: In this study, it was found that diterpenoids from the traditional Chinese medicine Callicarpa rubella could effectively inhibit oxidized low-density lipoprotein-induced macrophage foam cell formation by promoting cholesterol efflux, suggesting their potential as drugs for the treatment of atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hong Y. Choi, Senna Choi, Iulia Iatan, Isabelle Ruel, Jacques Genest
Summary: ATP-binding cassette transporter A1 (ABCA1) is a molecular defect in Tangier disease, characterized by the absence of high-density lipoprotein cholesterol (HDL-C) in the circulation and the accumulation of cholesterol in lymphoid tissues. Atherosclerosis is caused by the accumulation of cholesterol in arteries, while HDL-C levels are inversely associated with the presence of atherosclerotic cardiovascular disease (ASCVD). Strategies to increase ABCA1 expression and activity have been studied to reduce ASCVD, but no successful clinical trials have been conducted yet. This review discusses the current understanding, challenges, and future directions in ABCA1 research for developing therapies for ASCVD.
Article
Medicine, Research & Experimental
Ignacio Fernando Hall, Montserrat Climent, Chiara Viviani Anselmi, Laura Papa, Vinicius Tragante, Luca Lambroia, Floriana Maria Farina, Marcus E. Kleber, Winfried Maerz, Carlo Biguori, Gianluigi Condorelli, Leonardo Elia
Summary: The study identifies a SNP, rs41291957 (A), near the miR-143/145 cluster that upregulates miR-143 and miR-145, modulating vascular smooth cell phenotype and acting as a protective factor against coronary artery disease.
EMBO MOLECULAR MEDICINE
(2021)
Review
Medical Laboratory Technology
Shun Zhang, Lu Li, Jie Wang, Tingting Zhang, Ting Ye, Shuai Wang, Dongming Xing, Wujun Chen
Summary: lncRNAs, as a unique group of RNA transcripts longer than 200 nucleotides, regulate the roles of ABCA1 and ABCG1 in cholesterol efflux, influencing the development of atherosclerosis.
CLINICA CHIMICA ACTA
(2021)
Article
Cell Biology
Y. Li, X. -W. Tang, J. -Y. Wu, Y. -N. Huang, C. Liao
Article
Obstetrics & Gynecology
Can Liao, Jin Han, Daljit Sahota, Dong-zhi Li, Qian Sun, Lin Lin, Jian-ying Zhou, Xin Yang, Min Pan, Yi-ning Huang
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2010)
Article
Multidisciplinary Sciences
Yining Huang, Aftab Amin, Yan Qin, Ziyi Wang, Huadong Jiang, Lu Liang, Linjing Shi, Chun Liang
Article
Cell Biology
Rentian Wu, Aftab Amin, Ziyi Wang, Yining Huang, Marco Man-Hei Cheung, Zhiling Yu, Wei Yang, Chun Liang
Article
Obstetrics & Gynecology
Jian Ou, Meng-Xia Ni, Hong Li, Yining Huang, Qing-Xia Meng, Qian Zhang, Jie Ding, Qin-Yan Zou, Ai-Yan Zheng, Yan Zhang
Summary: This study demonstrates that mtDNA analysis has the ability to identify mosaic embryos with high developmental potential and can be a valuable supplementary index for the selection of mosaic embryos for transfer. Further research will enhance our understanding of the relationships between metabolic activity and mosaicism.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Biophysics
C. Liao, J. Y. Wu, Z. P. Xu, Y. Li, X. Yang, J. S. Chen, X. W. Tang, S. L. Gu, Y. N. Huang, P. H. Tang, K. S. Tsang
BONE MARROW TRANSPLANTATION
(2007)
Letter
Genetics & Heredity
Can Liao, Yining Huang, Dongzhi Li, Shuben Song, Cuixing Yi, Jianying Zhou
PRENATAL DIAGNOSIS
(2006)
Article
Cell & Tissue Engineering
J. Y. Wu, C. Liao, Z. P. Xu, J. S. Chen, S. L. Gu, Y. N. Huang, Y. Li, X. W. Tang, X. Yang, P. H. Tang, K. S. Tsang
Article
Obstetrics & Gynecology
Dongzhi Li, Can Liao, Han Li, Xingmei Xie, Yining Huang, Huizhu Zhong, Jiaxue Wei
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2006)
Article
Biochemistry & Molecular Biology
Dongzhi Li, Can Liao, Jian Li, Yining Huang, Xingmei Xie, Jiaxue Wei, Shaoqing Wu
Article
Hematology
Dongzhi Li, Can Liao, Jian Li, Xingmei Xie, Yining Huang, Huizhu Zhong
Article
Biochemistry & Molecular Biology
Can Liao, Qiong Feng, Jian Li, Yining Huang, Dongzhi Li
Article
Biochemistry & Molecular Biology
Can Liao, Qiuming Li, Jiaxue Wei, Qiong Feng, Jian Li, Yining Huang, Dongzhi Li
Letter
Genetics & Heredity
C Liao, DZ Li, JX Wei, XW Tang, Y Li, YN Huang
PRENATAL DIAGNOSIS
(2006)