Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

(2022) Elizabeth R. Murray et al.   Cell Reports

Cancer‐associated fibroblasts in pancreatic cancer: new subtypes, new markers, new targets

(2022) Shinelle Menezes et al.   JOURNAL OF PATHOLOGY

Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer

(2022) R. C. Coombes et al.   Nature Communications

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

(2021) Yang Chen et al.   CANCER CELL

Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption

(2021) Sophie D. Adams et al.   CURRENT BIOLOGY

Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts

(2021) Mireia Berdiel-Acer et al.   ONCOGENE

Nuclear FGFR1 regulates gene transcription and promotes antiestrogen resistance in ER+ breast cancer

(2021) Alberto Servetto et al.   CLINICAL CANCER RESEARCH

Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer

(2021) Edward P. Carter et al.   Cells

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

(2020) Sohinee Bhattacharyya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

(2020) Won Jin Ho et al.   Nature Reviews Clinical Oncology

Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

(2020) Zeda Zhang et al.   CANCER CELL

Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer

(2020) Hemant M. Kocher et al.   Nature Communications

NRG1 gene fusions are recurrent, clinically actionable gene rearrangements in KRAS wild-type pancreatic ductal adenocarcinoma

(2019) Martin R Jones et al.   CLINICAL CANCER RESEARCH

Clinical Trials Targeting the Stroma in Pancreatic Cancer: A Systematic Review and Meta-Analysis

(2019) van Mackelenbergh et al.   Cancers

HALO-109–301: a Phase III trial of PEGPH20 (with gemcitabine and nab-paclitaxel) in hyaluronic acid-high stage IV pancreatic cancer

(2018) Gary J Doherty et al.   Future Oncology

Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options

(2018) Derya Kabacaoglu et al.   Frontiers in Immunology

Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

(2018) Cindy Neuzillet et al.   JOURNAL OF PATHOLOGY

A comprehensive review of heregulins, HER3, and HER4 as potential therapeutic targets in cancer

(2017) Jose Mauricio Mota et al.   Oncotarget

Evidence-Based Theory for Integrated Genome Regulation of Ontogeny-An Unprecedented Role of Nuclear FGFR1 Signaling

(2016) Michal K. Stachowiak et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma

(2016) Elisabete F Carapuça et al.   JOURNAL OF PATHOLOGY

Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

(2015) Edward P. Carter et al.   TRENDS IN CELL BIOLOGY

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion

(2014) S. J. Coleman et al.   EMBO Molecular Medicine

Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes

(2013) Raghu Kadaba et al.   JOURNAL OF PATHOLOGY

FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior

(2012) Athina-Myrto Chioni et al.   JOURNAL OF CELL BIOLOGY

Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression

(2011) Fieke E.M. Froeling et al.   GASTROENTEROLOGY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE