Article
Biochemistry & Molecular Biology
Xueya Zhang, Shuang Liang, Qingnan Wu, Trevor C. Charles, Rui He, Jiakai Wu, Yuhui Zhao, Zhiyi Zhao, Hezhong Wang
Summary: This study investigated the mode of action of nanochitin whisker (NC) against Fusarium pseudograminearum (Fpg), an important pathogenic fungus causing wheat crown rot disease. The results showed that NC significantly reduced hyphal growth and spore germination rate of Fpg. It exerted its effects by disrupting cell wall structure, altering membrane integrity, decreasing enzyme activity related to energy-supply, and reducing mycotoxin production.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Microbiology
Xueqin Han, Qingyi Li, Xuenan Li, Xiang Lv, Li Zhang, Shenshen Zou, Jinfeng Yu, Hansong Dong, Lei Chen, Yuancun Liang
Summary: This study reveals that the deletion of Fgporin in Fusarium graminearum leads to defects in hyphal growth, conidiation, and perithecia development, as well as reduced virulence and impaired autophagy.
Article
Multidisciplinary Sciences
Yunqing Jian, Xia Chen, Temoor Ahmed, Qinghua Shang, Shuai Zhang, Zhonghua Ma, Yanni Yin
Summary: Fusarium graminearum is a destructive fungal pathogen causing Fusarium head blight (FHB) disease in cereal crops, leading to yield loss and mycotoxin contamination. Silver nanoparticles (AgNPs) show effective antifungal activity against fungicide-resistant and fungicide-sensitive F. graminearum strains, while inducing ROS generation, DON biosynthesis gene expression, and mycotoxin production. AgNPs have the potential to manage FHB in combination with DON-reducing fungicides.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Li Ma, Meng Yu, Yingjian Ma, Linying Gao, Shouhe Pan, Xuefeng Li, Xuemin Wu, Yong Xu, Sen Pang, Ping Wang
Summary: Nano-formulations of fungicides have significant biocontrol activities against fungal pathogens, as demonstrated by their rapid efficacy, internalization into fungal mycelia, and damage to cell membrane permeability. The advantages of nano-formulations in agriculture are highlighted.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Lin Tang, Haowen Chi, Weidong Li, Li Zhang, Liyuan Zhang, Lei Chen, Shenshen Zou, Huixiang Liu, Yuancun Liang, Jinfeng Yu, Hansong Dong
Summary: Our study characterized two yeast Psd orthologues, FgPsd1 and FgPsd2, in Fusarium graminearum, with FgPsd1 localized in mitochondria and FgPsd2 in Golgi. Deletion of FgPsd2 resulted in impaired mycelial growth, reproduction, virulence, lipid droplet formation, and autophagy in F. graminearum. The findings suggest that FgPsd2 plays a crucial role in multiple cellular processes in this fungus.
FUNGAL GENETICS AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Fanlong Wang, Xianbi Li, Yujie Li, Jing Han, Yang Chen, Jianyan Zeng, Mei Su, Jingxin Zhuo, Hui Ren, Haoru Liu, Lei Hou, Yanhua Fan, Xingying Yan, Shuiqing Song, Juan Zhao, Dan Jin, Mi Zhang, Yan Pei
Summary: The Arabidopsis P4-ATPases AtALA1 and AtALA7 are found to detoxify mycotoxins by promoting vesicle transport, leading to their sequestration and degradation in vacuoles. Overexpression of AtALA1 and AtALA7 enhances plant resistance to Fusarium graminearum and Verticillium dahliae, while reducing the concentration of harmful mycotoxins in Arabidopsis siliques and maize seeds. This vesicle-mediated cell detoxification process offers a strategy to boost plant resistance against toxin-associated diseases and lower mycotoxin contamination in food and feed.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Jing Zhang, Jing Chen, Lifang Hu, Ruimin Jia, Qing Ma, Jiangjiang Tang, Yang Wang
Summary: This research identifies a promising alternative to chemical pesticides, the Streptomyces pratensis S10, which effectively controls wheat scab by inhibiting F. graminearum growth. S10 can colonize in wheat roots, reduce toxin content, and shows potential for biological control applications.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Food Science & Technology
Han Yan, Xiangyi Meng, Xianfeng Lin, Nuo Duan, Zhouping Wang, Shijia Wu
Summary: Fusarium graminearum is a pathogen that infects grain crops and poses a threat to both agricultural production and public health. Ferulic acid, which is commonly extracted from traditional Chinese medicines, has shown potential as a fungicide due to its antibacterial, antioxidant, and anti-inflammatory properties. In this study, the inhibitory activity of ferulic acid against F. graminearum was evaluated, and its mechanism of action was investigated. The results showed that ferulic acid damages the cell membrane of F. graminearum, leading to cell leakage and impaired cell integrity. Additionally, ferulic acid inhibits ergosterol synthesis, confirming that its target site is the cell membrane.
Article
Biochemistry & Molecular Biology
Yanping Yuan, Meiru Zhang, Jingjing Li, Chengdong Yang, Yakubu Saddeeq Abubakar, Xin Chen, Wenhui Zheng, Zonghua Wang, Huawei Zheng, Jie Zhou
Summary: This study reveals that FgRab1 plays important roles in vegetative growth, conidiogenesis, pathogenicity, autophagy, vesicle fusion, and trafficking in the devastating wheat pathogen Fusarium graminearum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Bimal Paudel, Connor Pedersen, Yang Yen, Shin-Yi Lee Marzano
Summary: Research identified that DON toxin production by F. graminearum during infection of small grain crops is a major contributor to economic losses. A novel strain of Fusarium graminearum virus 1 (FgV1-SD4) was discovered, which showed reduced virulence of F. graminearum against wheat and decreased DON accumulation in infected seeds. This mycovirus strain and specific genetic components of FgV1-SD4 could be further optimized as a biocontrol agent to reduce Fusarium head blight and DON accumulation in small grain crops.
Article
Microbiology
Jisuk Yu, Kook-Hyung Kim
Summary: Through gene deletion experiments, it was found that some transcription factors are related to viral replication and symptom induction during FgV1 infection of F. graminearum fungi, leading to different mycelial growth phenotypes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Gudam Kwon, Jisuk Yu, Kook-Hyung Kim
Summary: Infection of Fusarium graminearum virus 2 (FgV2) leads to phenotypic changes and alteration of the transcriptome, including gene transcripts of various transcription factors (TFs) in F. graminearum. By transferring FgV2 to a F. graminearum TF gene deletion mutant library, host TFs related to FgV2 infection were identified. FgV2-infected TF mutants were classified into three groups based on colony growth, and potential TFs involved in FgV2 accumulation, generation of defective interfering RNAs, and transcriptional regulation were identified.
Article
Microbiology
Izabela Podgorska-Kryszczuk, Ewa Solarska, Monika Kordowska-Wiater
Summary: Yeasts isolated from organic cereals showed strong inhibitory activity against Fusarium pathogens, with mechanisms including nutrient competition and inhibition of spore germination.
Article
Plant Sciences
Skaidre Suproniene, Grazina Kadziene, Arman Shamshitov, Agne Versuliene, Donatas Sneideris, Algirdas Ivanauskas, Renata Zvirdauskiene
Summary: The study aimed to assess the influence of different soil tillage systems on the suppression of Fusarium graminearum, a harmful pathogen, by soil fungistasis. Soil samples were collected from a long-term soil tillage experiment and analyzed using real-time qPCR and in vitro assay. The results showed a negative correlation between F. graminearum DNA content and soil fungistasis. The presence of F. graminearum was suppressed by soil fungistasis, but the role of tillage was influenced by other factors.
Article
Food Science & Technology
Jian Guo, Jiaoyu Wang, Hui Xie, Junlong Jiang, Chunyuan Li, Wanting Li, Ling Li, Xingquan Liu, Fucheng Lin
Summary: The usage of fungicides is potentially harmful to the environment and organisms, prompting researchers to explore alternatives such as Plasma-activated water (PAW) for inactivating phytopathogens. The study found that PAW significantly inhibited spore activity and reduced symptoms caused by Fusarium graminearum, inducing changes in cell wall sculpturing, membrane permeability, and mitochondrial function. This suggests the potential of PAW as a fungicidal agent or supplement to traditional fungicides.
Article
Cardiac & Cardiovascular Systems
Yang Liu, Yabin Zhang, Hongyu Chen, Jiahui Zhao, Qiang Ma, Guang Yang, Xiaohua Wang, Zhen Wu, Jiebin Hou, Qingli Cheng, Qiangguo Ao
Summary: This study investigated the efficacy of adding tolvaptan (TLV) in improving the prognosis of elderly patients with acute heart failure (AHF) and oliguria. The results showed that adding TLV significantly increased urine output, reduced NT-proBNP levels, alleviated the progression of AHF, and may reduce the risk of all-cause mortality at 7 and 90-day in elderly patients with AHF with oliguria.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Junfeng Wang, Xiaohua Wang, Bin Sun, Liang Yuan, Ke Zhang, Bin Yang
Summary: The variability of patellar height was reduced with the use of 3D printed patient-specific instrumentation in total knee arthroplasty (TKA). However, even with 3D-printed PSI, there were still significant reductions in patellar height and other radiographic parameters after TKA, which could lead to more patellofemoral complications.
FRONTIERS IN SURGERY
(2023)
Article
Psychology, Multidisciplinary
Qing Yang, Kunqiang Zhao, Lanjuan Cao, Xiaohua Wang, Qizhe Guo, Xingxing Liu
Summary: The combination of technology and finance has a significant impact on regional social and economic development. Strategic emerging industries, as the convergence of technological innovation and financial support, are of great significance for industrial structure adjustment and improvement of industrial quality. However, the geographical distribution of emerging strategic industries in China is uneven. Thus, this study investigates the input-output efficiency of science and technology finance integration and examines the path of integrated development of science and technology innovation and financial support. The findings reveal the large demand for financial support and obvious regional differences in the development of strategic emerging industries, with the government playing a strong guiding role. Measures and suggestions for the development of strategic emerging industries are proposed accordingly.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jing-yu Weng, Xin-xing Chen, Xiao-hua Wang, Hui-er Ye, Yan-ping Wu, Wan-yang Sun, Lei Liang, Wen-jun Duan, Hiroshi Kurihara, Feng Huang, Xin-xin Sun, Shu-hua Ou-Yang, Rong-rong He, Yi-fang Li
Summary: Psychological stress increases susceptibility to HSV-1 infection, and the underlying molecular mechanisms are unknown. This study explored the antiviral effect of rosmarinic acid (RA) and demonstrated that RA could decrease stress-augmented mortality and reduce symptoms in HSV-1-infected mice. In vitro, RA increased cell viability and inhibited stress-induced elevation of viral proteins and genes. The study revealed the critical role of lipid peroxidation in stress-induced HSV-1 susceptibility and suggested the potential of RA as an effective intervention in anti-HSV-1 therapy.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Chemistry, Applied
Xiaohua Wang, Ying Liang, Qi Wang, Xinlan Wang, Hanyan Li, Jinshui Wang
Summary: In this study, the correlations between dough rheology and gluten aggregation were investigated by analyzing the rheological properties of low-sodium salt dough and the molecular properties of dough gluten. The results showed that low-sodium salt improved the hardness, extensibility, and compression resistance of the dough, and induced the formation of larger protein clusters. The analysis also revealed that low-sodium salt increased the content of certain glutenin subunits and reduced the content of certain gliadin fractions, resulting in the aggregation of gluten. This study provides new insights and a more comprehensive theoretical basis for sodium reduction.
FOOD HYDROCOLLOIDS
(2023)
Article
Engineering, Electrical & Electronic
Xi Ran, Xiao-Hua Wang, Teng-Fei Wei, Shi-Wei Qu, Bing-Zhong Wang
Summary: In this article, an inverse design for a dielectric-type superstrate of antenna is proposed using the inverse scattering method to achieve arbitrary shaped-beam radiation pattern. The permittivity distribution of the superstrate is reconstructed based on the known desired radiation patterns, and the scattering fields can be assumed in the far-zone. The reconstructed superstrate parameters are validated through 2-D and 3-D simulations, showing good agreement and efficient performance compared to traditional forward design methods.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Immunology
Hui Guan, Ming Zhong, Kongyang Ma, Chun Tang, Xiaohua Wang, Muzi Ouyang, Rencai Qin, Jiasi Chen, Enyi Zhu, Ting Zhu, Yongping Lu, Yu Liu, Chengzi Tian, Zhihua Zheng
Summary: This study comprehensively investigated the roles and mechanisms of HMGB1 in different tumors. HMGB1 was found to be differentially expressed in many tumors and normal tissues, and was closely related to tumor burden, drug resistance, and various pathways of tumors. HMGB1 may serve as a novel biomarker for predicting tumor prognosis and efficacy of immune checkpoint inhibitors, and a potential target for anti-tumor therapy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Dou Ye, Suqing Qu, Yinxiang Yang, Zhaoyan Wang, Qian Wang, Weipeng Liu, Fan Zhang, Qian Guan, Xiaohua Wang, Jing Zang, Xin Li, Hengtao Liu, Ruiqin Yao, Zhichun Feng, Zuo Luan
Summary: Immunosuppressants are not suitable for premature infants, but desensitization can induce immune tolerance. In this study, Wistar rat fetuses were injected with hOPCs-1 and returned to the mother. After desensitization, brain and muscle transplantation was performed with hOPCs-1, hNSCs-1, and hOPCs-2. The desensitized group showed higher levels of hOPCs-1 and hNSCs-1 compared to the control group, while hOPCs-2 were rejected. There were significant differences in Treg, CD4CD28, CD8CD28, and CD45RC between the desensitization and control group. Inflammatory cells were lower in the desensitized group with hOPCs-1 and hNSCs-1. hOPCs-1 could differentiate into myelin in the desensitized group. Wistar rats with desensitization developed immune tolerance.
Article
Cardiac & Cardiovascular Systems
Jiebin Hou, Xin Zhang, Zhen Wu, Yang Liu, Yabin Zhang, Jiahui Zhao, Xiaohua Wang, Hongyu Chen, Guang Yang, Qiang Ma, Qingli Cheng, Qiangguo Ao
Summary: Elderly patients with chronic heart failure (CHF) have a higher incidence of acute kidney injury (AKI), which can lead to poor prognosis. The relationship between kidney dysfunction and levels of N-terminal pro-brain natriuretic peptides (NT-proBNP) in elderly CHF patients has been analyzed in a retrospective cohort study. The results suggest that a decreased change in NT-proBNP during AKI can reduce the risk of more severe AKI and improve survival outcomes. However, an excessive decrease in NT-proBNP is a risk factor for non-recovery of renal function following AKI, especially in elderly survivors with low baseline NT-proBNP levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jiasi Chen, Keping Wu, Yan Lei, Mingcheng Huang, Lokyu Cheng, Hui Guan, Jiawen Lin, Ming Zhong, Xiaohua Wang, Zhihua Zheng
Summary: The role of FABP4 in regulating ferroptosis in diabetic kidney disease was explored. The expression of FABP4 was found to be increased in kidney biopsies of DKD patients. Inhibition of FABP4 in HG-HK2 cells altered the redox state, suppressed the production of reactive oxygen species and iron, and reversed ferroptosis-associated mitochondrial damage.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Orthopedics
Xiaohua Wang, Lin Xie, Shuo Yang
Summary: This research investigates the correlation between the weight-adjusted-waist Index (WWI) and the incidence of Rheumatoid Arthritis (RA) and Osteoarthritis (OA). The findings reveal a linear positive correlation between WWI and OA prevalence, and a complex non-linear relationship with RA prevalence.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Chemistry, Applied
Xiaohua Wang, Yangyang Chen, Jingjing Zhang, Zewen Wang, Kaijie Qi, Hongxiang Li, Ruiping Tian, Xiao Wu, Xin Qiao, Shaoling Zhang, Hao Yin
Summary: The aroma composition of 202 pear cultivars' mature fruits was analyzed using GC-MS. A total of 221 major volatile components were detected, with aldehydes, esters, and alcohols being the dominant aroma components. Variations in aroma composition and content were observed among different pear varieties, and geographical flavor characteristics were also identified. These findings provide important insights for understanding aroma variations in pear varieties and promoting pear breeding programs.
Article
Environmental Sciences
Xiaohua Wang, Yimeng Wang, Nannan Liu
Summary: The economic differentiation between the north and the south of China is aggravating, and environmental regulation plays a significant role in widening the economic gap. Based on panel data of 285 cities in China from 2004 to 2019, the study finds that environmental regulation has a significant positive impact on narrowing the economic gap between the North and the South, but its effect shows a non-linear relationship.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Medicine, Research & Experimental
Xiaohua Wang, Xiang Shi, Dahua Sun, Meiping Wan
Summary: This case report analyzed the clinical symptoms, fine-needle aspiration cytology, histopathological and immunohistochemical results of a patient with angiolymphoid hyperplasia with eosinophilia (ALHE), and summarized the clinicopathological diagnostic features of the disease. As far as we know, this is the first comprehensive report on the cytological, histopathological and immunophenotypic characteristics of ALHE, which could contribute to a better understanding of this rare proliferative tumor for clinicians.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)